Association between 1,25-dihydroxyvitamin D and left atrial diameter in pre-dialysis chronic kidney disease patients

Daijo Inaguma, Hibiki Shinjo, Akihito Tanaka, Eri Ito, Naoki Kamegai, Akiko Kato, Minami Mizutani, Hiroya Shimogushi, Yasuhiro Otsuka, Asami Takeda, Midori Hasegawa, Yukio Yuzawa

Research output: Contribution to journalArticle

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Abstract

Objective: To investigate the correlation between serum 1,25-dihydroxyvitamin D (1,25D) levels and left atrial diameter (LAD) using echocardiography in pre-dialysis chronic kidney disease (CKD). Subjects and methods: From an initial population of 487 patients (109 met the exclusion criteria), a total of 378 patients with CKD stage 3a-5 who had not undergone dialysis or kidney transplantation were included in the study. The relationship between serum 1,25D levels and LAD was examined. Moreover, factors that impacted LAD were extracted through stepwise multiple regression analyses. Results: Serum 1,25D levels correlated negatively with LAD, left ventricular end-diastolic diameter, interventricular septum thickness, end-diastolic volume, stroke volume, left ventricular mass index (LVMI), and E/e'. Stepwise multiple regression analyses revealed there was a significant relationship between serum 1,25D levels and LAD (regression coefficient =-0.070, p = 0.001). In the stratified analysis, serum 1,25D levels were associated with LAD in the LVMI < 125 g/m2 (regression coefficient =-0.067, p = 0.038) and ejection fraction (EF) ≥ 60% groups (regression coefficient =-0.080, p = 0.004). Conclusion: Serum 1,25D levels were independently associated with LAD in CKD patients; however, the association was not significant in patients with an EF < 60% and LVMI > 125 g/m2.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalClinical Nephrology
Volume86
Issue number5
DOIs
Publication statusPublished - 01-01-2016

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Chronic Renal Insufficiency
Dialysis
Serum
Regression Analysis
Stroke Volume
Kidney Transplantation
Echocardiography
1,25-dihydroxyvitamin D
Population

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Inaguma, Daijo ; Shinjo, Hibiki ; Tanaka, Akihito ; Ito, Eri ; Kamegai, Naoki ; Kato, Akiko ; Mizutani, Minami ; Shimogushi, Hiroya ; Otsuka, Yasuhiro ; Takeda, Asami ; Hasegawa, Midori ; Yuzawa, Yukio. / Association between 1,25-dihydroxyvitamin D and left atrial diameter in pre-dialysis chronic kidney disease patients. In: Clinical Nephrology. 2016 ; Vol. 86, No. 5. pp. 229-235.
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abstract = "Objective: To investigate the correlation between serum 1,25-dihydroxyvitamin D (1,25D) levels and left atrial diameter (LAD) using echocardiography in pre-dialysis chronic kidney disease (CKD). Subjects and methods: From an initial population of 487 patients (109 met the exclusion criteria), a total of 378 patients with CKD stage 3a-5 who had not undergone dialysis or kidney transplantation were included in the study. The relationship between serum 1,25D levels and LAD was examined. Moreover, factors that impacted LAD were extracted through stepwise multiple regression analyses. Results: Serum 1,25D levels correlated negatively with LAD, left ventricular end-diastolic diameter, interventricular septum thickness, end-diastolic volume, stroke volume, left ventricular mass index (LVMI), and E/e'. Stepwise multiple regression analyses revealed there was a significant relationship between serum 1,25D levels and LAD (regression coefficient =-0.070, p = 0.001). In the stratified analysis, serum 1,25D levels were associated with LAD in the LVMI < 125 g/m2 (regression coefficient =-0.067, p = 0.038) and ejection fraction (EF) ≥ 60{\%} groups (regression coefficient =-0.080, p = 0.004). Conclusion: Serum 1,25D levels were independently associated with LAD in CKD patients; however, the association was not significant in patients with an EF < 60{\%} and LVMI > 125 g/m2.",
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Inaguma, D, Shinjo, H, Tanaka, A, Ito, E, Kamegai, N, Kato, A, Mizutani, M, Shimogushi, H, Otsuka, Y, Takeda, A, Hasegawa, M & Yuzawa, Y 2016, 'Association between 1,25-dihydroxyvitamin D and left atrial diameter in pre-dialysis chronic kidney disease patients', Clinical Nephrology, vol. 86, no. 5, pp. 229-235. https://doi.org/10.5414/CN108794

Association between 1,25-dihydroxyvitamin D and left atrial diameter in pre-dialysis chronic kidney disease patients. / Inaguma, Daijo; Shinjo, Hibiki; Tanaka, Akihito; Ito, Eri; Kamegai, Naoki; Kato, Akiko; Mizutani, Minami; Shimogushi, Hiroya; Otsuka, Yasuhiro; Takeda, Asami; Hasegawa, Midori; Yuzawa, Yukio.

In: Clinical Nephrology, Vol. 86, No. 5, 01.01.2016, p. 229-235.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between 1,25-dihydroxyvitamin D and left atrial diameter in pre-dialysis chronic kidney disease patients

AU - Inaguma, Daijo

AU - Shinjo, Hibiki

AU - Tanaka, Akihito

AU - Ito, Eri

AU - Kamegai, Naoki

AU - Kato, Akiko

AU - Mizutani, Minami

AU - Shimogushi, Hiroya

AU - Otsuka, Yasuhiro

AU - Takeda, Asami

AU - Hasegawa, Midori

AU - Yuzawa, Yukio

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Objective: To investigate the correlation between serum 1,25-dihydroxyvitamin D (1,25D) levels and left atrial diameter (LAD) using echocardiography in pre-dialysis chronic kidney disease (CKD). Subjects and methods: From an initial population of 487 patients (109 met the exclusion criteria), a total of 378 patients with CKD stage 3a-5 who had not undergone dialysis or kidney transplantation were included in the study. The relationship between serum 1,25D levels and LAD was examined. Moreover, factors that impacted LAD were extracted through stepwise multiple regression analyses. Results: Serum 1,25D levels correlated negatively with LAD, left ventricular end-diastolic diameter, interventricular septum thickness, end-diastolic volume, stroke volume, left ventricular mass index (LVMI), and E/e'. Stepwise multiple regression analyses revealed there was a significant relationship between serum 1,25D levels and LAD (regression coefficient =-0.070, p = 0.001). In the stratified analysis, serum 1,25D levels were associated with LAD in the LVMI < 125 g/m2 (regression coefficient =-0.067, p = 0.038) and ejection fraction (EF) ≥ 60% groups (regression coefficient =-0.080, p = 0.004). Conclusion: Serum 1,25D levels were independently associated with LAD in CKD patients; however, the association was not significant in patients with an EF < 60% and LVMI > 125 g/m2.

AB - Objective: To investigate the correlation between serum 1,25-dihydroxyvitamin D (1,25D) levels and left atrial diameter (LAD) using echocardiography in pre-dialysis chronic kidney disease (CKD). Subjects and methods: From an initial population of 487 patients (109 met the exclusion criteria), a total of 378 patients with CKD stage 3a-5 who had not undergone dialysis or kidney transplantation were included in the study. The relationship between serum 1,25D levels and LAD was examined. Moreover, factors that impacted LAD were extracted through stepwise multiple regression analyses. Results: Serum 1,25D levels correlated negatively with LAD, left ventricular end-diastolic diameter, interventricular septum thickness, end-diastolic volume, stroke volume, left ventricular mass index (LVMI), and E/e'. Stepwise multiple regression analyses revealed there was a significant relationship between serum 1,25D levels and LAD (regression coefficient =-0.070, p = 0.001). In the stratified analysis, serum 1,25D levels were associated with LAD in the LVMI < 125 g/m2 (regression coefficient =-0.067, p = 0.038) and ejection fraction (EF) ≥ 60% groups (regression coefficient =-0.080, p = 0.004). Conclusion: Serum 1,25D levels were independently associated with LAD in CKD patients; however, the association was not significant in patients with an EF < 60% and LVMI > 125 g/m2.

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