Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan

Ai Miyashiro, Naoko Matsui, Yoshimitsu Shimatani, Hiroyuki Nodera, Yuishin Izumi, Satoshi Kuwabara, Tomihiro Imai, Masayuki Baba, Tetsuo Komori, Masahiro Sonoo, Takahiro Mezaki, Jun Kawamata, Takefumi Hitomi, Nobuo Kohara, Kimiyoshi Arimura, Shuji Hashimoto, Kokichi Arisawa, Susumu Kusunoki, Ryuji Kaji

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Introduction: Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. Methods: In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. Results: The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. Conclusions: The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalMuscle and Nerve
Volume49
Issue number3
DOIs
Publication statusPublished - 01-01-2014

Fingerprint

Japan
Amyotrophic Lateral Sclerosis
Surveys and Questionnaires
Intravenous Immunoglobulins
Retrospective Studies
Population

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Miyashiro, A., Matsui, N., Shimatani, Y., Nodera, H., Izumi, Y., Kuwabara, S., ... Kaji, R. (2014). Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan. Muscle and Nerve, 49(3), 357-361. https://doi.org/10.1002/mus.23930
Miyashiro, Ai ; Matsui, Naoko ; Shimatani, Yoshimitsu ; Nodera, Hiroyuki ; Izumi, Yuishin ; Kuwabara, Satoshi ; Imai, Tomihiro ; Baba, Masayuki ; Komori, Tetsuo ; Sonoo, Masahiro ; Mezaki, Takahiro ; Kawamata, Jun ; Hitomi, Takefumi ; Kohara, Nobuo ; Arimura, Kimiyoshi ; Hashimoto, Shuji ; Arisawa, Kokichi ; Kusunoki, Susumu ; Kaji, Ryuji. / Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan. In: Muscle and Nerve. 2014 ; Vol. 49, No. 3. pp. 357-361.
@article{cfd0664e44a3466a892920c92432b1aa,
title = "Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan",
abstract = "Introduction: Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. Methods: In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. Results: The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. Conclusions: The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers.",
author = "Ai Miyashiro and Naoko Matsui and Yoshimitsu Shimatani and Hiroyuki Nodera and Yuishin Izumi and Satoshi Kuwabara and Tomihiro Imai and Masayuki Baba and Tetsuo Komori and Masahiro Sonoo and Takahiro Mezaki and Jun Kawamata and Takefumi Hitomi and Nobuo Kohara and Kimiyoshi Arimura and Shuji Hashimoto and Kokichi Arisawa and Susumu Kusunoki and Ryuji Kaji",
year = "2014",
month = "1",
day = "1",
doi = "10.1002/mus.23930",
language = "English",
volume = "49",
pages = "357--361",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

Miyashiro, A, Matsui, N, Shimatani, Y, Nodera, H, Izumi, Y, Kuwabara, S, Imai, T, Baba, M, Komori, T, Sonoo, M, Mezaki, T, Kawamata, J, Hitomi, T, Kohara, N, Arimura, K, Hashimoto, S, Arisawa, K, Kusunoki, S & Kaji, R 2014, 'Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan', Muscle and Nerve, vol. 49, no. 3, pp. 357-361. https://doi.org/10.1002/mus.23930

Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan. / Miyashiro, Ai; Matsui, Naoko; Shimatani, Yoshimitsu; Nodera, Hiroyuki; Izumi, Yuishin; Kuwabara, Satoshi; Imai, Tomihiro; Baba, Masayuki; Komori, Tetsuo; Sonoo, Masahiro; Mezaki, Takahiro; Kawamata, Jun; Hitomi, Takefumi; Kohara, Nobuo; Arimura, Kimiyoshi; Hashimoto, Shuji; Arisawa, Kokichi; Kusunoki, Susumu; Kaji, Ryuji.

In: Muscle and Nerve, Vol. 49, No. 3, 01.01.2014, p. 357-361.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan

AU - Miyashiro, Ai

AU - Matsui, Naoko

AU - Shimatani, Yoshimitsu

AU - Nodera, Hiroyuki

AU - Izumi, Yuishin

AU - Kuwabara, Satoshi

AU - Imai, Tomihiro

AU - Baba, Masayuki

AU - Komori, Tetsuo

AU - Sonoo, Masahiro

AU - Mezaki, Takahiro

AU - Kawamata, Jun

AU - Hitomi, Takefumi

AU - Kohara, Nobuo

AU - Arimura, Kimiyoshi

AU - Hashimoto, Shuji

AU - Arisawa, Kokichi

AU - Kusunoki, Susumu

AU - Kaji, Ryuji

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Introduction: Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. Methods: In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. Results: The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. Conclusions: The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers.

AB - Introduction: Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. Methods: In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. Results: The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. Conclusions: The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers.

UR - http://www.scopus.com/inward/record.url?scp=84893935930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893935930&partnerID=8YFLogxK

U2 - 10.1002/mus.23930

DO - 10.1002/mus.23930

M3 - Article

C2 - 24741683

AN - SCOPUS:84893935930

VL - 49

SP - 357

EP - 361

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 3

ER -

Miyashiro A, Matsui N, Shimatani Y, Nodera H, Izumi Y, Kuwabara S et al. Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan. Muscle and Nerve. 2014 Jan 1;49(3):357-361. https://doi.org/10.1002/mus.23930