Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population

Tomoko Yoshimura; Hinako Usui; Nagahide Takahashi; Akira Yoshimi; Shinichi Saito; Branko Aleksic; Hiroshi Ujike; Toshiya Inada; Mitsuhiko Yamada; Naohisa Uchimura; Nakao Iwata; Ichiro Sora; Masaomi Iyo; Norio Ozaki

doi:10.1016/j.pnpbp.2011.04.003

Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population

Tomoko Yoshimura, Hinako Usui, Nagahide Takahashi, Akira Yoshimi, Shinichi Saito, Branko Aleksic, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki

Psychiatry

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

Methamphetamine (MAP) dependence is a highly heritable and aberrant dopaminergic signaling that has been implicated in the disease. Glial cell line-derived neurotrophic factor (GDNF), which plays an important role in the survival of dopaminergic neurons, may be involved in this disorder. In this study, we examined the association between GDNF and MAP dependence using a Japanese population-based sample. We selected eight single nucleotide polymorphisms (SNPs) in the GDNF locus for the association analysis. When patients with MAP dependence were divided into two subgroups consisting of multi-substance and MAP-only users, we detected a significant association between these two groups and the tagging SNP, rs2910704 (after Bonferroni's correction; allele P = 0.034). Thus, GDNF is likely to be related to the severity of MAP use in the Japanese population.

Original language	English
Pages (from-to)	1268-1272
Number of pages	5
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	35
Issue number	5
DOIs	https://doi.org/10.1016/j.pnpbp.2011.04.003
Publication status	Published - 01-07-2011

All Science Journal Classification (ASJC) codes

Pharmacology
Biological Psychiatry

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Yoshimura, T., Usui, H., Takahashi, N., Yoshimi, A., Saito, S., Aleksic, B., Ujike, H., Inada, T., Yamada, M., Uchimura, N., Iwata, N., Sora, I., Iyo, M., & Ozaki, N. (2011). Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(5), 1268-1272. https://doi.org/10.1016/j.pnpbp.2011.04.003

Yoshimura, Tomoko ; Usui, Hinako ; Takahashi, Nagahide ; Yoshimi, Akira ; Saito, Shinichi ; Aleksic, Branko ; Ujike, Hiroshi ; Inada, Toshiya ; Yamada, Mitsuhiko ; Uchimura, Naohisa ; Iwata, Nakao ; Sora, Ichiro ; Iyo, Masaomi ; Ozaki, Norio. / Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2011 ; Vol. 35, No. 5. pp. 1268-1272.

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title = "Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population",

abstract = "Methamphetamine (MAP) dependence is a highly heritable and aberrant dopaminergic signaling that has been implicated in the disease. Glial cell line-derived neurotrophic factor (GDNF), which plays an important role in the survival of dopaminergic neurons, may be involved in this disorder. In this study, we examined the association between GDNF and MAP dependence using a Japanese population-based sample. We selected eight single nucleotide polymorphisms (SNPs) in the GDNF locus for the association analysis. When patients with MAP dependence were divided into two subgroups consisting of multi-substance and MAP-only users, we detected a significant association between these two groups and the tagging SNP, rs2910704 (after Bonferroni's correction; allele P = 0.034). Thus, GDNF is likely to be related to the severity of MAP use in the Japanese population.",

author = "Tomoko Yoshimura and Hinako Usui and Nagahide Takahashi and Akira Yoshimi and Shinichi Saito and Branko Aleksic and Hiroshi Ujike and Toshiya Inada and Mitsuhiko Yamada and Naohisa Uchimura and Nakao Iwata and Ichiro Sora and Masaomi Iyo and Norio Ozaki",

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Yoshimura, T, Usui, H, Takahashi, N, Yoshimi, A, Saito, S, Aleksic, B, Ujike, H, Inada, T, Yamada, M, Uchimura, N, Iwata, N, Sora, I, Iyo, M & Ozaki, N 2011, 'Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 35, no. 5, pp. 1268-1272. https://doi.org/10.1016/j.pnpbp.2011.04.003

Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population. / Yoshimura, Tomoko; Usui, Hinako; Takahashi, Nagahide; Yoshimi, Akira; Saito, Shinichi; Aleksic, Branko; Ujike, Hiroshi; Inada, Toshiya; Yamada, Mitsuhiko; Uchimura, Naohisa; Iwata, Nakao; Sora, Ichiro; Iyo, Masaomi; Ozaki, Norio.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 35, No. 5, 01.07.2011, p. 1268-1272.

Research output: Contribution to journal › Article

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T1 - Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population

AU - Yoshimura, Tomoko

AU - Usui, Hinako

AU - Takahashi, Nagahide

AU - Yoshimi, Akira

AU - Saito, Shinichi

AU - Aleksic, Branko

AU - Ujike, Hiroshi

AU - Inada, Toshiya

AU - Yamada, Mitsuhiko

AU - Uchimura, Naohisa

AU - Iwata, Nakao

AU - Sora, Ichiro

AU - Iyo, Masaomi

AU - Ozaki, Norio

PY - 2011/7/1

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AB - Methamphetamine (MAP) dependence is a highly heritable and aberrant dopaminergic signaling that has been implicated in the disease. Glial cell line-derived neurotrophic factor (GDNF), which plays an important role in the survival of dopaminergic neurons, may be involved in this disorder. In this study, we examined the association between GDNF and MAP dependence using a Japanese population-based sample. We selected eight single nucleotide polymorphisms (SNPs) in the GDNF locus for the association analysis. When patients with MAP dependence were divided into two subgroups consisting of multi-substance and MAP-only users, we detected a significant association between these two groups and the tagging SNP, rs2910704 (after Bonferroni's correction; allele P = 0.034). Thus, GDNF is likely to be related to the severity of MAP use in the Japanese population.

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