Assessment of the latent adverse events of antipsychotic treatment using a subjective questionnaire in Japanese patients with schizophrenia

Masakazu Hatano, Hiroyuki Kamei, Azusa Kato, Ippei Takeuchi, Manako Hanya, Junji Uno, Shigeki Yamada, Kiyoshi Fujita, Nakao Iwata

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: The adverse effects of antipsychotic agents can have a marked influence on medication adherence. In this study, we investigated the adverse events of antipsychotics that are less likely to be reported by patients and the reasons why such symptoms remain latent. Methods: Data were collected by interviewing patients using a subjective questionnaire, and the associations between unreported symptoms and background factors were investigated. Results: A total of 306 patients with schizophrenia or schizoaffective disorder were examined. Their major symptoms were daytime sleepiness (50.0%), weight gain (42.2%), and sexual dysfunction (38.9%). Sexual dysfunction was nominal significantly more common among the patients that had been treated with antipsychotic agent polypharmacy (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.07 to 4.30), and was nominal significantly more common among outpatients (OR, 1.78; 95% CI, 1.02 to 3.13). Only approximately 30% of the patients had reported their symptoms to their physicians. Conclusion: Patients receiving antipsychotic treatment tolerate some symptoms and do not feel able to report them to their physicians. The most common reason for this is an insufficient patient-physician relationship. Sexual dysfunction is especially hard to identify because it is a delicate problem, and our findings demonstrate that subjective questionnaires are helpful for detecting such symptoms.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalClinical Psychopharmacology and Neuroscience
Volume15
Issue number2
DOIs
Publication statusPublished - 01-01-2017

Fingerprint

Antipsychotic Agents
Schizophrenia
Therapeutics
Odds Ratio
Confidence Intervals
Physicians
Physician-Patient Relations
Polypharmacy
Medication Adherence
Psychotic Disorders
Weight Gain
Surveys and Questionnaires
Outpatients

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Pharmacology (medical)

Cite this

Hatano, Masakazu ; Kamei, Hiroyuki ; Kato, Azusa ; Takeuchi, Ippei ; Hanya, Manako ; Uno, Junji ; Yamada, Shigeki ; Fujita, Kiyoshi ; Iwata, Nakao. / Assessment of the latent adverse events of antipsychotic treatment using a subjective questionnaire in Japanese patients with schizophrenia. In: Clinical Psychopharmacology and Neuroscience. 2017 ; Vol. 15, No. 2. pp. 132-137.
@article{8a6371af3aa4414baa8088b24f4f387a,
title = "Assessment of the latent adverse events of antipsychotic treatment using a subjective questionnaire in Japanese patients with schizophrenia",
abstract = "Objective: The adverse effects of antipsychotic agents can have a marked influence on medication adherence. In this study, we investigated the adverse events of antipsychotics that are less likely to be reported by patients and the reasons why such symptoms remain latent. Methods: Data were collected by interviewing patients using a subjective questionnaire, and the associations between unreported symptoms and background factors were investigated. Results: A total of 306 patients with schizophrenia or schizoaffective disorder were examined. Their major symptoms were daytime sleepiness (50.0{\%}), weight gain (42.2{\%}), and sexual dysfunction (38.9{\%}). Sexual dysfunction was nominal significantly more common among the patients that had been treated with antipsychotic agent polypharmacy (odds ratio [OR], 2.14; 95{\%} confidence interval [CI], 1.07 to 4.30), and was nominal significantly more common among outpatients (OR, 1.78; 95{\%} CI, 1.02 to 3.13). Only approximately 30{\%} of the patients had reported their symptoms to their physicians. Conclusion: Patients receiving antipsychotic treatment tolerate some symptoms and do not feel able to report them to their physicians. The most common reason for this is an insufficient patient-physician relationship. Sexual dysfunction is especially hard to identify because it is a delicate problem, and our findings demonstrate that subjective questionnaires are helpful for detecting such symptoms.",
author = "Masakazu Hatano and Hiroyuki Kamei and Azusa Kato and Ippei Takeuchi and Manako Hanya and Junji Uno and Shigeki Yamada and Kiyoshi Fujita and Nakao Iwata",
year = "2017",
month = "1",
day = "1",
doi = "10.9758/cpn.2017.15.2.132",
language = "English",
volume = "15",
pages = "132--137",
journal = "Clinical Psychopharmacology and Neuroscience",
issn = "1738-1088",
publisher = "Korean College of Neuropsychopharmacology",
number = "2",

}

Assessment of the latent adverse events of antipsychotic treatment using a subjective questionnaire in Japanese patients with schizophrenia. / Hatano, Masakazu; Kamei, Hiroyuki; Kato, Azusa; Takeuchi, Ippei; Hanya, Manako; Uno, Junji; Yamada, Shigeki; Fujita, Kiyoshi; Iwata, Nakao.

In: Clinical Psychopharmacology and Neuroscience, Vol. 15, No. 2, 01.01.2017, p. 132-137.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Assessment of the latent adverse events of antipsychotic treatment using a subjective questionnaire in Japanese patients with schizophrenia

AU - Hatano, Masakazu

AU - Kamei, Hiroyuki

AU - Kato, Azusa

AU - Takeuchi, Ippei

AU - Hanya, Manako

AU - Uno, Junji

AU - Yamada, Shigeki

AU - Fujita, Kiyoshi

AU - Iwata, Nakao

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective: The adverse effects of antipsychotic agents can have a marked influence on medication adherence. In this study, we investigated the adverse events of antipsychotics that are less likely to be reported by patients and the reasons why such symptoms remain latent. Methods: Data were collected by interviewing patients using a subjective questionnaire, and the associations between unreported symptoms and background factors were investigated. Results: A total of 306 patients with schizophrenia or schizoaffective disorder were examined. Their major symptoms were daytime sleepiness (50.0%), weight gain (42.2%), and sexual dysfunction (38.9%). Sexual dysfunction was nominal significantly more common among the patients that had been treated with antipsychotic agent polypharmacy (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.07 to 4.30), and was nominal significantly more common among outpatients (OR, 1.78; 95% CI, 1.02 to 3.13). Only approximately 30% of the patients had reported their symptoms to their physicians. Conclusion: Patients receiving antipsychotic treatment tolerate some symptoms and do not feel able to report them to their physicians. The most common reason for this is an insufficient patient-physician relationship. Sexual dysfunction is especially hard to identify because it is a delicate problem, and our findings demonstrate that subjective questionnaires are helpful for detecting such symptoms.

AB - Objective: The adverse effects of antipsychotic agents can have a marked influence on medication adherence. In this study, we investigated the adverse events of antipsychotics that are less likely to be reported by patients and the reasons why such symptoms remain latent. Methods: Data were collected by interviewing patients using a subjective questionnaire, and the associations between unreported symptoms and background factors were investigated. Results: A total of 306 patients with schizophrenia or schizoaffective disorder were examined. Their major symptoms were daytime sleepiness (50.0%), weight gain (42.2%), and sexual dysfunction (38.9%). Sexual dysfunction was nominal significantly more common among the patients that had been treated with antipsychotic agent polypharmacy (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.07 to 4.30), and was nominal significantly more common among outpatients (OR, 1.78; 95% CI, 1.02 to 3.13). Only approximately 30% of the patients had reported their symptoms to their physicians. Conclusion: Patients receiving antipsychotic treatment tolerate some symptoms and do not feel able to report them to their physicians. The most common reason for this is an insufficient patient-physician relationship. Sexual dysfunction is especially hard to identify because it is a delicate problem, and our findings demonstrate that subjective questionnaires are helpful for detecting such symptoms.

UR - http://www.scopus.com/inward/record.url?scp=85019254416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019254416&partnerID=8YFLogxK

U2 - 10.9758/cpn.2017.15.2.132

DO - 10.9758/cpn.2017.15.2.132

M3 - Article

AN - SCOPUS:85019254416

VL - 15

SP - 132

EP - 137

JO - Clinical Psychopharmacology and Neuroscience

JF - Clinical Psychopharmacology and Neuroscience

SN - 1738-1088

IS - 2

ER -