Abstract
It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p = 0.0269), and with a 2 marker haplotype (p = 0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.
| Original language | English |
|---|---|
| Pages (from-to) | 179-183 |
| Number of pages | 5 |
| Journal | Schizophrenia Research |
| Volume | 83 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 01-04-2006 |
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All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry
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Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population. / Takahashi, Nagahide; Ishihara, Ryoko; Saito, Shinichi; Maemo, Nobuhisa; Aoyama, Nagisa; Ji, Xiofei; Miura, Hideki; Ikeda, Masashi; Iwata, Nakao; Suzuki, Tatsuyo; Kitajima, Tsuyoshi; Yamanouchi, Yoshio; Kinoshita, Yoko; Ozaki, Norio; Inada, Toshiya.
In: Schizophrenia Research, Vol. 83, No. 2-3, 01.04.2006, p. 179-183.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population
AU - Takahashi, Nagahide
AU - Ishihara, Ryoko
AU - Saito, Shinichi
AU - Maemo, Nobuhisa
AU - Aoyama, Nagisa
AU - Ji, Xiofei
AU - Miura, Hideki
AU - Ikeda, Masashi
AU - Iwata, Nakao
AU - Suzuki, Tatsuyo
AU - Kitajima, Tsuyoshi
AU - Yamanouchi, Yoshio
AU - Kinoshita, Yoko
AU - Ozaki, Norio
AU - Inada, Toshiya
PY - 2006/4/1
Y1 - 2006/4/1
N2 - It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p = 0.0269), and with a 2 marker haplotype (p = 0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.
AB - It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p = 0.0269), and with a 2 marker haplotype (p = 0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.
UR - http://www.scopus.com/inward/record.url?scp=33645858002&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645858002&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2005.12.854
DO - 10.1016/j.schres.2005.12.854
M3 - Article
VL - 83
SP - 179
EP - 183
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 2-3
ER -