Association between circulating microRNAs and changes in kidney function: A five-year prospective study among Japanese adults without CKD

Ryosuke Fujii, Hiroya Yamada, Yoshiki Tsuboi, Yoshitaka Ando, Eiji Munetsuna, Mirai Yamazaki, Koji Ohashi, Hiroaki Ishikawa, Yuya Ishihara, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Although a number of microRNAs (miRNA) reflecting kidney function has been identified, prospective studies are now urgently needed to determine a clinical utility of these miRNAs among general populations. The purpose of this study was to examine the associations between serum miRNAs and kidney function in a population-based study. Methods: We conducted a five-year prospective study (2012–2017) of 169 individuals without chronic kidney disease (CKD) at the baseline survey (mean age, 62.5; 96 women). The real-time qPCR was used to measure serum levels of five previously reported miRNAs. Participants with eGFR < 60 mL/min/1.73 m2 were defined as having CKD. Changes in eGFR were defined as eGFR2017 − eGFR2012. Results: After adjusting for covariates including baseline eGFR, lower serum levels (1st tertile) of miR-126 were associated with a greater decline of eGFR (β [SE] = −3.18 [1.50]) and a higher odds ratio (OR) of CKD onset over five years (OR [95% CI] = 3.85 [1.01–16.8]), compared with the 3rd tertile. Conclusions: We found baseline serum miR-126 levels were associated with changes in eGFR and new CKD cases in a five-year prospective study. This result suggests that miR-126 may be a potential biomarker of CKD even among general populations.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalClinica Chimica Acta
Volume521
DOIs
Publication statusPublished - 10-2021

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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