Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population

Tomoko Yoshimura, Hinako Usui, Nagahide Takahashi, Akira Yoshimi, Shinichi Saito, Branko Aleksic, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki

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Abstract

Methamphetamine (MAP) dependence is a highly heritable and aberrant dopaminergic signaling that has been implicated in the disease. Glial cell line-derived neurotrophic factor (GDNF), which plays an important role in the survival of dopaminergic neurons, may be involved in this disorder. In this study, we examined the association between GDNF and MAP dependence using a Japanese population-based sample. We selected eight single nucleotide polymorphisms (SNPs) in the GDNF locus for the association analysis. When patients with MAP dependence were divided into two subgroups consisting of multi-substance and MAP-only users, we detected a significant association between these two groups and the tagging SNP, rs2910704 (after Bonferroni's correction; allele P = 0.034). Thus, GDNF is likely to be related to the severity of MAP use in the Japanese population.

Original languageEnglish
Pages (from-to)1268-1272
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume35
Issue number5
DOIs
Publication statusPublished - 01-07-2011

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

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    Yoshimura, T., Usui, H., Takahashi, N., Yoshimi, A., Saito, S., Aleksic, B., Ujike, H., Inada, T., Yamada, M., Uchimura, N., Iwata, N., Sora, I., Iyo, M., & Ozaki, N. (2011). Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(5), 1268-1272. https://doi.org/10.1016/j.pnpbp.2011.04.003