Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [11C]PBB3-PET study

Hitoshi Shimada; Soichiro Kitamura; Hitoshi Shinotoh; Hironobu Endo; Fumitoshi Niwa; Shigeki Hirano; Yasuyuki Kimura; Ming Rong Zhang; Satoshi Kuwabara; Tetsuya Suhara; Makoto Higuchi

doi:10.1016/j.dadm.2016.12.009

Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3-PET study

Hitoshi Shimada
, Soichiro Kitamura
, Hitoshi Shinotoh
, Hironobu Endo
, Fumitoshi Niwa
, Shigeki Hirano
, Yasuyuki Kimura
, Ming Rong Zhang
, Satoshi Kuwabara
, Tetsuya Suhara
, Makoto Higuchi

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

Introduction Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear. Methods Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [¹¹C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [¹¹C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(−)-cognitive healthy controls (HCs). Results High tau burden was associated with aging and low-level education in PiB(−)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(−)-HC. Discussion The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.

Original language	English
Pages (from-to)	11-20
Number of pages	10
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	6
DOIs	https://doi.org/10.1016/j.dadm.2016.12.009
Publication status	Published - 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Clinical Neurology
Psychiatry and Mental health

Access to Document

10.1016/j.dadm.2016.12.009

Cite this

Shimada, H., Kitamura, S., Shinotoh, H., Endo, H., Niwa, F., Hirano, S., Kimura, Y., Zhang, M. R., Kuwabara, S., Suhara, T., & Higuchi, M. (2017). Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3-PET study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 6, 11-20. https://doi.org/10.1016/j.dadm.2016.12.009

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title = "Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [11C]PBB3-PET study",

abstract = "Introduction Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear. Methods Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(−)-cognitive healthy controls (HCs). Results High tau burden was associated with aging and low-level education in PiB(−)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(−)-HC. Discussion The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.",

author = "Hitoshi Shimada and Soichiro Kitamura and Hitoshi Shinotoh and Hironobu Endo and Fumitoshi Niwa and Shigeki Hirano and Yasuyuki Kimura and Zhang, \{Ming Rong\} and Satoshi Kuwabara and Tetsuya Suhara and Makoto Higuchi",

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year = "2017",

doi = "10.1016/j.dadm.2016.12.009",

language = "English",

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Shimada, H, Kitamura, S, Shinotoh, H, Endo, H, Niwa, F, Hirano, S, Kimura, Y, Zhang, MR, Kuwabara, S, Suhara, T & Higuchi, M 2017, 'Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3-PET study', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 6, pp. 11-20. https://doi.org/10.1016/j.dadm.2016.12.009

Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3-PET study. / Shimada, Hitoshi; Kitamura, Soichiro; Shinotoh, Hitoshi et al.
In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 6, 2017, p. 11-20.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains

T2 - A [11C]PBB3-PET study

AU - Shimada, Hitoshi

AU - Kitamura, Soichiro

AU - Shinotoh, Hitoshi

AU - Endo, Hironobu

AU - Niwa, Fumitoshi

AU - Hirano, Shigeki

AU - Kimura, Yasuyuki

AU - Zhang, Ming Rong

AU - Kuwabara, Satoshi

AU - Suhara, Tetsuya

AU - Higuchi, Makoto

PY - 2017

Y1 - 2017

N2 - Introduction Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear. Methods Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(−)-cognitive healthy controls (HCs). Results High tau burden was associated with aging and low-level education in PiB(−)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(−)-HC. Discussion The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.

AB - Introduction Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear. Methods Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(−)-cognitive healthy controls (HCs). Results High tau burden was associated with aging and low-level education in PiB(−)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(−)-HC. Discussion The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.

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DO - 10.1016/j.dadm.2016.12.009

M3 - Article

AN - SCOPUS:85009837024

SN - 2352-8729

VL - 6

SP - 11

EP - 20

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

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