Association analysis of δ-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis

Hideaki Kobayashi, Harumi Hata, Hiroshi Ujike, Mutsuo Harano, Toshiya Inada, Tokutaro Komiyama, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Maki Naka, Soichiro Ide, Kazutaka Ikeda, Yohtaro Numachi, Ichiro Sora

Research output: Contribution to journalArticle

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Abstract

The role of the δ-opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon-intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis.

Original languageEnglish
Pages (from-to)482-486
Number of pages5
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume141
Issue number5
DOIs
Publication statusPublished - 05-07-2006

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Methamphetamine
Opioid Receptors
Psychotic Disorders
Single Nucleotide Polymorphism
Exons
Genes
Introns
Linkage Disequilibrium
DNA

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Kobayashi, Hideaki ; Hata, Harumi ; Ujike, Hiroshi ; Harano, Mutsuo ; Inada, Toshiya ; Komiyama, Tokutaro ; Yamada, Mitsuhiko ; Sekine, Yoshimoto ; Iwata, Nakao ; Iyo, Masaomi ; Ozaki, Norio ; Itokawa, Masanari ; Naka, Maki ; Ide, Soichiro ; Ikeda, Kazutaka ; Numachi, Yohtaro ; Sora, Ichiro. / Association analysis of δ-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2006 ; Vol. 141, No. 5. pp. 482-486.
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Kobayashi, H, Hata, H, Ujike, H, Harano, M, Inada, T, Komiyama, T, Yamada, M, Sekine, Y, Iwata, N, Iyo, M, Ozaki, N, Itokawa, M, Naka, M, Ide, S, Ikeda, K, Numachi, Y & Sora, I 2006, 'Association analysis of δ-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 141, no. 5, pp. 482-486. https://doi.org/10.1002/ajmg.b.30337

Association analysis of δ-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. / Kobayashi, Hideaki; Hata, Harumi; Ujike, Hiroshi; Harano, Mutsuo; Inada, Toshiya; Komiyama, Tokutaro; Yamada, Mitsuhiko; Sekine, Yoshimoto; Iwata, Nakao; Iyo, Masaomi; Ozaki, Norio; Itokawa, Masanari; Naka, Maki; Ide, Soichiro; Ikeda, Kazutaka; Numachi, Yohtaro; Sora, Ichiro.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 141, No. 5, 05.07.2006, p. 482-486.

Research output: Contribution to journalArticle

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T1 - Association analysis of δ-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis

AU - Kobayashi, Hideaki

AU - Hata, Harumi

AU - Ujike, Hiroshi

AU - Harano, Mutsuo

AU - Inada, Toshiya

AU - Komiyama, Tokutaro

AU - Yamada, Mitsuhiko

AU - Sekine, Yoshimoto

AU - Iwata, Nakao

AU - Iyo, Masaomi

AU - Ozaki, Norio

AU - Itokawa, Masanari

AU - Naka, Maki

AU - Ide, Soichiro

AU - Ikeda, Kazutaka

AU - Numachi, Yohtaro

AU - Sora, Ichiro

PY - 2006/7/5

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N2 - The role of the δ-opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon-intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis.

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