Assessment of injured spinal cord using diffusion tensor tractography

Kanehiro Fujiyoshi, Tsunehiko Konomi, Osahiko Tsuji, Masayuki Yamada, Keigo Hikishima, Suketaka Momoshima, Hideyuki Okano, Yoshiaki Toyama, Masaya Nakamura

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In spinal cord injury (SCI), the evaluation of axonal fibers is important to assess the severity of injury and efficacy of any treatment protocol, but conventional methods such as tracer injection in the brain parenchyma are highly invasive and require histological evaluation, precluding clinical applications. Magnetic resonance imaging (MRI) is essential for predicting prognosis and planning treatment of patients with SCI noninvasively. However, the information provided by conventional T1- and T2-weighted MRI of the spinal cord is essentially limited to the differentiation of the white matter from the gray matter. By contrast, diffusion-weighted magnetic resonance imaging (DWI) provides much information about biological structures. In particular, diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) are powerful tools for evaluating white matter fibers in the central nervous system. We previously established a reproducible SCI model in adult common marmosets and demonstrated that DTT could be used to trace the neural tracts in the intact and injured spinal cord of these animals in vivo. Recently, many reports using DTT to analyze the spinal cord area have been published. Based on the findings from our experimental studies, we are now routinely performing DTT of the human spinal cord clinically. In this chapter, we outline the basic principles of DTT and describe the characteristics, limitations, and clinical application of DTT in the spinal cord.

Original languageEnglish
Title of host publicationNeuroprotection and Regeneration of the Spinal Cord
PublisherSpringer Japan
Pages345-365
Number of pages21
Volume9784431545026
ISBN (Electronic)9784431545026
ISBN (Print)4431545018, 9784431545019
DOIs
Publication statusPublished - 01-11-2014

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Diffusion Tensor Imaging
Spinal Cord
Spinal Cord Injuries
Magnetic Resonance Imaging
Callithrix
Diffusion Magnetic Resonance Imaging
Clinical Protocols
Central Nervous System
Injections
Wounds and Injuries
Brain

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Fujiyoshi, K., Konomi, T., Tsuji, O., Yamada, M., Hikishima, K., Momoshima, S., ... Nakamura, M. (2014). Assessment of injured spinal cord using diffusion tensor tractography. In Neuroprotection and Regeneration of the Spinal Cord (Vol. 9784431545026, pp. 345-365). Springer Japan. https://doi.org/10.1007/978-4-431-54502-6_28
Fujiyoshi, Kanehiro ; Konomi, Tsunehiko ; Tsuji, Osahiko ; Yamada, Masayuki ; Hikishima, Keigo ; Momoshima, Suketaka ; Okano, Hideyuki ; Toyama, Yoshiaki ; Nakamura, Masaya. / Assessment of injured spinal cord using diffusion tensor tractography. Neuroprotection and Regeneration of the Spinal Cord. Vol. 9784431545026 Springer Japan, 2014. pp. 345-365
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Fujiyoshi, K, Konomi, T, Tsuji, O, Yamada, M, Hikishima, K, Momoshima, S, Okano, H, Toyama, Y & Nakamura, M 2014, Assessment of injured spinal cord using diffusion tensor tractography. in Neuroprotection and Regeneration of the Spinal Cord. vol. 9784431545026, Springer Japan, pp. 345-365. https://doi.org/10.1007/978-4-431-54502-6_28

Assessment of injured spinal cord using diffusion tensor tractography. / Fujiyoshi, Kanehiro; Konomi, Tsunehiko; Tsuji, Osahiko; Yamada, Masayuki; Hikishima, Keigo; Momoshima, Suketaka; Okano, Hideyuki; Toyama, Yoshiaki; Nakamura, Masaya.

Neuroprotection and Regeneration of the Spinal Cord. Vol. 9784431545026 Springer Japan, 2014. p. 345-365.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Fujiyoshi K, Konomi T, Tsuji O, Yamada M, Hikishima K, Momoshima S et al. Assessment of injured spinal cord using diffusion tensor tractography. In Neuroprotection and Regeneration of the Spinal Cord. Vol. 9784431545026. Springer Japan. 2014. p. 345-365 https://doi.org/10.1007/978-4-431-54502-6_28