Are there histopathologic characteristics particular to fulminant hepatic failure caused by human herpesvirus-6 infection? A case report and discussion

Kiyoshi Aita, Yi Jin, Hiroshi Irie, Ichiro Takahashi, Katsumi Kobori, Yutaka Nakasato, Hiroko Kodama, Yukishige Yanagawa, Tetsushi Yoshikawa, Junji Shiga

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22 Citations (Scopus)


An 8-month-old boy was admitted to a neighboring hospital for severe liver dysfunction and drowsiness 4 days after a diagnosis of exanthem subitum. A diagnosis of fulminant hepatic failure was made, and liver biopsy was performed during the acute stage. The presence of human herpesvirus-6 variant B (HHV-6B) DNA was shown in liver tissue by polymerase chain reaction (PCR) and in the endothelium of the portal vein by in situ hybridization (ISH). Histologic examination showed microvesicular steatosis resembling that of Reye's syndrome, even though aspirin had not been prescribed. We considered HHV-6 to be the causative agent in this case and report what is perhaps the first precise histologic description of fulminant hepatric failure caused by HHV-6.

Original languageEnglish
Pages (from-to)887-889
Number of pages3
JournalHuman Pathology
Issue number8
Publication statusPublished - 01-01-2001


All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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