Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population

Nagahide Takahashi; Ryoko Ishihara; Shinichi Saito; Nobuhisa Maemo; Nagisa Aoyama; Xiofei Ji; Hideki Miura; Masashi Ikeda; Nakao Iwata; Tatsuyo Suzuki; Tsuyoshi Kitajima; Yoshio Yamanouchi; Yoko Kinoshita; Norio Ozaki; Toshiya Inada

doi:10.1016/j.schres.2005.12.854

Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population

Nagahide Takahashi, Ryoko Ishihara, Shinichi Saito, Nobuhisa Maemo, Nagisa Aoyama, Xiofei Ji, Hideki Miura, Masashi Ikeda, Nakao Iwata, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Norio Ozaki, Toshiya Inada

Psychiatry

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p = 0.0269), and with a 2 marker haplotype (p = 0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.

Original language	English
Pages (from-to)	179-183
Number of pages	5
Journal	Schizophrenia Research
Volume	83
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2005.12.854
Publication status	Published - 04-2006

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2005.12.854

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Takahashi, N., Ishihara, R., Saito, S., Maemo, N., Aoyama, N., Ji, X., Miura, H., Ikeda, M., Iwata, N., Suzuki, T., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., Ozaki, N., & Inada, T. (2006). Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population. Schizophrenia Research, 83(2-3), 179-183. https://doi.org/10.1016/j.schres.2005.12.854

Takahashi, Nagahide ; Ishihara, Ryoko ; Saito, Shinichi ; Maemo, Nobuhisa ; Aoyama, Nagisa ; Ji, Xiofei ; Miura, Hideki ; Ikeda, Masashi ; Iwata, Nakao ; Suzuki, Tatsuyo ; Kitajima, Tsuyoshi ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Ozaki, Norio ; Inada, Toshiya. / Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population. In: Schizophrenia Research. 2006 ; Vol. 83, No. 2-3. pp. 179-183.

@article{f562f385ade04c769f66b9038a26ffa4,

title = "Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population",

abstract = "It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p = 0.0269), and with a 2 marker haplotype (p = 0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.",

author = "Nagahide Takahashi and Ryoko Ishihara and Shinichi Saito and Nobuhisa Maemo and Nagisa Aoyama and Xiofei Ji and Hideki Miura and Masashi Ikeda and Nakao Iwata and Tatsuyo Suzuki and Tsuyoshi Kitajima and Yoshio Yamanouchi and Yoko Kinoshita and Norio Ozaki and Toshiya Inada",

note = "Funding Information: This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science, and Technology, the Ministry of Health, Labor and Welfare, and the Japan Health Sciences Foundation (Research on Health Sciences focusing on Drug Innovation).",

year = "2006",

month = apr,

doi = "10.1016/j.schres.2005.12.854",

language = "English",

volume = "83",

pages = "179--183",

journal = "Schizophrenia Research",

issn = "0920-9964",

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Takahashi, N, Ishihara, R, Saito, S, Maemo, N, Aoyama, N, Ji, X, Miura, H, Ikeda, M , Iwata, N, Suzuki, T, Kitajima, T, Yamanouchi, Y, Kinoshita, Y, Ozaki, N & Inada, T 2006, 'Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population', Schizophrenia Research, vol. 83, no. 2-3, pp. 179-183. https://doi.org/10.1016/j.schres.2005.12.854

Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population. / Takahashi, Nagahide; Ishihara, Ryoko; Saito, Shinichi; Maemo, Nobuhisa; Aoyama, Nagisa; Ji, Xiofei; Miura, Hideki; Ikeda, Masashi ; Iwata, Nakao; Suzuki, Tatsuyo; Kitajima, Tsuyoshi; Yamanouchi, Yoshio; Kinoshita, Yoko; Ozaki, Norio; Inada, Toshiya.

In: Schizophrenia Research, Vol. 83, No. 2-3, 04.2006, p. 179-183.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population

AU - Takahashi, Nagahide

AU - Ishihara, Ryoko

AU - Saito, Shinichi

AU - Maemo, Nobuhisa

AU - Aoyama, Nagisa

AU - Ji, Xiofei

AU - Miura, Hideki

AU - Ikeda, Masashi

AU - Iwata, Nakao

AU - Suzuki, Tatsuyo

AU - Kitajima, Tsuyoshi

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Ozaki, Norio

AU - Inada, Toshiya

N1 - Funding Information: This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science, and Technology, the Ministry of Health, Labor and Welfare, and the Japan Health Sciences Foundation (Research on Health Sciences focusing on Drug Innovation).

PY - 2006/4

Y1 - 2006/4

N2 - It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p = 0.0269), and with a 2 marker haplotype (p = 0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.

AB - It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p = 0.0269), and with a 2 marker haplotype (p = 0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.

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JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 2-3

ER -

Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population

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