TY - JOUR
T1 - Artificially produced meteorological changes aggravate pain in adjuvant-induced arthritic rats
AU - Sato, Jun
AU - Aoyama, Morihiko
AU - Yamazaki, Masahiro
AU - Okumura, Satoshi
AU - Takahashi, Ken
AU - Funakubo, Megumi
AU - Mizumura, Kazue
PY - 2004/1/2
Y1 - 2004/1/2
N2 - To examine the effects of change in meteorological parameters on pain-related behaviors in a simulated arthritic condition, rats with an injection of complete Freund's adjuvant into the tibio-tarsal joint were exposed to low barometric pressure (20 mmHg below the natural atmospheric pressure) and low ambient temperature (7°C lower than 22°C) in a climate-controlled room. When the arthritic rats were exposed to these environments, the already increased number of hindpaw withdrawals in response to noxious mechanical stimulation (hyperalgesia) was further increased, and a hindpaw withdrawal response to innocuous mechanical stimulation (allodynia) began to occur. Such exposures did not influence any of the pain-related behaviors of the control rats. These results show that lowering barometric pressure and ambient temperature within the range of natural environmental fluctuation intensify pain in arthritic rats.
AB - To examine the effects of change in meteorological parameters on pain-related behaviors in a simulated arthritic condition, rats with an injection of complete Freund's adjuvant into the tibio-tarsal joint were exposed to low barometric pressure (20 mmHg below the natural atmospheric pressure) and low ambient temperature (7°C lower than 22°C) in a climate-controlled room. When the arthritic rats were exposed to these environments, the already increased number of hindpaw withdrawals in response to noxious mechanical stimulation (hyperalgesia) was further increased, and a hindpaw withdrawal response to innocuous mechanical stimulation (allodynia) began to occur. Such exposures did not influence any of the pain-related behaviors of the control rats. These results show that lowering barometric pressure and ambient temperature within the range of natural environmental fluctuation intensify pain in arthritic rats.
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U2 - 10.1016/j.neulet.2003.09.057
DO - 10.1016/j.neulet.2003.09.057
M3 - Article
C2 - 14698479
AN - SCOPUS:0346786363
SN - 0304-3940
VL - 354
SP - 46
EP - 49
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -