Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population

Taro Kishi, Tsuyoshi Kitajima, Masashi Ikeda, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Tomo Okochi, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Several investigations have suggested that alterations in circadian rhythms may lay the foundation for the development of mood disorder (bipolar disorder and major depressive disorder). Recently, the nuclear receptor Rev-erb alpha was reported to be related to circadian rhythms, and was shown to be involved in the biological action of lithium in vitro. These evidences indicate that the nuclear receptor Rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of mood disorders. To evaluate the association between NR1D1 and mood disorders, we conducted a case-control study of Japanese samples (147 bipolar patients, 322 major depressive disorder patients and 360 controls) with three tagging SNPs selected by HapMap database. One SNP showed an association with bipolar disorder in females. After Bonferroni correction for multiple testing, however, this significance disappeared. No significant association was found with major depressive disorder. In conclusion, our findings suggest that NR1D1 does not play a major role in the pathophysiology of mood disorders in the Japanese population. Crown

Original languageEnglish
Pages (from-to)211-215
Number of pages5
JournalNeuroscience Research
Volume62
Issue number4
DOIs
Publication statusPublished - 01-12-2008

Fingerprint

Nuclear Receptor Subfamily 1, Group D, Member 1
Mood Disorders
Major Depressive Disorder
Circadian Rhythm
Bipolar Disorder
Population
Genes
Single Nucleotide Polymorphism
HapMap Project
Crowns
Lithium
Case-Control Studies
Databases

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kishi, Taro ; Kitajima, Tsuyoshi ; Ikeda, Masashi ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Kawashima, Kunihiro ; Okochi, Tomo ; Ozaki, Norio ; Iwata, Nakao. / Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population. In: Neuroscience Research. 2008 ; Vol. 62, No. 4. pp. 211-215.
@article{05f96cd780ae4c54be8db5dd01767d07,
title = "Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population",
abstract = "Several investigations have suggested that alterations in circadian rhythms may lay the foundation for the development of mood disorder (bipolar disorder and major depressive disorder). Recently, the nuclear receptor Rev-erb alpha was reported to be related to circadian rhythms, and was shown to be involved in the biological action of lithium in vitro. These evidences indicate that the nuclear receptor Rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of mood disorders. To evaluate the association between NR1D1 and mood disorders, we conducted a case-control study of Japanese samples (147 bipolar patients, 322 major depressive disorder patients and 360 controls) with three tagging SNPs selected by HapMap database. One SNP showed an association with bipolar disorder in females. After Bonferroni correction for multiple testing, however, this significance disappeared. No significant association was found with major depressive disorder. In conclusion, our findings suggest that NR1D1 does not play a major role in the pathophysiology of mood disorders in the Japanese population. Crown",
author = "Taro Kishi and Tsuyoshi Kitajima and Masashi Ikeda and Yoshio Yamanouchi and Yoko Kinoshita and Kunihiro Kawashima and Tomo Okochi and Norio Ozaki and Nakao Iwata",
year = "2008",
month = "12",
day = "1",
doi = "10.1016/j.neures.2008.08.008",
language = "English",
volume = "62",
pages = "211--215",
journal = "Neuroscience Research",
issn = "0168-0102",
publisher = "Elsevier Ireland Ltd",
number = "4",

}

Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population. / Kishi, Taro; Kitajima, Tsuyoshi; Ikeda, Masashi; Yamanouchi, Yoshio; Kinoshita, Yoko; Kawashima, Kunihiro; Okochi, Tomo; Ozaki, Norio; Iwata, Nakao.

In: Neuroscience Research, Vol. 62, No. 4, 01.12.2008, p. 211-215.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population

AU - Kishi, Taro

AU - Kitajima, Tsuyoshi

AU - Ikeda, Masashi

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Kawashima, Kunihiro

AU - Okochi, Tomo

AU - Ozaki, Norio

AU - Iwata, Nakao

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Several investigations have suggested that alterations in circadian rhythms may lay the foundation for the development of mood disorder (bipolar disorder and major depressive disorder). Recently, the nuclear receptor Rev-erb alpha was reported to be related to circadian rhythms, and was shown to be involved in the biological action of lithium in vitro. These evidences indicate that the nuclear receptor Rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of mood disorders. To evaluate the association between NR1D1 and mood disorders, we conducted a case-control study of Japanese samples (147 bipolar patients, 322 major depressive disorder patients and 360 controls) with three tagging SNPs selected by HapMap database. One SNP showed an association with bipolar disorder in females. After Bonferroni correction for multiple testing, however, this significance disappeared. No significant association was found with major depressive disorder. In conclusion, our findings suggest that NR1D1 does not play a major role in the pathophysiology of mood disorders in the Japanese population. Crown

AB - Several investigations have suggested that alterations in circadian rhythms may lay the foundation for the development of mood disorder (bipolar disorder and major depressive disorder). Recently, the nuclear receptor Rev-erb alpha was reported to be related to circadian rhythms, and was shown to be involved in the biological action of lithium in vitro. These evidences indicate that the nuclear receptor Rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of mood disorders. To evaluate the association between NR1D1 and mood disorders, we conducted a case-control study of Japanese samples (147 bipolar patients, 322 major depressive disorder patients and 360 controls) with three tagging SNPs selected by HapMap database. One SNP showed an association with bipolar disorder in females. After Bonferroni correction for multiple testing, however, this significance disappeared. No significant association was found with major depressive disorder. In conclusion, our findings suggest that NR1D1 does not play a major role in the pathophysiology of mood disorders in the Japanese population. Crown

UR - http://www.scopus.com/inward/record.url?scp=55649113088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55649113088&partnerID=8YFLogxK

U2 - 10.1016/j.neures.2008.08.008

DO - 10.1016/j.neures.2008.08.008

M3 - Article

VL - 62

SP - 211

EP - 215

JO - Neuroscience Research

JF - Neuroscience Research

SN - 0168-0102

IS - 4

ER -