Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan

Ai Miyashiro; Naoko Matsui; Yoshimitsu Shimatani; Hiroyuki Nodera; Yuishin Izumi; Satoshi Kuwabara; Tomihiro Imai; Masayuki Baba; Tetsuo Komori; Masahiro Sonoo; Takahiro Mezaki; Jun Kawamata; Takefumi Hitomi; Nobuo Kohara; Kimiyoshi Arimura; Shuji Hashimoto; Kokichi Arisawa; Susumu Kusunoki; Ryuji Kaji

doi:10.1002/mus.23930

Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan

Ai Miyashiro, Naoko Matsui, Yoshimitsu Shimatani, Hiroyuki Nodera, Yuishin Izumi, Satoshi Kuwabara, Tomihiro Imai, Masayuki Baba, Tetsuo Komori, Masahiro Sonoo, Takahiro Mezaki, Jun Kawamata, Takefumi Hitomi, Nobuo Kohara, Kimiyoshi Arimura, Shuji Hashimoto, Kokichi Arisawa, Susumu Kusunoki, Ryuji Kaji

Hygiene

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Introduction: Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. Methods: In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. Results: The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. Conclusions: The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers.

Original language	English
Pages (from-to)	357-361
Number of pages	5
Journal	Muscle and Nerve
Volume	49
Issue number	3
DOIs	https://doi.org/10.1002/mus.23930
Publication status	Published - 03-2014

All Science Journal Classification (ASJC) codes

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/mus.23930

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Miyashiro, A., Matsui, N., Shimatani, Y., Nodera, H., Izumi, Y., Kuwabara, S., Imai, T., Baba, M., Komori, T., Sonoo, M., Mezaki, T., Kawamata, J., Hitomi, T., Kohara, N., Arimura, K., Hashimoto, S., Arisawa, K., Kusunoki, S., & Kaji, R. (2014). Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan. Muscle and Nerve, 49(3), 357-361. https://doi.org/10.1002/mus.23930

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title = "Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan",

abstract = "Introduction: Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. Methods: In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. Results: The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. Conclusions: The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers.",

author = "Ai Miyashiro and Naoko Matsui and Yoshimitsu Shimatani and Hiroyuki Nodera and Yuishin Izumi and Satoshi Kuwabara and Tomihiro Imai and Masayuki Baba and Tetsuo Komori and Masahiro Sonoo and Takahiro Mezaki and Jun Kawamata and Takefumi Hitomi and Nobuo Kohara and Kimiyoshi Arimura and Shuji Hashimoto and Kokichi Arisawa and Susumu Kusunoki and Ryuji Kaji",

year = "2014",

month = mar,

doi = "10.1002/mus.23930",

language = "English",

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Miyashiro, A, Matsui, N, Shimatani, Y, Nodera, H, Izumi, Y, Kuwabara, S, Imai, T, Baba, M, Komori, T, Sonoo, M, Mezaki, T, Kawamata, J, Hitomi, T, Kohara, N, Arimura, K, Hashimoto, S, Arisawa, K, Kusunoki, S & Kaji, R 2014, 'Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan', Muscle and Nerve, vol. 49, no. 3, pp. 357-361. https://doi.org/10.1002/mus.23930

TY - JOUR

T1 - Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan

AU - Miyashiro, Ai

AU - Matsui, Naoko

AU - Shimatani, Yoshimitsu

AU - Nodera, Hiroyuki

AU - Izumi, Yuishin

AU - Kuwabara, Satoshi

AU - Imai, Tomihiro

AU - Baba, Masayuki

AU - Komori, Tetsuo

AU - Sonoo, Masahiro

AU - Mezaki, Takahiro

AU - Kawamata, Jun

AU - Hitomi, Takefumi

AU - Kohara, Nobuo

AU - Arimura, Kimiyoshi

AU - Hashimoto, Shuji

AU - Arisawa, Kokichi

AU - Kusunoki, Susumu

AU - Kaji, Ryuji

PY - 2014/3

Y1 - 2014/3

N2 - Introduction: Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. Methods: In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. Results: The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. Conclusions: The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers.

AB - Introduction: Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. Methods: In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. Results: The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. Conclusions: The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers.

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Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan

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