Association between 24h urinary sodium and potassium excretion and estimated Glomerular Filtration Rate (eGFR) decline or death in patients with diabetes mellitus and eGFR more than 30 ml/min/1.73m2

Takanobu Nagata, Hiroshi Sobajima, Norimi Ohashi, Akihiro Hirakawa, Takayuki Katsuno, Yoshinari Yasuda, Seiichi Matsuo, Naotake Tsuboi, Shoichi Maruyama

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background: Data regarding the association between 24h urinary sodium and potassium excretion with kidney outcomes in patients with diabetes mellitus is currently scarce. Methods: We conducted a single-center, retrospective cohort study in which 1230 patients with diabetes who had undergone a 24h urinary sodium and potassium excretion test were analyzed. Patients with incomplete urine collection were excluded based on 24h urinary creatinine excretion. Outcomes were the composite of a 30% decline in eGFR or death. Multivariate cox regression analysis was used to investigate the association between urinary sodium and potassium excretion and outcomes. Results: With a mean follow up period of 5.47 years, 130 patients reached the outcomes (30% decline in eGFR: 124, death: 6). Mean (SD) eGFR and 24h urinary sodium and potassium excretion at baseline were 78.6 (19.5) ml/min/1.73m2, 4.50 (1.64) g/day, and 2.14 (0.77) g/day. Compared with sodium excretion < 3.0 g/day, no significant change in risk of outcomes was observed with increased increments of 1.0 g/day. Compared with potassium excretion of < 1.5 g/day, 2.0-2.5 g/day, and 2.5-3.0 g/day were significantly associated with a lower risk of outcomes (hazard ratio [HR], 0.49 and 0.44; 95% confidence interval [CI], 0.28 to 0.84 and 0.22 to 0.87). Conclusions: 24h urinary sodium excretion was not significantly associated with a risk of 30% decline in eGFR or death in patients with diabetes. However, an increased risk of 30% decline in eGFR or death was significantly associated with 24h urinary potassium excretion < 1.5 g/day than with 2.0-2.5 g/day and 2.5-3.0 g/day.

Original languageEnglish
Article numbere0152306
JournalPloS one
Volume11
Issue number5
DOIs
Publication statusPublished - 01-05-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'Association between 24h urinary sodium and potassium excretion and estimated Glomerular Filtration Rate (eGFR) decline or death in patients with diabetes mellitus and eGFR more than 30 ml/min/1.73m<sup>2</sup>'. Together they form a unique fingerprint.

Cite this