Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia

R. Hashimoto; M. Yoshida; N. Ozaki; Y. Yamanouchi; N. Iwata; T. Suzuki; T. Kitajima; M. Tatsumi; K. Kamijima; H. Kunugi

doi:10.1007/s00702-003-0101-z

Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia

R. Hashimoto, M. Yoshida, N. Ozaki, Y. Yamanouchi, N. Iwata, T. Suzuki, T. Kitajima, M. Tatsumi, K. Kamijima, H. Kunugi

Psychiatry

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Abstract

Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-α gene.

Original language	English
Pages (from-to)	217-221
Number of pages	5
Journal	Journal of Neural Transmission
Volume	111
Issue number	2
DOIs	https://doi.org/10.1007/s00702-003-0101-z
Publication status	Published - 02-2004

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

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10.1007/s00702-003-0101-z

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Hashimoto, R., Yoshida, M., Ozaki, N., Yamanouchi, Y., Iwata, N., Suzuki, T., Kitajima, T., Tatsumi, M., Kamijima, K., & Kunugi, H. (2004). Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia. Journal of Neural Transmission, 111(2), 217-221. https://doi.org/10.1007/s00702-003-0101-z

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title = "Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia",

abstract = "Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-α gene.",

author = "R. Hashimoto and M. Yoshida and N. Ozaki and Y. Yamanouchi and N. Iwata and T. Suzuki and T. Kitajima and M. Tatsumi and K. Kamijima and H. Kunugi",

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Hashimoto, R, Yoshida, M, Ozaki, N, Yamanouchi, Y, Iwata, N, Suzuki, T, Kitajima, T, Tatsumi, M, Kamijima, K & Kunugi, H 2004, 'Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia', Journal of Neural Transmission, vol. 111, no. 2, pp. 217-221. https://doi.org/10.1007/s00702-003-0101-z

TY - JOUR

T1 - Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia

AU - Hashimoto, R.

AU - Yoshida, M.

AU - Ozaki, N.

AU - Yamanouchi, Y.

AU - Iwata, N.

AU - Suzuki, T.

AU - Kitajima, T.

AU - Tatsumi, M.

AU - Kamijima, K.

AU - Kunugi, H.

PY - 2004/2

Y1 - 2004/2

N2 - Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-α gene.

AB - Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-α gene.

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Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia

Abstract

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