Arterial stiffness and QT interval prolongation in a general population

The Hisayama study

Daisuke Maebuchi, Hisatomi Arima, Toshiharu Ninomiya, Koji Yonemoto, Michiaki Kubo, Yasufumi Doi, Yumihiro Tanizaki, Kiyoshi Matsumura, Mitsuo Iida, Yutaka Kiyohara

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Few population studies have addressed the association of QT interval prolongation with clinical or subclinical arterial disease. The primary objective here was to examine the relationship between the pulse wave velocity (PWV) and the heart rate-corrected QT interval duration (QTc). This is a cross-sectional study, based on a survey of a general population of Japanese. We examined 2,666 community-dwelling individuals without history of cardiovascular disease, aged 40 or over. The PWV was measured between the brachial and ankle regions (baPWV). QTc was estimated using Bazett's equation. The age-adjusted mean values of QTc increased progressively with rising baPWV levels for either sex: for men, 397, 401, 403, and 406 ms for quartile groups defined by baPWV values of less than 1,369, 1,370 to 1,560, 1,561 to 1,840, and 1,841 or greater cm/s, respectively (p<0.0001 for trend); for women, 406, 410, 414, and 417 ms for quartile groups defined by baPWV of less than 1,269, 1,270 to 1,493, 1,494 to 1,821, and 1,822 or greater cm/s, respectively (p<0.0001 for trend). When male and female subjects were combined, this positive relationship between baPWV and QTc remained significant, even after controlling for age, sex, hypertension, ECG abnormalities, dyslipidemia, diabetes, obesity, serum calcium and potassium, alcohol intake, and smoking habits (p<0.0001 for trend). In conclusion, baPWV is independently associated with QT interval prolongation.

Original languageEnglish
Pages (from-to)1339-1345
Number of pages7
JournalHypertension Research
Volume31
Issue number7
DOIs
Publication statusPublished - 11-11-2008
Externally publishedYes

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Pulse Wave Analysis
Vascular Stiffness
Independent Living
Dyslipidemias
Ankle
Population
Habits
Potassium
Electrocardiography
Arm
Cardiovascular Diseases
Obesity
Cross-Sectional Studies
Heart Rate
Smoking
Alcohols
Hypertension
Calcium
Serum
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Maebuchi, D., Arima, H., Ninomiya, T., Yonemoto, K., Kubo, M., Doi, Y., ... Kiyohara, Y. (2008). Arterial stiffness and QT interval prolongation in a general population: The Hisayama study. Hypertension Research, 31(7), 1339-1345. https://doi.org/10.1291/hypres.31.1339
Maebuchi, Daisuke ; Arima, Hisatomi ; Ninomiya, Toshiharu ; Yonemoto, Koji ; Kubo, Michiaki ; Doi, Yasufumi ; Tanizaki, Yumihiro ; Matsumura, Kiyoshi ; Iida, Mitsuo ; Kiyohara, Yutaka. / Arterial stiffness and QT interval prolongation in a general population : The Hisayama study. In: Hypertension Research. 2008 ; Vol. 31, No. 7. pp. 1339-1345.
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Maebuchi, D, Arima, H, Ninomiya, T, Yonemoto, K, Kubo, M, Doi, Y, Tanizaki, Y, Matsumura, K, Iida, M & Kiyohara, Y 2008, 'Arterial stiffness and QT interval prolongation in a general population: The Hisayama study', Hypertension Research, vol. 31, no. 7, pp. 1339-1345. https://doi.org/10.1291/hypres.31.1339

Arterial stiffness and QT interval prolongation in a general population : The Hisayama study. / Maebuchi, Daisuke; Arima, Hisatomi; Ninomiya, Toshiharu; Yonemoto, Koji; Kubo, Michiaki; Doi, Yasufumi; Tanizaki, Yumihiro; Matsumura, Kiyoshi; Iida, Mitsuo; Kiyohara, Yutaka.

In: Hypertension Research, Vol. 31, No. 7, 11.11.2008, p. 1339-1345.

Research output: Contribution to journalArticle

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T1 - Arterial stiffness and QT interval prolongation in a general population

T2 - The Hisayama study

AU - Maebuchi, Daisuke

AU - Arima, Hisatomi

AU - Ninomiya, Toshiharu

AU - Yonemoto, Koji

AU - Kubo, Michiaki

AU - Doi, Yasufumi

AU - Tanizaki, Yumihiro

AU - Matsumura, Kiyoshi

AU - Iida, Mitsuo

AU - Kiyohara, Yutaka

PY - 2008/11/11

Y1 - 2008/11/11

N2 - Few population studies have addressed the association of QT interval prolongation with clinical or subclinical arterial disease. The primary objective here was to examine the relationship between the pulse wave velocity (PWV) and the heart rate-corrected QT interval duration (QTc). This is a cross-sectional study, based on a survey of a general population of Japanese. We examined 2,666 community-dwelling individuals without history of cardiovascular disease, aged 40 or over. The PWV was measured between the brachial and ankle regions (baPWV). QTc was estimated using Bazett's equation. The age-adjusted mean values of QTc increased progressively with rising baPWV levels for either sex: for men, 397, 401, 403, and 406 ms for quartile groups defined by baPWV values of less than 1,369, 1,370 to 1,560, 1,561 to 1,840, and 1,841 or greater cm/s, respectively (p<0.0001 for trend); for women, 406, 410, 414, and 417 ms for quartile groups defined by baPWV of less than 1,269, 1,270 to 1,493, 1,494 to 1,821, and 1,822 or greater cm/s, respectively (p<0.0001 for trend). When male and female subjects were combined, this positive relationship between baPWV and QTc remained significant, even after controlling for age, sex, hypertension, ECG abnormalities, dyslipidemia, diabetes, obesity, serum calcium and potassium, alcohol intake, and smoking habits (p<0.0001 for trend). In conclusion, baPWV is independently associated with QT interval prolongation.

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