Ascidian mitochondrial tRNA(Met) possessing unique structural characteristics

Akiko Kondow, Shin Ichi Yokobori, Takuya Ueda, Kimitsuna Watanabe

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Methionine tRNA was purified from muscle mitochondria of the ascidian Halocynthia roretzi and its RNA sequence was determined. Analysis of the nucleotide sequence revealed that unlike most metazoan mitochondrial tRNAs(Met), which have a highly conserved cytidine (C) or C-derivative at the wobble position, the H. roretzi mitochondrial tRNA(Met) possesses 5- carboxymethylaminomethyluridine (cmnm5U) at the first position of the anticodon. This is the first report of a single mitochondrial tRNA(Met) species having uridine (U) or a U-derivative at the wobble position.

Original languageEnglish
Pages (from-to)531-539
Number of pages9
JournalNucleosides and Nucleotides
Issue number1-3
Publication statusPublished - 1998

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics


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