Aspects of immune dysfunction in end-stage renal disease

Sawako Kato, Michal Chmielewski, Hirokazu Honda, Roberto Pecoits-Filho, Seiichi Matsuo, Yukio Yuzawa, Anders Tranaeus, Peter Stenvinkel, Bengt Lindholm

Research output: Contribution to journalReview article

313 Citations (Scopus)

Abstract

End-stage renal disease (ESRD) is associated with significantly increased morbidity and mortality resulting from cardiovascular disease (CVD) and infections, accounting for 50% and 20%, respectively, of the total mortality in ESRD patients. It is possible that these two complications are linked to alterations in the immune system in ESRD, as uremia is associated with a state of immune dysfunction characterized by immunodepression that contributes to the high prevalence of infections among these patients, as well as by immunoactivation resulting in inflammation that may contribute to CVD. This review describes disorders of the innate and adaptive immune systems in ESRD, underlining the specific role of ESRD-associated disturbances of Toll-like receptors. Finally, based on the emerging links between the alterations of immune system, CVD, and infections in ESRD patients, it emphasizes the potential role of the immune dysfunction in ESRD as an underlying cause for the high mortality in this patient population and the need for more studies in this area.

Original languageEnglish
Pages (from-to)1526-1533
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Volume3
Issue number5
DOIs
Publication statusPublished - 01-09-2008
Externally publishedYes

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Chronic Kidney Failure
Cardiovascular Infections
Cardiovascular Diseases
Mortality
Immune System
Uremia
Toll-Like Receptors
Immune System Diseases
Immunosuppression
Inflammation
Morbidity
Infection
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

Cite this

Kato, S., Chmielewski, M., Honda, H., Pecoits-Filho, R., Matsuo, S., Yuzawa, Y., ... Lindholm, B. (2008). Aspects of immune dysfunction in end-stage renal disease. Clinical Journal of the American Society of Nephrology, 3(5), 1526-1533. https://doi.org/10.2215/CJN.00950208
Kato, Sawako ; Chmielewski, Michal ; Honda, Hirokazu ; Pecoits-Filho, Roberto ; Matsuo, Seiichi ; Yuzawa, Yukio ; Tranaeus, Anders ; Stenvinkel, Peter ; Lindholm, Bengt. / Aspects of immune dysfunction in end-stage renal disease. In: Clinical Journal of the American Society of Nephrology. 2008 ; Vol. 3, No. 5. pp. 1526-1533.
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Kato, S, Chmielewski, M, Honda, H, Pecoits-Filho, R, Matsuo, S, Yuzawa, Y, Tranaeus, A, Stenvinkel, P & Lindholm, B 2008, 'Aspects of immune dysfunction in end-stage renal disease', Clinical Journal of the American Society of Nephrology, vol. 3, no. 5, pp. 1526-1533. https://doi.org/10.2215/CJN.00950208

Aspects of immune dysfunction in end-stage renal disease. / Kato, Sawako; Chmielewski, Michal; Honda, Hirokazu; Pecoits-Filho, Roberto; Matsuo, Seiichi; Yuzawa, Yukio; Tranaeus, Anders; Stenvinkel, Peter; Lindholm, Bengt.

In: Clinical Journal of the American Society of Nephrology, Vol. 3, No. 5, 01.09.2008, p. 1526-1533.

Research output: Contribution to journalReview article

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AU - Chmielewski, Michal

AU - Honda, Hirokazu

AU - Pecoits-Filho, Roberto

AU - Matsuo, Seiichi

AU - Yuzawa, Yukio

AU - Tranaeus, Anders

AU - Stenvinkel, Peter

AU - Lindholm, Bengt

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