Association analysis between schizophrenia and the AP-3 complex genes

Ryota Hashimoto, Kazutaka Ohi, Takeya Okada, Yuka Yasuda, Hidenaga Yamamori, Hiroaki Hori, Takao Hikita, Shinichiro Taya, Osamu Saitoh, Asako Kosuga, Masahiko Tatsumi, Kunitoshi Kamijima, Kozo Kaibuchi, Masatoshi Takeda, Hiroshi Kunugi

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6 Citations (Scopus)

Abstract

A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (χ2 = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.

Original languageEnglish
Pages (from-to)113-115
Number of pages3
JournalNeuroscience Research
Volume65
Issue number1
DOIs
Publication statusPublished - 01-09-2009

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Hashimoto, R., Ohi, K., Okada, T., Yasuda, Y., Yamamori, H., Hori, H., Hikita, T., Taya, S., Saitoh, O., Kosuga, A., Tatsumi, M., Kamijima, K., Kaibuchi, K., Takeda, M., & Kunugi, H. (2009). Association analysis between schizophrenia and the AP-3 complex genes. Neuroscience Research, 65(1), 113-115. https://doi.org/10.1016/j.neures.2009.05.008