Association analysis of δ-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis

Hideaki Kobayashi; Harumi Hata; Hiroshi Ujike; Mutsuo Harano; Toshiya Inada; Tokutaro Komiyama; Mitsuhiko Yamada; Yoshimoto Sekine; Nakao Iwata; Masaomi Iyo; Norio Ozaki; Masanari Itokawa; Maki Naka; Soichiro Ide; Kazutaka Ikeda; Yohtaro Numachi; Ichiro Sora

doi:10.1002/ajmg.b.30337

Association analysis of δ-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis

Hideaki Kobayashi, Harumi Hata, Hiroshi Ujike, Mutsuo Harano, Toshiya Inada, Tokutaro Komiyama, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Maki Naka, Soichiro Ide, Kazutaka Ikeda, Yohtaro Numachi, Ichiro Sora

Psychiatry

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The role of the δ-opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon-intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis.

Original language	English
Pages (from-to)	482-486
Number of pages	5
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	141
Issue number	5
DOIs	https://doi.org/10.1002/ajmg.b.30337
Publication status	Published - 05-07-2006

All Science Journal Classification (ASJC) codes

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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Kobayashi, H., Hata, H., Ujike, H., Harano, M., Inada, T., Komiyama, T., Yamada, M., Sekine, Y., Iwata, N., Iyo, M., Ozaki, N., Itokawa, M., Naka, M., Ide, S., Ikeda, K., Numachi, Y., & Sora, I. (2006). Association analysis of δ-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 141(5), 482-486. https://doi.org/10.1002/ajmg.b.30337

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title = "Association analysis of δ-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis",

abstract = "The role of the δ-opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon-intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis.",

author = "Hideaki Kobayashi and Harumi Hata and Hiroshi Ujike and Mutsuo Harano and Toshiya Inada and Tokutaro Komiyama and Mitsuhiko Yamada and Yoshimoto Sekine and Nakao Iwata and Masaomi Iyo and Norio Ozaki and Masanari Itokawa and Maki Naka and Soichiro Ide and Kazutaka Ikeda and Yohtaro Numachi and Ichiro Sora",

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Kobayashi, H, Hata, H, Ujike, H, Harano, M, Inada, T, Komiyama, T, Yamada, M, Sekine, Y, Iwata, N, Iyo, M, Ozaki, N, Itokawa, M, Naka, M, Ide, S, Ikeda, K, Numachi, Y & Sora, I 2006, 'Association analysis of δ-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 141, no. 5, pp. 482-486. https://doi.org/10.1002/ajmg.b.30337

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AU - Kobayashi, Hideaki

AU - Hata, Harumi

AU - Ujike, Hiroshi

AU - Harano, Mutsuo

AU - Inada, Toshiya

AU - Komiyama, Tokutaro

AU - Yamada, Mitsuhiko

AU - Sekine, Yoshimoto

AU - Iwata, Nakao

AU - Iyo, Masaomi

AU - Ozaki, Norio

AU - Itokawa, Masanari

AU - Naka, Maki

AU - Ide, Soichiro

AU - Ikeda, Kazutaka

AU - Numachi, Yohtaro

AU - Sora, Ichiro

PY - 2006/7/5

Y1 - 2006/7/5

N2 - The role of the δ-opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon-intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis.

AB - The role of the δ-opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon-intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis.

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Association analysis of δ-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis

Abstract

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