Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population

Tomoko Tsunoka, Taro Kishi, Tsuyoshi Kitajima, Tomo Okochi, Takenori Okumura, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Hiroshi Naitoh, Toshiya Inada, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Abnormalities in glutaminergic neural transmission have been suggested to be involved in the pathogenesis of schizophrenia. A recent study reported that alterations in the 5-HT2A-mGluR2 complex may be involved in neural transmission in the schizophrenic cortex. In addition, methamphetamine-induced psychosis is thought to be similar to schizophrenia. Therefore, we conducted a case-control study with Japanese samples (738 schizophrenia patients, 196 methamphetamine-induced psychosis patients, and 802 controls) to evaluate the association and interaction between GRM2, HTR2A and schizophrenia. Methods: We selected three 'tagging SNPs' in GRM2, and two biologically functional SNPs in HTR2A (T102C and A1438G), for the association analysis. Results: We detected a significant association between methamphetamine-induced psychosis and GRM2 in a haplotype-wise analysis, but not HTR2A. We did not detect an association between GRM2 or HTR2A and schizophrenia. In addition, no interactions of GRM2 and HTR2A were found in methamphetamine-induced psychosis or schizophrenia. We did not detect any novel polymorphisms in GRM2 when we performed a mutation search using methamphetamine-induced psychosis samples. Conclusion: Our results suggested that GRM2 may play a role in the pathophysiology of methamphetamine-induced psychosis but not schizophrenia in the Japanese population. A replication study using larger samples or samples of other populations will be required for conclusive results.

Original languageEnglish
Pages (from-to)639-644
Number of pages6
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume34
Issue number4
DOIs
Publication statusPublished - 01-05-2010

Fingerprint

Methamphetamine
Psychotic Disorders
Schizophrenia
Population
Synaptic Transmission
Single Nucleotide Polymorphism
Haplotypes
Case-Control Studies
Mutation

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

Cite this

Tsunoka, Tomoko ; Kishi, Taro ; Kitajima, Tsuyoshi ; Okochi, Tomo ; Okumura, Takenori ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Kawashima, Kunihiro ; Naitoh, Hiroshi ; Inada, Toshiya ; Ujike, Hiroshi ; Yamada, Mitsuhiko ; Uchimura, Naohisa ; Sora, Ichiro ; Iyo, Masaomi ; Ozaki, Norio ; Iwata, Nakao. / Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2010 ; Vol. 34, No. 4. pp. 639-644.
@article{1fcee6ac642a4eb6b59caf5d3355bbe3,
title = "Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population",
abstract = "Background: Abnormalities in glutaminergic neural transmission have been suggested to be involved in the pathogenesis of schizophrenia. A recent study reported that alterations in the 5-HT2A-mGluR2 complex may be involved in neural transmission in the schizophrenic cortex. In addition, methamphetamine-induced psychosis is thought to be similar to schizophrenia. Therefore, we conducted a case-control study with Japanese samples (738 schizophrenia patients, 196 methamphetamine-induced psychosis patients, and 802 controls) to evaluate the association and interaction between GRM2, HTR2A and schizophrenia. Methods: We selected three 'tagging SNPs' in GRM2, and two biologically functional SNPs in HTR2A (T102C and A1438G), for the association analysis. Results: We detected a significant association between methamphetamine-induced psychosis and GRM2 in a haplotype-wise analysis, but not HTR2A. We did not detect an association between GRM2 or HTR2A and schizophrenia. In addition, no interactions of GRM2 and HTR2A were found in methamphetamine-induced psychosis or schizophrenia. We did not detect any novel polymorphisms in GRM2 when we performed a mutation search using methamphetamine-induced psychosis samples. Conclusion: Our results suggested that GRM2 may play a role in the pathophysiology of methamphetamine-induced psychosis but not schizophrenia in the Japanese population. A replication study using larger samples or samples of other populations will be required for conclusive results.",
author = "Tomoko Tsunoka and Taro Kishi and Tsuyoshi Kitajima and Tomo Okochi and Takenori Okumura and Yoshio Yamanouchi and Yoko Kinoshita and Kunihiro Kawashima and Hiroshi Naitoh and Toshiya Inada and Hiroshi Ujike and Mitsuhiko Yamada and Naohisa Uchimura and Ichiro Sora and Masaomi Iyo and Norio Ozaki and Nakao Iwata",
year = "2010",
month = "5",
day = "1",
doi = "10.1016/j.pnpbp.2010.03.002",
language = "English",
volume = "34",
pages = "639--644",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",
number = "4",

}

Tsunoka, T, Kishi, T, Kitajima, T, Okochi, T, Okumura, T, Yamanouchi, Y, Kinoshita, Y, Kawashima, K, Naitoh, H, Inada, T, Ujike, H, Yamada, M, Uchimura, N, Sora, I, Iyo, M, Ozaki, N & Iwata, N 2010, 'Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 34, no. 4, pp. 639-644. https://doi.org/10.1016/j.pnpbp.2010.03.002

Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population. / Tsunoka, Tomoko; Kishi, Taro; Kitajima, Tsuyoshi; Okochi, Tomo; Okumura, Takenori; Yamanouchi, Yoshio; Kinoshita, Yoko; Kawashima, Kunihiro; Naitoh, Hiroshi; Inada, Toshiya; Ujike, Hiroshi; Yamada, Mitsuhiko; Uchimura, Naohisa; Sora, Ichiro; Iyo, Masaomi; Ozaki, Norio; Iwata, Nakao.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 34, No. 4, 01.05.2010, p. 639-644.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population

AU - Tsunoka, Tomoko

AU - Kishi, Taro

AU - Kitajima, Tsuyoshi

AU - Okochi, Tomo

AU - Okumura, Takenori

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Kawashima, Kunihiro

AU - Naitoh, Hiroshi

AU - Inada, Toshiya

AU - Ujike, Hiroshi

AU - Yamada, Mitsuhiko

AU - Uchimura, Naohisa

AU - Sora, Ichiro

AU - Iyo, Masaomi

AU - Ozaki, Norio

AU - Iwata, Nakao

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Background: Abnormalities in glutaminergic neural transmission have been suggested to be involved in the pathogenesis of schizophrenia. A recent study reported that alterations in the 5-HT2A-mGluR2 complex may be involved in neural transmission in the schizophrenic cortex. In addition, methamphetamine-induced psychosis is thought to be similar to schizophrenia. Therefore, we conducted a case-control study with Japanese samples (738 schizophrenia patients, 196 methamphetamine-induced psychosis patients, and 802 controls) to evaluate the association and interaction between GRM2, HTR2A and schizophrenia. Methods: We selected three 'tagging SNPs' in GRM2, and two biologically functional SNPs in HTR2A (T102C and A1438G), for the association analysis. Results: We detected a significant association between methamphetamine-induced psychosis and GRM2 in a haplotype-wise analysis, but not HTR2A. We did not detect an association between GRM2 or HTR2A and schizophrenia. In addition, no interactions of GRM2 and HTR2A were found in methamphetamine-induced psychosis or schizophrenia. We did not detect any novel polymorphisms in GRM2 when we performed a mutation search using methamphetamine-induced psychosis samples. Conclusion: Our results suggested that GRM2 may play a role in the pathophysiology of methamphetamine-induced psychosis but not schizophrenia in the Japanese population. A replication study using larger samples or samples of other populations will be required for conclusive results.

AB - Background: Abnormalities in glutaminergic neural transmission have been suggested to be involved in the pathogenesis of schizophrenia. A recent study reported that alterations in the 5-HT2A-mGluR2 complex may be involved in neural transmission in the schizophrenic cortex. In addition, methamphetamine-induced psychosis is thought to be similar to schizophrenia. Therefore, we conducted a case-control study with Japanese samples (738 schizophrenia patients, 196 methamphetamine-induced psychosis patients, and 802 controls) to evaluate the association and interaction between GRM2, HTR2A and schizophrenia. Methods: We selected three 'tagging SNPs' in GRM2, and two biologically functional SNPs in HTR2A (T102C and A1438G), for the association analysis. Results: We detected a significant association between methamphetamine-induced psychosis and GRM2 in a haplotype-wise analysis, but not HTR2A. We did not detect an association between GRM2 or HTR2A and schizophrenia. In addition, no interactions of GRM2 and HTR2A were found in methamphetamine-induced psychosis or schizophrenia. We did not detect any novel polymorphisms in GRM2 when we performed a mutation search using methamphetamine-induced psychosis samples. Conclusion: Our results suggested that GRM2 may play a role in the pathophysiology of methamphetamine-induced psychosis but not schizophrenia in the Japanese population. A replication study using larger samples or samples of other populations will be required for conclusive results.

UR - http://www.scopus.com/inward/record.url?scp=77952671499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952671499&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2010.03.002

DO - 10.1016/j.pnpbp.2010.03.002

M3 - Article

C2 - 20211215

AN - SCOPUS:77952671499

VL - 34

SP - 639

EP - 644

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

IS - 4

ER -