Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study

Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group

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8 Citations (Scopus)

Abstract

Aims: Brain-muscle-Arnt-like protein-1 (BMAL1) and BMAL2 genes are essential components of the circadian clock, and are considered to be involved in glucose homeostasis. We examined whether single nucleotide polymorphisms (SNPs) of BMAL1 and BMAL2 were associated with the prevalence of type 2 diabetes (T2DM) in the general Japanese population. Methods: We studied 2467 subjects (1232 men and 1235 women, 35-69 years old), including 105 men and 57 women with T2DM, from the participants of the Japan Multi-institutional Collaborative Cohort Study. The association between SNPs in the BMAL1 (rs11022775 and rs2290035) and BMAL2 (rs7958822) genes and T2DM were analyzed by multiple logistic regression after adjustment for potential confounders. Analysis was also performed after stratification by body mass index (≥25kg/m2 and <25kg/m2) to investigate an interaction between genotypes and obesity. Results: The A/G and A/A genotypes of BMAL2 rs7958822 showed significantly higher adjusted odds ratios (OR) for T2DM than the G/G genotype among obese men (OR = 2.2, 95% confidence intervals [CI] 1.1, 4.6, P for interaction = 0.0495) and obese women (OR = 2.7, 95% CI 1.1, 6.7, P for interaction = 0.199). There were no significant associations between BMAL1 rs11022775 or rs2290035 genotypes and T2DM. Conclusions: To the best of our knowledge, this is the first study to show the significant association between BMAL2 rs7958822 genotype and T2DM among obese subjects.

Original languageEnglish
Pages (from-to)301-308
Number of pages8
JournalDiabetes Research and Clinical Practice
Volume110
Issue number3
DOIs
Publication statusPublished - 01-12-2015

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ARNTL Transcription Factors
Type 2 Diabetes Mellitus
Japan
Cohort Studies
Cross-Sectional Studies
Genotype
Muscles
Genes
Odds Ratio
Brain
Single Nucleotide Polymorphism
Proteins
Confidence Intervals
Gene Components
Circadian Clocks
Body Mass Index
Homeostasis
Obesity
Logistic Models
Glucose

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

@article{5dc59f43f91e4090830aaace6de4ed4d,
title = "Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study",
abstract = "Aims: Brain-muscle-Arnt-like protein-1 (BMAL1) and BMAL2 genes are essential components of the circadian clock, and are considered to be involved in glucose homeostasis. We examined whether single nucleotide polymorphisms (SNPs) of BMAL1 and BMAL2 were associated with the prevalence of type 2 diabetes (T2DM) in the general Japanese population. Methods: We studied 2467 subjects (1232 men and 1235 women, 35-69 years old), including 105 men and 57 women with T2DM, from the participants of the Japan Multi-institutional Collaborative Cohort Study. The association between SNPs in the BMAL1 (rs11022775 and rs2290035) and BMAL2 (rs7958822) genes and T2DM were analyzed by multiple logistic regression after adjustment for potential confounders. Analysis was also performed after stratification by body mass index (≥25kg/m2 and <25kg/m2) to investigate an interaction between genotypes and obesity. Results: The A/G and A/A genotypes of BMAL2 rs7958822 showed significantly higher adjusted odds ratios (OR) for T2DM than the G/G genotype among obese men (OR = 2.2, 95{\%} confidence intervals [CI] 1.1, 4.6, P for interaction = 0.0495) and obese women (OR = 2.7, 95{\%} CI 1.1, 6.7, P for interaction = 0.199). There were no significant associations between BMAL1 rs11022775 or rs2290035 genotypes and T2DM. Conclusions: To the best of our knowledge, this is the first study to show the significant association between BMAL2 rs7958822 genotype and T2DM among obese subjects.",
author = "{Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group} and Miwa Yamaguchi and Hirokazu Uemura and Kokichi Arisawa and Sakurako Katsuura-Kamano and Nobuyuki Hamajima and Asahi Hishida and Shino Suma and Isao Oze and Kazuyo Nakamura and Naoyuki Takashima and Sadao Suzuki and Rie Ibusuki and Haruo Mikami and Keizo Ohnaka and Nagato Kuriyama and Michiaki Kubo and Michiaki Kubo",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.diabres.2015.10.009",
language = "English",
volume = "110",
pages = "301--308",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals

T2 - A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study

AU - Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group

AU - Yamaguchi, Miwa

AU - Uemura, Hirokazu

AU - Arisawa, Kokichi

AU - Katsuura-Kamano, Sakurako

AU - Hamajima, Nobuyuki

AU - Hishida, Asahi

AU - Suma, Shino

AU - Oze, Isao

AU - Nakamura, Kazuyo

AU - Takashima, Naoyuki

AU - Suzuki, Sadao

AU - Ibusuki, Rie

AU - Mikami, Haruo

AU - Ohnaka, Keizo

AU - Kuriyama, Nagato

AU - Kubo, Michiaki

AU - Kubo, Michiaki

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Aims: Brain-muscle-Arnt-like protein-1 (BMAL1) and BMAL2 genes are essential components of the circadian clock, and are considered to be involved in glucose homeostasis. We examined whether single nucleotide polymorphisms (SNPs) of BMAL1 and BMAL2 were associated with the prevalence of type 2 diabetes (T2DM) in the general Japanese population. Methods: We studied 2467 subjects (1232 men and 1235 women, 35-69 years old), including 105 men and 57 women with T2DM, from the participants of the Japan Multi-institutional Collaborative Cohort Study. The association between SNPs in the BMAL1 (rs11022775 and rs2290035) and BMAL2 (rs7958822) genes and T2DM were analyzed by multiple logistic regression after adjustment for potential confounders. Analysis was also performed after stratification by body mass index (≥25kg/m2 and <25kg/m2) to investigate an interaction between genotypes and obesity. Results: The A/G and A/A genotypes of BMAL2 rs7958822 showed significantly higher adjusted odds ratios (OR) for T2DM than the G/G genotype among obese men (OR = 2.2, 95% confidence intervals [CI] 1.1, 4.6, P for interaction = 0.0495) and obese women (OR = 2.7, 95% CI 1.1, 6.7, P for interaction = 0.199). There were no significant associations between BMAL1 rs11022775 or rs2290035 genotypes and T2DM. Conclusions: To the best of our knowledge, this is the first study to show the significant association between BMAL2 rs7958822 genotype and T2DM among obese subjects.

AB - Aims: Brain-muscle-Arnt-like protein-1 (BMAL1) and BMAL2 genes are essential components of the circadian clock, and are considered to be involved in glucose homeostasis. We examined whether single nucleotide polymorphisms (SNPs) of BMAL1 and BMAL2 were associated with the prevalence of type 2 diabetes (T2DM) in the general Japanese population. Methods: We studied 2467 subjects (1232 men and 1235 women, 35-69 years old), including 105 men and 57 women with T2DM, from the participants of the Japan Multi-institutional Collaborative Cohort Study. The association between SNPs in the BMAL1 (rs11022775 and rs2290035) and BMAL2 (rs7958822) genes and T2DM were analyzed by multiple logistic regression after adjustment for potential confounders. Analysis was also performed after stratification by body mass index (≥25kg/m2 and <25kg/m2) to investigate an interaction between genotypes and obesity. Results: The A/G and A/A genotypes of BMAL2 rs7958822 showed significantly higher adjusted odds ratios (OR) for T2DM than the G/G genotype among obese men (OR = 2.2, 95% confidence intervals [CI] 1.1, 4.6, P for interaction = 0.0495) and obese women (OR = 2.7, 95% CI 1.1, 6.7, P for interaction = 0.199). There were no significant associations between BMAL1 rs11022775 or rs2290035 genotypes and T2DM. Conclusions: To the best of our knowledge, this is the first study to show the significant association between BMAL2 rs7958822 genotype and T2DM among obese subjects.

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U2 - 10.1016/j.diabres.2015.10.009

DO - 10.1016/j.diabres.2015.10.009

M3 - Article

C2 - 26497775

AN - SCOPUS:84955216463

VL - 110

SP - 301

EP - 308

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

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