Artificially produced meteorological changes aggravate pain in adjuvant-induced arthritic rats

Jun Sato, Morihiko Aoyama, Masahiro Yamazaki, Satoshi Okumura, Ken Takahashi, Megumi Funakubo, Kazue Mizumura

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


To examine the effects of change in meteorological parameters on pain-related behaviors in a simulated arthritic condition, rats with an injection of complete Freund's adjuvant into the tibio-tarsal joint were exposed to low barometric pressure (20 mmHg below the natural atmospheric pressure) and low ambient temperature (7°C lower than 22°C) in a climate-controlled room. When the arthritic rats were exposed to these environments, the already increased number of hindpaw withdrawals in response to noxious mechanical stimulation (hyperalgesia) was further increased, and a hindpaw withdrawal response to innocuous mechanical stimulation (allodynia) began to occur. Such exposures did not influence any of the pain-related behaviors of the control rats. These results show that lowering barometric pressure and ambient temperature within the range of natural environmental fluctuation intensify pain in arthritic rats.

Original languageEnglish
Pages (from-to)46-49
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 02-01-2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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