Abstract
Cytomegalovirus (CMV) causes serious infection in individuals with deficient T cell immunity. In acquired immunodeficiency syndrome, the retina is a major site of progressive infection, despite the availability of therapy that targets CMV. The administration of highly active antiretroviral therapy to suppress human immunodeficiency virus frequently results in resolution of CMV retinitis, but this may be complicated by ocular inflammation termed "immune recovery uveitis" (IRU). To provide insight into the pathogenesis of IRU, the phenotype and specificity of intraocular T cells in a single patient were analyzed. The T cell infiltrate consisted of a diverse population of CD8+CMV-specific T cells, but only a minority of these T cells recognized the CMV phosphoprotein 65 and immediate early protein 1, which have been considered major targets of the host response. These results imply that reconstitution of CMV-specific T cells plays a role in IRU and suggest that the specificity of T cells engaged in the control of CMV at local sites of reactivation may be broad.
| Original language | English |
|---|---|
| Pages (from-to) | 701-705 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 186 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 01-09-2002 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Infectious Diseases
Cite this
}
Association between immune recovery uveitis and a diverse intraocular cytomegalovirus-specific cytotoxic T cell response. / Mutimer, Helen P.; Akatsuka, Yoshiki; Manley, Thomas; Chuang, Elaine L.; Boeckh, Michael; Harrington, Robert; Jones, Thomas; Riddell, Stanley R.
In: Journal of Infectious Diseases, Vol. 186, No. 5, 01.09.2002, p. 701-705.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association between immune recovery uveitis and a diverse intraocular cytomegalovirus-specific cytotoxic T cell response
AU - Mutimer, Helen P.
AU - Akatsuka, Yoshiki
AU - Manley, Thomas
AU - Chuang, Elaine L.
AU - Boeckh, Michael
AU - Harrington, Robert
AU - Jones, Thomas
AU - Riddell, Stanley R.
PY - 2002/9/1
Y1 - 2002/9/1
N2 - Cytomegalovirus (CMV) causes serious infection in individuals with deficient T cell immunity. In acquired immunodeficiency syndrome, the retina is a major site of progressive infection, despite the availability of therapy that targets CMV. The administration of highly active antiretroviral therapy to suppress human immunodeficiency virus frequently results in resolution of CMV retinitis, but this may be complicated by ocular inflammation termed "immune recovery uveitis" (IRU). To provide insight into the pathogenesis of IRU, the phenotype and specificity of intraocular T cells in a single patient were analyzed. The T cell infiltrate consisted of a diverse population of CD8+CMV-specific T cells, but only a minority of these T cells recognized the CMV phosphoprotein 65 and immediate early protein 1, which have been considered major targets of the host response. These results imply that reconstitution of CMV-specific T cells plays a role in IRU and suggest that the specificity of T cells engaged in the control of CMV at local sites of reactivation may be broad.
AB - Cytomegalovirus (CMV) causes serious infection in individuals with deficient T cell immunity. In acquired immunodeficiency syndrome, the retina is a major site of progressive infection, despite the availability of therapy that targets CMV. The administration of highly active antiretroviral therapy to suppress human immunodeficiency virus frequently results in resolution of CMV retinitis, but this may be complicated by ocular inflammation termed "immune recovery uveitis" (IRU). To provide insight into the pathogenesis of IRU, the phenotype and specificity of intraocular T cells in a single patient were analyzed. The T cell infiltrate consisted of a diverse population of CD8+CMV-specific T cells, but only a minority of these T cells recognized the CMV phosphoprotein 65 and immediate early protein 1, which have been considered major targets of the host response. These results imply that reconstitution of CMV-specific T cells plays a role in IRU and suggest that the specificity of T cells engaged in the control of CMV at local sites of reactivation may be broad.
UR - http://www.scopus.com/inward/record.url?scp=0036720944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036720944&partnerID=8YFLogxK
U2 - 10.1086/342044
DO - 10.1086/342044
M3 - Article
C2 - 12195359
AN - SCOPUS:0036720944
VL - 186
SP - 701
EP - 705
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 5
ER -