Association analysis of nuclear receptor rev-erb alpha gene (NR1D1) and Japanese methamphetamine dependence

Taro Kishi, Tsuyoshi Kitajima, Kunihiro Kawashima, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticle

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Abstract

Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha and glycogen synthase kinase-3 β (GSK-3β) were shown to be important circadian components. In addition, the orphan nuclear receptor rev-erb alpha is a key negative feedback regulator of the circadian clock. These evidences indicate that rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of methamphetamine dependence. To evaluate the association between NR1D1 and methamphetamine dependence, we conducted a case-control study of Japanese samples (215 methamphetamine dependence and 232 controls) with three tagging SNPs selected by HapMap database. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association between NR1D1 and Japanese methamphetamine dependence patients in allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest that NR1D1 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalCurrent Neuropharmacology
Volume9
Issue number1
DOIs
Publication statusPublished - 30-03-2011

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Nuclear Receptor Subfamily 1, Group D, Member 1
Methamphetamine
Orphan Nuclear Receptors
Genes
Substance-Related Disorders
HapMap Project
Ethics Committees
Circadian Clocks
Circadian Rhythm
Informed Consent
Haplotypes
Single Nucleotide Polymorphism
Psychiatry
Case-Control Studies
Alleles
Genotype
Medicine
Databases
Health

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Kishi, Taro ; Kitajima, Tsuyoshi ; Kawashima, Kunihiro ; Okochi, Tomo ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Ujike, Hiroshi ; Inada, Toshiya ; Yamada, Mitsuhiko ; Uchimura, Naohisa ; Sora, Ichiro ; Iyo, Masaomi ; Ozaki, Norio ; Iwata, Nakao. / Association analysis of nuclear receptor rev-erb alpha gene (NR1D1) and Japanese methamphetamine dependence. In: Current Neuropharmacology. 2011 ; Vol. 9, No. 1. pp. 129-132.
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abstract = "Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha and glycogen synthase kinase-3 β (GSK-3β) were shown to be important circadian components. In addition, the orphan nuclear receptor rev-erb alpha is a key negative feedback regulator of the circadian clock. These evidences indicate that rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of methamphetamine dependence. To evaluate the association between NR1D1 and methamphetamine dependence, we conducted a case-control study of Japanese samples (215 methamphetamine dependence and 232 controls) with three tagging SNPs selected by HapMap database. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association between NR1D1 and Japanese methamphetamine dependence patients in allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest that NR1D1 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population.",
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Kishi, T, Kitajima, T, Kawashima, K, Okochi, T, Yamanouchi, Y, Kinoshita, Y, Ujike, H, Inada, T, Yamada, M, Uchimura, N, Sora, I, Iyo, M, Ozaki, N & Iwata, N 2011, 'Association analysis of nuclear receptor rev-erb alpha gene (NR1D1) and Japanese methamphetamine dependence', Current Neuropharmacology, vol. 9, no. 1, pp. 129-132. https://doi.org/10.2174/157015911795017065

Association analysis of nuclear receptor rev-erb alpha gene (NR1D1) and Japanese methamphetamine dependence. / Kishi, Taro; Kitajima, Tsuyoshi; Kawashima, Kunihiro; Okochi, Tomo; Yamanouchi, Yoshio; Kinoshita, Yoko; Ujike, Hiroshi; Inada, Toshiya; Yamada, Mitsuhiko; Uchimura, Naohisa; Sora, Ichiro; Iyo, Masaomi; Ozaki, Norio; Iwata, Nakao.

In: Current Neuropharmacology, Vol. 9, No. 1, 30.03.2011, p. 129-132.

Research output: Contribution to journalArticle

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T1 - Association analysis of nuclear receptor rev-erb alpha gene (NR1D1) and Japanese methamphetamine dependence

AU - Kishi, Taro

AU - Kitajima, Tsuyoshi

AU - Kawashima, Kunihiro

AU - Okochi, Tomo

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Ujike, Hiroshi

AU - Inada, Toshiya

AU - Yamada, Mitsuhiko

AU - Uchimura, Naohisa

AU - Sora, Ichiro

AU - Iyo, Masaomi

AU - Ozaki, Norio

AU - Iwata, Nakao

PY - 2011/3/30

Y1 - 2011/3/30

N2 - Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha and glycogen synthase kinase-3 β (GSK-3β) were shown to be important circadian components. In addition, the orphan nuclear receptor rev-erb alpha is a key negative feedback regulator of the circadian clock. These evidences indicate that rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of methamphetamine dependence. To evaluate the association between NR1D1 and methamphetamine dependence, we conducted a case-control study of Japanese samples (215 methamphetamine dependence and 232 controls) with three tagging SNPs selected by HapMap database. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association between NR1D1 and Japanese methamphetamine dependence patients in allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest that NR1D1 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population.

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