TY - JOUR
T1 - Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia
AU - Hashimoto, R.
AU - Yoshida, M.
AU - Ozaki, N.
AU - Yamanouchi, Y.
AU - Iwata, N.
AU - Suzuki, T.
AU - Kitajima, T.
AU - Tatsumi, M.
AU - Kamijima, K.
AU - Kunugi, H.
PY - 2004/2
Y1 - 2004/2
N2 - Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-α gene.
AB - Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-α gene.
UR - https://www.scopus.com/pages/publications/10744229906
UR - https://www.scopus.com/pages/publications/10744229906#tab=citedBy
U2 - 10.1007/s00702-003-0101-z
DO - 10.1007/s00702-003-0101-z
M3 - Article
C2 - 14767724
AN - SCOPUS:10744229906
SN - 0300-9564
VL - 111
SP - 217
EP - 221
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 2
ER -
