Assessment of the renal angina index in patients hospitalized in a cardiac intensive care unit

Eirin Sakaguchi; Hiroyuki Naruse; Yuya Ishihara; Hidekazu Hattori; Akira Yamada; Hideki Kawai; Takashi Muramatsu; Yoshiki Tsuboi; Ryosuke Fujii; Koji Suzuki; Junnichi Ishii; Kuniaki Saito; Masayoshi Sarai; Masanobu Yanase; Yukio Ozaki; Hideo Izawa

doi:10.1038/s41598-023-51086-0

Assessment of the renal angina index in patients hospitalized in a cardiac intensive care unit

Eirin Sakaguchi, Hiroyuki Naruse, Yuya Ishihara, Hidekazu Hattori, Akira Yamada, Hideki Kawai, Takashi Muramatsu, Yoshiki Tsuboi, Ryosuke Fujii, Koji Suzuki, Junnichi Ishii, Kuniaki Saito, Masayoshi Sarai, Masanobu Yanase, Yukio Ozaki, Hideo Izawa

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Abstract

The renal angina index (RAI) is a validated scoring tool for predicting acute kidney injury (AKI). We investigated the efficacy of the RAI in 2436 heterogeneous patients (mean age, 70 years) treated in cardiac intensive care units (CICUs). The RAI was calculated from creatinine and patient condition scores. AKI was diagnosed by the Kidney Disease: Improving Global Outcome criteria. The primary and secondary endpoints were the development of severe AKI and all-cause mortality, respectively. Four hundred thirty-three patients developed AKI, 87 of them severe. In multivariate analyses, the RAI was a significant independent predictor of severe AKI. During the 12-month follow-up period, 210 patients suffered all-cause death. Elevated RAI was independently associated with all-cause mortality, as was NT-proBNP (p < 0.001). The RAI is a potent predictor not only of severe AKI but also of adverse outcomes and substantially improved the 12-month risk stratification of patients hospitalized in CICUs.

Original language	English
Article number	75
Journal	Scientific reports
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/s41598-023-51086-0
Publication status	Published - 12-2024

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Sakaguchi, E., Naruse, H., Ishihara, Y., Hattori, H., Yamada, A., Kawai, H., Muramatsu, T., Tsuboi, Y., Fujii, R., Suzuki, K., Ishii, J., Saito, K., Sarai, M., Yanase, M., Ozaki, Y., & Izawa, H. (2024). Assessment of the renal angina index in patients hospitalized in a cardiac intensive care unit. Scientific reports, 14(1), Article 75. https://doi.org/10.1038/s41598-023-51086-0

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abstract = "The renal angina index (RAI) is a validated scoring tool for predicting acute kidney injury (AKI). We investigated the efficacy of the RAI in 2436 heterogeneous patients (mean age, 70 years) treated in cardiac intensive care units (CICUs). The RAI was calculated from creatinine and patient condition scores. AKI was diagnosed by the Kidney Disease: Improving Global Outcome criteria. The primary and secondary endpoints were the development of severe AKI and all-cause mortality, respectively. Four hundred thirty-three patients developed AKI, 87 of them severe. In multivariate analyses, the RAI was a significant independent predictor of severe AKI. During the 12-month follow-up period, 210 patients suffered all-cause death. Elevated RAI was independently associated with all-cause mortality, as was NT-proBNP (p < 0.001). The RAI is a potent predictor not only of severe AKI but also of adverse outcomes and substantially improved the 12-month risk stratification of patients hospitalized in CICUs.",

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AU - Sakaguchi, Eirin

AU - Naruse, Hiroyuki

AU - Ishihara, Yuya

AU - Hattori, Hidekazu

AU - Yamada, Akira

AU - Kawai, Hideki

AU - Muramatsu, Takashi

AU - Tsuboi, Yoshiki

AU - Fujii, Ryosuke

AU - Suzuki, Koji

AU - Ishii, Junnichi

AU - Saito, Kuniaki

AU - Sarai, Masayoshi

AU - Yanase, Masanobu

AU - Ozaki, Yukio

AU - Izawa, Hideo

PY - 2024/12

Y1 - 2024/12

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Assessment of the renal angina index in patients hospitalized in a cardiac intensive care unit

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