TY - JOUR
T1 - Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population
AU - Yoshimura, Tomoko
AU - Usui, Hinako
AU - Takahashi, Nagahide
AU - Yoshimi, Akira
AU - Saito, Shinichi
AU - Aleksic, Branko
AU - Ujike, Hiroshi
AU - Inada, Toshiya
AU - Yamada, Mitsuhiko
AU - Uchimura, Naohisa
AU - Iwata, Nakao
AU - Sora, Ichiro
AU - Iyo, Masaomi
AU - Ozaki, Norio
N1 - Funding Information:
We thank the patients and healthy volunteers for their participation in our study. This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan , the Ministry of Health, Labor, and Welfare of Japan , a Grant-in-Aid for Scientific Research on Pathomechanisms of Brain Disorders from the Ministry of Education, Culture, Sports, Science and Technology of Japan, MEXT Academic Frontier , and the Core Research for Evolutional Science and Technology .
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Methamphetamine (MAP) dependence is a highly heritable and aberrant dopaminergic signaling that has been implicated in the disease. Glial cell line-derived neurotrophic factor (GDNF), which plays an important role in the survival of dopaminergic neurons, may be involved in this disorder. In this study, we examined the association between GDNF and MAP dependence using a Japanese population-based sample. We selected eight single nucleotide polymorphisms (SNPs) in the GDNF locus for the association analysis. When patients with MAP dependence were divided into two subgroups consisting of multi-substance and MAP-only users, we detected a significant association between these two groups and the tagging SNP, rs2910704 (after Bonferroni's correction; allele P = 0.034). Thus, GDNF is likely to be related to the severity of MAP use in the Japanese population.
AB - Methamphetamine (MAP) dependence is a highly heritable and aberrant dopaminergic signaling that has been implicated in the disease. Glial cell line-derived neurotrophic factor (GDNF), which plays an important role in the survival of dopaminergic neurons, may be involved in this disorder. In this study, we examined the association between GDNF and MAP dependence using a Japanese population-based sample. We selected eight single nucleotide polymorphisms (SNPs) in the GDNF locus for the association analysis. When patients with MAP dependence were divided into two subgroups consisting of multi-substance and MAP-only users, we detected a significant association between these two groups and the tagging SNP, rs2910704 (after Bonferroni's correction; allele P = 0.034). Thus, GDNF is likely to be related to the severity of MAP use in the Japanese population.
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U2 - 10.1016/j.pnpbp.2011.04.003
DO - 10.1016/j.pnpbp.2011.04.003
M3 - Article
C2 - 21514351
AN - SCOPUS:79957863625
VL - 35
SP - 1268
EP - 1272
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 5
ER -