TY - JOUR
T1 - Association between an 8q24 locus and the risk of colorectal cancer in Japanese
AU - Matsuo, Keitaro
AU - Suzuki, Takeshi
AU - Ito, Hidemi
AU - Hosono, Satoyo
AU - Kawase, Takakazu
AU - Watanabe, Miki
AU - Shitara, Kohei
AU - Komori, Koji
AU - Kanemitsu, Yukihide
AU - Hirai, Takashi
AU - Yatabe, Yasushi
AU - Tanaka, Hideo
AU - Tajima, Kazuo
N1 - Funding Information:
This study was supported by a Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, Culture and Technology of Japan, for Cancer Research from the Ministry of Health, Labour and Welfare of Japan, and for the Third Term Comprehensive 10-year Strategy for Cancer Control from the Ministry of Health, Labour and Welfare of Japan.
PY - 2009/10/26
Y1 - 2009/10/26
N2 - Background: A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited. Methods: We conducted a case-control study in 481 patients with colorectal cancer (CRC) and 962 sex-age matched non-cancer controls. Data on lifestyle factors, including diet, were obtained by self-administered questionnaire. Two 8q24 loci, rs6983267 and rs10090154, were assessed by the TaqMan method. Associations were then assessed by multivariate logistic regression models that considered potential confounders. Results: We found an increased risk of CRC with rs6983267 but not with rs10090154. An allelic OR was 1.22 (1.04-1.44, p for trend = 0.014), which remained significant after adjustment for confounders (OR = 1.25). No statistically significant interaction with potential confounding factors was observed. Conclusion: The polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted.
AB - Background: A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited. Methods: We conducted a case-control study in 481 patients with colorectal cancer (CRC) and 962 sex-age matched non-cancer controls. Data on lifestyle factors, including diet, were obtained by self-administered questionnaire. Two 8q24 loci, rs6983267 and rs10090154, were assessed by the TaqMan method. Associations were then assessed by multivariate logistic regression models that considered potential confounders. Results: We found an increased risk of CRC with rs6983267 but not with rs10090154. An allelic OR was 1.22 (1.04-1.44, p for trend = 0.014), which remained significant after adjustment for confounders (OR = 1.25). No statistically significant interaction with potential confounding factors was observed. Conclusion: The polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted.
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U2 - 10.1186/1471-2407-9-379
DO - 10.1186/1471-2407-9-379
M3 - Article
C2 - 19857256
AN - SCOPUS:71049186073
SN - 1471-2407
VL - 9
JO - BMC Cancer
JF - BMC Cancer
M1 - 379
ER -
