Association between 5HT1b receptor gene and methamphetamine dependence

H. Ujike, M. Kishimoto, Y. Okahisa, M. Kodama, M. Takaki, T. Inada, N. Uchimura, M. Yamada, Nakao Iwata, M. Iyo, I. Sora, N. Ozaki

Research output: Contribution to journalArticle

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Abstract

Several lines of evidence implicate serotonergic dysfunction in diverse psychiatric disorders including anxiety, depression, and drug abuse. Mice with a knock-out of the 5HT1b receptor gene (HTR1B) displayed increased locomotor response to cocaine and elevated motivation to self-administer cocaine and alcohol. Previous genetic studies showed significant associations of HTR1B with alcohol dependence and substance abuse, but were followed by inconsistent results. We examined a case-control genetic association study of HTR1B with methamphetamine-dependence patients in a Japanese population. The subjects were 231 patients with methamphetamine dependence, 214 of whom had a comorbidity of methamphetamine psychosis, and 248 age- and sex-matched healthy controls. The three single nucleotide polymorphisms (SNPs), rs130058 (A-165T), rs1228814 (A-700C) and rs1228814 (A+1180G) of HTR1B were genotyped. There was no significant difference in allelic and genotypic distributions of the SNPs between methamphetamine dependence and the control. Genetic associations of HTR1B were tested with several clinical phenotypes of methamphetamine dependence and/or psychosis, such as age at first abuse, duration of latency from the first abuse to onset of psychosis, prognosis of psychosis after therapy, and complication of spontaneous relapse of psychotic state. There was, however, no asscocation between any SNP and the clinical phenotypes. Haplotype analyses showed the three SNPs examined were within linkage disequilibrium, which implied that the three SNPs covered the whole HTR1B, and distribution of estimated haplotype frequency was not different between the groups. The present findings may indicate that HTR1B does not play a major role in individual susceptibility to methamphetamine dependence or development of methamphetamine-induced psychosis.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalCurrent Neuropharmacology
Volume9
Issue number1
DOIs
Publication statusPublished - 30-03-2011

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Methamphetamine
Psychotic Disorders
Single Nucleotide Polymorphism
Genes
Cocaine
Haplotypes
Alcoholism
Substance-Related Disorders
Phenotype
Linkage Disequilibrium
Genetic Association Studies
Anxiety Disorders
Psychiatry
Comorbidity
Motivation
Alcohols
Depression
Recurrence
Population

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Ujike, H., Kishimoto, M., Okahisa, Y., Kodama, M., Takaki, M., Inada, T., ... Ozaki, N. (2011). Association between 5HT1b receptor gene and methamphetamine dependence. Current Neuropharmacology, 9(1), 163-168. https://doi.org/10.2174/157015911795017137
Ujike, H. ; Kishimoto, M. ; Okahisa, Y. ; Kodama, M. ; Takaki, M. ; Inada, T. ; Uchimura, N. ; Yamada, M. ; Iwata, Nakao ; Iyo, M. ; Sora, I. ; Ozaki, N. / Association between 5HT1b receptor gene and methamphetamine dependence. In: Current Neuropharmacology. 2011 ; Vol. 9, No. 1. pp. 163-168.
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Ujike, H, Kishimoto, M, Okahisa, Y, Kodama, M, Takaki, M, Inada, T, Uchimura, N, Yamada, M, Iwata, N, Iyo, M, Sora, I & Ozaki, N 2011, 'Association between 5HT1b receptor gene and methamphetamine dependence', Current Neuropharmacology, vol. 9, no. 1, pp. 163-168. https://doi.org/10.2174/157015911795017137

Association between 5HT1b receptor gene and methamphetamine dependence. / Ujike, H.; Kishimoto, M.; Okahisa, Y.; Kodama, M.; Takaki, M.; Inada, T.; Uchimura, N.; Yamada, M.; Iwata, Nakao; Iyo, M.; Sora, I.; Ozaki, N.

In: Current Neuropharmacology, Vol. 9, No. 1, 30.03.2011, p. 163-168.

Research output: Contribution to journalArticle

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T1 - Association between 5HT1b receptor gene and methamphetamine dependence

AU - Ujike, H.

AU - Kishimoto, M.

AU - Okahisa, Y.

AU - Kodama, M.

AU - Takaki, M.

AU - Inada, T.

AU - Uchimura, N.

AU - Yamada, M.

AU - Iwata, Nakao

AU - Iyo, M.

AU - Sora, I.

AU - Ozaki, N.

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N2 - Several lines of evidence implicate serotonergic dysfunction in diverse psychiatric disorders including anxiety, depression, and drug abuse. Mice with a knock-out of the 5HT1b receptor gene (HTR1B) displayed increased locomotor response to cocaine and elevated motivation to self-administer cocaine and alcohol. Previous genetic studies showed significant associations of HTR1B with alcohol dependence and substance abuse, but were followed by inconsistent results. We examined a case-control genetic association study of HTR1B with methamphetamine-dependence patients in a Japanese population. The subjects were 231 patients with methamphetamine dependence, 214 of whom had a comorbidity of methamphetamine psychosis, and 248 age- and sex-matched healthy controls. The three single nucleotide polymorphisms (SNPs), rs130058 (A-165T), rs1228814 (A-700C) and rs1228814 (A+1180G) of HTR1B were genotyped. There was no significant difference in allelic and genotypic distributions of the SNPs between methamphetamine dependence and the control. Genetic associations of HTR1B were tested with several clinical phenotypes of methamphetamine dependence and/or psychosis, such as age at first abuse, duration of latency from the first abuse to onset of psychosis, prognosis of psychosis after therapy, and complication of spontaneous relapse of psychotic state. There was, however, no asscocation between any SNP and the clinical phenotypes. Haplotype analyses showed the three SNPs examined were within linkage disequilibrium, which implied that the three SNPs covered the whole HTR1B, and distribution of estimated haplotype frequency was not different between the groups. The present findings may indicate that HTR1B does not play a major role in individual susceptibility to methamphetamine dependence or development of methamphetamine-induced psychosis.

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Ujike H, Kishimoto M, Okahisa Y, Kodama M, Takaki M, Inada T et al. Association between 5HT1b receptor gene and methamphetamine dependence. Current Neuropharmacology. 2011 Mar 30;9(1):163-168. https://doi.org/10.2174/157015911795017137