Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [11C]PBB3-PET study

Hitoshi Shimada; Soichiro Kitamura; Hitoshi Shinotoh; Hironobu Endo; Fumitoshi Niwa; Shigeki Hirano; Yasuyuki Kimura; Ming Rong Zhang; Satoshi Kuwabara; Tetsuya Suhara; Makoto Higuchi

doi:10.1016/j.dadm.2016.12.009

Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3-PET study

Hitoshi Shimada, Soichiro Kitamura, Hitoshi Shinotoh, Hironobu Endo, Fumitoshi Niwa, Shigeki Hirano, Yasuyuki Kimura, Ming Rong Zhang, Satoshi Kuwabara, Tetsuya Suhara, Makoto Higuchi

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

Introduction Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear. Methods Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [¹¹C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [¹¹C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(−)-cognitive healthy controls (HCs). Results High tau burden was associated with aging and low-level education in PiB(−)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(−)-HC. Discussion The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.

Original language	English
Pages (from-to)	11-20
Number of pages	10
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	6
DOIs	https://doi.org/10.1016/j.dadm.2016.12.009
Publication status	Published - 2017
Externally published	Yes

All Science Journal Classification (ASJC) codes

Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.dadm.2016.12.009

Cite this

Shimada, H., Kitamura, S., Shinotoh, H., Endo, H., Niwa, F., Hirano, S., Kimura, Y., Zhang, M. R., Kuwabara, S., Suhara, T., & Higuchi, M. (2017). Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3-PET study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 6, 11-20. https://doi.org/10.1016/j.dadm.2016.12.009

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title = "Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [11C]PBB3-PET study",

abstract = "Introduction Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear. Methods Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(−)-cognitive healthy controls (HCs). Results High tau burden was associated with aging and low-level education in PiB(−)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(−)-HC. Discussion The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.",

author = "Hitoshi Shimada and Soichiro Kitamura and Hitoshi Shinotoh and Hironobu Endo and Fumitoshi Niwa and Shigeki Hirano and Yasuyuki Kimura and Zhang, {Ming Rong} and Satoshi Kuwabara and Tetsuya Suhara and Makoto Higuchi",

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year = "2017",

doi = "10.1016/j.dadm.2016.12.009",

language = "English",

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Shimada, H, Kitamura, S, Shinotoh, H, Endo, H, Niwa, F, Hirano, S, Kimura, Y, Zhang, MR, Kuwabara, S, Suhara, T & Higuchi, M 2017, 'Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3-PET study', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 6, pp. 11-20. https://doi.org/10.1016/j.dadm.2016.12.009

Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3-PET study. / Shimada, Hitoshi; Kitamura, Soichiro; Shinotoh, Hitoshi et al.
In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 6, 2017, p. 11-20.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains

T2 - A [11C]PBB3-PET study

AU - Shimada, Hitoshi

AU - Kitamura, Soichiro

AU - Shinotoh, Hitoshi

AU - Endo, Hironobu

AU - Niwa, Fumitoshi

AU - Hirano, Shigeki

AU - Kimura, Yasuyuki

AU - Zhang, Ming Rong

AU - Kuwabara, Satoshi

AU - Suhara, Tetsuya

AU - Higuchi, Makoto

PY - 2017

Y1 - 2017

N2 - Introduction Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear. Methods Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(−)-cognitive healthy controls (HCs). Results High tau burden was associated with aging and low-level education in PiB(−)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(−)-HC. Discussion The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.

AB - Introduction Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear. Methods Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(−)-cognitive healthy controls (HCs). Results High tau burden was associated with aging and low-level education in PiB(−)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(−)-HC. Discussion The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.

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