Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia

R. Hashimoto, M. Yoshida, N. Ozaki, Y. Yamanouchi, N. Iwata, T. Suzuki, T. Kitajima, M. Tatsumi, K. Kamijima, H. Kunugi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-α gene.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalJournal of Neural Transmission
Volume111
Issue number2
DOIs
Publication statusPublished - 02-2004

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia'. Together they form a unique fingerprint.

  • Cite this