Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population

Nagahide Takahashi, Ryoko Ishihara, Shinichi Saito, Nobuhisa Maemo, Nagisa Aoyama, Xiofei Ji, Hideki Miura, Masashi Ikeda, Nakao Iwata, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Norio Ozaki, Toshiya Inada

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p = 0.0269), and with a 2 marker haplotype (p = 0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalSchizophrenia Research
Volume83
Issue number2-3
DOIs
Publication statusPublished - 01-04-2006

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Chromogranin A
Schizophrenia
Population
Genes
Haplotypes
Single Nucleotide Polymorphism
Prefrontal Cortex
Cerebrospinal Fluid

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Takahashi, N., Ishihara, R., Saito, S., Maemo, N., Aoyama, N., Ji, X., ... Inada, T. (2006). Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population. Schizophrenia Research, 83(2-3), 179-183. https://doi.org/10.1016/j.schres.2005.12.854
Takahashi, Nagahide ; Ishihara, Ryoko ; Saito, Shinichi ; Maemo, Nobuhisa ; Aoyama, Nagisa ; Ji, Xiofei ; Miura, Hideki ; Ikeda, Masashi ; Iwata, Nakao ; Suzuki, Tatsuyo ; Kitajima, Tsuyoshi ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Ozaki, Norio ; Inada, Toshiya. / Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population. In: Schizophrenia Research. 2006 ; Vol. 83, No. 2-3. pp. 179-183.
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Takahashi, N, Ishihara, R, Saito, S, Maemo, N, Aoyama, N, Ji, X, Miura, H, Ikeda, M, Iwata, N, Suzuki, T, Kitajima, T, Yamanouchi, Y, Kinoshita, Y, Ozaki, N & Inada, T 2006, 'Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population', Schizophrenia Research, vol. 83, no. 2-3, pp. 179-183. https://doi.org/10.1016/j.schres.2005.12.854

Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population. / Takahashi, Nagahide; Ishihara, Ryoko; Saito, Shinichi; Maemo, Nobuhisa; Aoyama, Nagisa; Ji, Xiofei; Miura, Hideki; Ikeda, Masashi; Iwata, Nakao; Suzuki, Tatsuyo; Kitajima, Tsuyoshi; Yamanouchi, Yoshio; Kinoshita, Yoko; Ozaki, Norio; Inada, Toshiya.

In: Schizophrenia Research, Vol. 83, No. 2-3, 01.04.2006, p. 179-183.

Research output: Contribution to journalArticle

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T1 - Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population

AU - Takahashi, Nagahide

AU - Ishihara, Ryoko

AU - Saito, Shinichi

AU - Maemo, Nobuhisa

AU - Aoyama, Nagisa

AU - Ji, Xiofei

AU - Miura, Hideki

AU - Ikeda, Masashi

AU - Iwata, Nakao

AU - Suzuki, Tatsuyo

AU - Kitajima, Tsuyoshi

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Ozaki, Norio

AU - Inada, Toshiya

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AB - It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p = 0.0269), and with a 2 marker haplotype (p = 0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.

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