Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis

Hideaki Kobayashi, Hiroshi Ujike, Nakao Iwata, Toshiya Inada, Mitsuhiko Yamada, Yoshimoto Sekine, Naohisa Uchimura, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Ichiro Sora

Research output: Contribution to journalArticle

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Abstract

There is a growing evidence that serotoninergic systems modulate dopaminergic neurotransmission. We analyzed the association between the variations in the brain tryptophan hydroxylase 2 (TPH2) gene, a rate limiting enzyme for serotonin biosynthesis, and methamphetamine (METH) dependence/psychosis in a Japanese population. We found ten single nucleotide polymorphisms (SNPs) and two polynucleotide polymorphisms in TPH2 gene exons and exon-intron boundaries. A total of 162 patients and 243 controls were used for the association analysis between these polymorphisms and METH dependence/psychosis. No significant differences were observed in either genotypic or allelic frequencies between METH dependent/psychotic patients and controls. A global test of differentiation among samples based on haplotype frequencies showed no significant association. With respect to latency of psychosis, prognosis of psychosis, and spontaneous relapse, we found no significant association with these SNPs. These results suggest that the TPH2 gene variants may not be a factor in vulnerability to METH dependence/psychosis.

Original languageEnglish
Pages (from-to)176-182
Number of pages7
JournalCurrent Neuropharmacology
Volume9
Issue number1
DOIs
Publication statusPublished - 30-03-2011

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Tryptophan Hydroxylase
Methamphetamine
Psychotic Disorders
Genes
Single Nucleotide Polymorphism
Exons
Polynucleotides
Synaptic Transmission
Introns
Haplotypes
Serotonin
Recurrence
Brain
Enzymes
Population

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Kobayashi, Hideaki ; Ujike, Hiroshi ; Iwata, Nakao ; Inada, Toshiya ; Yamada, Mitsuhiko ; Sekine, Yoshimoto ; Uchimura, Naohisa ; Iyo, Masaomi ; Ozaki, Norio ; Itokawa, Masanari ; Sora, Ichiro. / Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis. In: Current Neuropharmacology. 2011 ; Vol. 9, No. 1. pp. 176-182.
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Kobayashi, H, Ujike, H, Iwata, N, Inada, T, Yamada, M, Sekine, Y, Uchimura, N, Iyo, M, Ozaki, N, Itokawa, M & Sora, I 2011, 'Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis', Current Neuropharmacology, vol. 9, no. 1, pp. 176-182. https://doi.org/10.2174/157015911795017335

Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis. / Kobayashi, Hideaki; Ujike, Hiroshi; Iwata, Nakao; Inada, Toshiya; Yamada, Mitsuhiko; Sekine, Yoshimoto; Uchimura, Naohisa; Iyo, Masaomi; Ozaki, Norio; Itokawa, Masanari; Sora, Ichiro.

In: Current Neuropharmacology, Vol. 9, No. 1, 30.03.2011, p. 176-182.

Research output: Contribution to journalArticle

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