Aspergillus meningitis in a patient with chronic lymphocytic leukemia

Takahiro Matsuo; Nobuyoshi Mori; Aki Sakurai; Keiichi Furukawa

doi:10.1016/j.jiac.2020.01.012

Aspergillus meningitis in a patient with chronic lymphocytic leukemia

Takahiro Matsuo, Nobuyoshi Mori, Aki Sakurai, Keiichi Furukawa

Research output: Contribution to journal › Article › peer-review

Abstract

Central nervous system aspergillosis is relatively rare and difficult to diagnose. Here, we report a case of 90-year-old man with chronic lymphocytic leukemia who presented with a month-long gradually worsening headache followed by 3 days of low-grade fever associated with altered mental status. Aspergillus meningitis diagnosed using Aspergillus galactomannan antigen in the cerebrospinal fluid and treated with voriconazole. Delayed diagnosis and treatment of Aspergillus meningitis is typically associated with high mortality; therefore, it is imperative to include this disease in the differential diagnoses of subacute meningitis.

Original language	English
Pages (from-to)	622-624
Number of pages	3
Journal	Journal of Infection and Chemotherapy
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/j.jiac.2020.01.012
Publication status	Published - 06-2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

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title = "Aspergillus meningitis in a patient with chronic lymphocytic leukemia",

abstract = "Central nervous system aspergillosis is relatively rare and difficult to diagnose. Here, we report a case of 90-year-old man with chronic lymphocytic leukemia who presented with a month-long gradually worsening headache followed by 3 days of low-grade fever associated with altered mental status. Aspergillus meningitis diagnosed using Aspergillus galactomannan antigen in the cerebrospinal fluid and treated with voriconazole. Delayed diagnosis and treatment of Aspergillus meningitis is typically associated with high mortality; therefore, it is imperative to include this disease in the differential diagnoses of subacute meningitis.",

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AB - Central nervous system aspergillosis is relatively rare and difficult to diagnose. Here, we report a case of 90-year-old man with chronic lymphocytic leukemia who presented with a month-long gradually worsening headache followed by 3 days of low-grade fever associated with altered mental status. Aspergillus meningitis diagnosed using Aspergillus galactomannan antigen in the cerebrospinal fluid and treated with voriconazole. Delayed diagnosis and treatment of Aspergillus meningitis is typically associated with high mortality; therefore, it is imperative to include this disease in the differential diagnoses of subacute meningitis.

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