TY - JOUR
T1 - Association between body weight at weaning and remodeling in the subcutaneous adipose tissue of obese adult mice with undernourishment in utero
AU - Kohmura, Yukiko Kobayashi
AU - Kanayama, Naohiro
AU - Muramatsu, Keiko
AU - Tamura, Naoaki
AU - Yaguchi, Chizuko
AU - Uchida, Toshiyuki
AU - Suzuki, Kazunao
AU - Sugihara, Kazuhiro
AU - Aoe, Seiichiro
AU - Sasaki, Takeshi
AU - Suganami, Takayoshi
AU - Ogawa, Yoshihiro
AU - Itoh, Hiroaki
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: in part by Grants-in-aid for Scientific Research from the Ministry of Education, Science, Culture and Sports, Japan (No. 24390273 and No. 23659534 ) and grants from Kanzawa Medical Research Foundation , Society for Women's Health Science Research, The Food Science Institute Foundation, and Hamamatsu Foundation for Science and Technology Promotion.
PY - 2013/7
Y1 - 2013/7
N2 - Rapid growth in infancy considerably increases the risk of obesity and metabolic disorders in adulthood especially among neonates born small. To investigate the mechanism involved, we developed an animal model of undernourishment in utero by maternal caloric restriction, in which the Z scores of body weight at weaning (19.5 days) positively correlated with parameters of obesity, metabolic disorders, and remodeling of subcutaneous adipose tissue, such as numbers of macrophages in adipose tissue, the ratio of inflammatory M1 to anti-inflammatory M2 macrophages, estimated by gene expression of specific antigens, and the relative ratio of small adipocytes less than 30 μm in diameter, on a high-fat diet at 17 weeks of age. To our knowledge, this is the first report of a possible connection between infantile body weight and adipose tissue remodeling in obesity after undernourishment in utero.
AB - Rapid growth in infancy considerably increases the risk of obesity and metabolic disorders in adulthood especially among neonates born small. To investigate the mechanism involved, we developed an animal model of undernourishment in utero by maternal caloric restriction, in which the Z scores of body weight at weaning (19.5 days) positively correlated with parameters of obesity, metabolic disorders, and remodeling of subcutaneous adipose tissue, such as numbers of macrophages in adipose tissue, the ratio of inflammatory M1 to anti-inflammatory M2 macrophages, estimated by gene expression of specific antigens, and the relative ratio of small adipocytes less than 30 μm in diameter, on a high-fat diet at 17 weeks of age. To our knowledge, this is the first report of a possible connection between infantile body weight and adipose tissue remodeling in obesity after undernourishment in utero.
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U2 - 10.1177/1933719112466300
DO - 10.1177/1933719112466300
M3 - Article
C2 - 23296035
AN - SCOPUS:84878851445
SN - 1933-7191
VL - 20
SP - 813
EP - 827
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 7
ER -