Association analysis between schizophrenia and the AP-3 complex genes

Ryota Hashimoto; Kazutaka Ohi; Takeya Okada; Yuka Yasuda; Hidenaga Yamamori; Hiroaki Hori; Takao Hikita; Shinichiro Taya; Osamu Saitoh; Asako Kosuga; Masahiko Tatsumi; Kunitoshi Kamijima; Kozo Kaibuchi; Masatoshi Takeda; Hiroshi Kunugi

doi:10.1016/j.neures.2009.05.008

Association analysis between schizophrenia and the AP-3 complex genes

Ryota Hashimoto, Kazutaka Ohi, Takeya Okada, Yuka Yasuda, Hidenaga Yamamori, Hiroaki Hori, Takao Hikita, Shinichiro Taya, Osamu Saitoh, Asako Kosuga, Masahiko Tatsumi, Kunitoshi Kamijima, Kozo Kaibuchi, Masatoshi Takeda, Hiroshi Kunugi

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (χ² = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.

Original language	English
Pages (from-to)	113-115
Number of pages	3
Journal	Neuroscience Research
Volume	65
Issue number	1
DOIs	https://doi.org/10.1016/j.neures.2009.05.008
Publication status	Published - 09-2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neures.2009.05.008

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title = "Association analysis between schizophrenia and the AP-3 complex genes",

abstract = "A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (χ2 = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.",

keywords = "AP3M1, Adaptor protein (AP)-3 complex, Dysbindin, Schizophrenia, Single nucleotide polymorphism",

author = "Ryota Hashimoto and Kazutaka Ohi and Takeya Okada and Yuka Yasuda and Hidenaga Yamamori and Hiroaki Hori and Takao Hikita and Shinichiro Taya and Osamu Saitoh and Asako Kosuga and Masahiko Tatsumi and Kunitoshi Kamijima and Kozo Kaibuchi and Masatoshi Takeda and Hiroshi Kunugi",

note = "Funding Information: This work was supported in part by Grants-in-Aid from the Japanese Ministry of Health, Labor and Welfare (H18-kokoro-005, H19-kokoro-002). ",

year = "2009",

month = sep,

doi = "10.1016/j.neures.2009.05.008",

language = "English",

volume = "65",

pages = "113--115",

journal = "Neuroscience Research",

issn = "0168-0102",

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TY - JOUR

T1 - Association analysis between schizophrenia and the AP-3 complex genes

AU - Hashimoto, Ryota

AU - Ohi, Kazutaka

AU - Okada, Takeya

AU - Yasuda, Yuka

AU - Yamamori, Hidenaga

AU - Hori, Hiroaki

AU - Hikita, Takao

AU - Taya, Shinichiro

AU - Saitoh, Osamu

AU - Kosuga, Asako

AU - Tatsumi, Masahiko

AU - Kamijima, Kunitoshi

AU - Kaibuchi, Kozo

AU - Takeda, Masatoshi

AU - Kunugi, Hiroshi

N1 - Funding Information: This work was supported in part by Grants-in-Aid from the Japanese Ministry of Health, Labor and Welfare (H18-kokoro-005, H19-kokoro-002).

PY - 2009/9

Y1 - 2009/9

N2 - A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (χ2 = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.

AB - A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (χ2 = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.

KW - AP3M1

KW - Adaptor protein (AP)-3 complex

KW - Dysbindin

KW - Schizophrenia

KW - Single nucleotide polymorphism

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SP - 113

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JO - Neuroscience Research

JF - Neuroscience Research

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Association analysis between schizophrenia and the AP-3 complex genes

Abstract

All Science Journal Classification (ASJC) codes

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