Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia

R. Hashimoto, M. Yoshida, N. Ozaki, Y. Yamanouchi, N. Iwata, T. Suzuki, T. Kitajima, M. Tatsumi, K. Kamijima, H. Kunugi

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Abstract

Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-α gene.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalJournal of Neural Transmission
Volume111
Issue number2
DOIs
Publication statusPublished - 01-02-2004

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Schizophrenia
Tumor Necrosis Factor-alpha
Genes
Gene Frequency
Research

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Hashimoto, R. ; Yoshida, M. ; Ozaki, N. ; Yamanouchi, Y. ; Iwata, N. ; Suzuki, T. ; Kitajima, T. ; Tatsumi, M. ; Kamijima, K. ; Kunugi, H. / Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia. In: Journal of Neural Transmission. 2004 ; Vol. 111, No. 2. pp. 217-221.
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Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia. / Hashimoto, R.; Yoshida, M.; Ozaki, N.; Yamanouchi, Y.; Iwata, N.; Suzuki, T.; Kitajima, T.; Tatsumi, M.; Kamijima, K.; Kunugi, H.

In: Journal of Neural Transmission, Vol. 111, No. 2, 01.02.2004, p. 217-221.

Research output: Contribution to journalArticle

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T1 - Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia

AU - Hashimoto, R.

AU - Yoshida, M.

AU - Ozaki, N.

AU - Yamanouchi, Y.

AU - Iwata, N.

AU - Suzuki, T.

AU - Kitajima, T.

AU - Tatsumi, M.

AU - Kamijima, K.

AU - Kunugi, H.

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AB - Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-α gene.

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