Abstract
It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p = 0.0269), and with a 2 marker haplotype (p = 0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.
Original language | English |
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Pages (from-to) | 179-183 |
Number of pages | 5 |
Journal | Schizophrenia Research |
Volume | 83 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - 04-2006 |
All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry