TY - JOUR
T1 - Association between insertion/deletion polymorphism in angiotensin-converting enzyme gene and acute lung injury/acute respiratory distress syndrome
T2 - a meta-analysis
AU - Matsuda, Akihisa
AU - Kishi, Taro
AU - Jacob, Asha
AU - Aziz, Monowar
AU - Wang, Ping
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/8/31
Y1 - 2012/8/31
N2 - Background: A previous meta-analysis reported a positive association between an insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene (ACE) and the risk of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Here, we updated this meta-analysis and additionally assessed the association of this polymorphism with ALI/ARDS mortality.Methods: We searched electronic databases through October 2011 for the terms " angiotensin-converting enzyme gene" , " acute lung injury" , and " acute respiratory distress syndrome," and reviewed all studies that reported the relationship of the I/D polymorphism in ACE with ALI/ARDS in humans. Seven studies met the inclusion criteria, comprising 532 ALI/ARDS patients, 3032 healthy controls, and 1432 patients without ALI/ARDS. We used three genetic models: the allele, dominant, and recessive models.Results: The ACE I/D polymorphism was not associated with susceptibility to ALI/ARDS for any genetic model. However, the ACE I/D polymorphism was associated with the mortality risk of ALI/ARDS in Asian subjects ( Pallele < 0.0001, Pdominant = 0.001, Precessive = 0.002). This finding remained significant after correction for multiple comparisons.Conclusions: There is a possible association between the ACE I/D polymorphism genotype and the mortality risk of ALI/ARDS in Asians.
AB - Background: A previous meta-analysis reported a positive association between an insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene (ACE) and the risk of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Here, we updated this meta-analysis and additionally assessed the association of this polymorphism with ALI/ARDS mortality.Methods: We searched electronic databases through October 2011 for the terms " angiotensin-converting enzyme gene" , " acute lung injury" , and " acute respiratory distress syndrome," and reviewed all studies that reported the relationship of the I/D polymorphism in ACE with ALI/ARDS in humans. Seven studies met the inclusion criteria, comprising 532 ALI/ARDS patients, 3032 healthy controls, and 1432 patients without ALI/ARDS. We used three genetic models: the allele, dominant, and recessive models.Results: The ACE I/D polymorphism was not associated with susceptibility to ALI/ARDS for any genetic model. However, the ACE I/D polymorphism was associated with the mortality risk of ALI/ARDS in Asian subjects ( Pallele < 0.0001, Pdominant = 0.001, Precessive = 0.002). This finding remained significant after correction for multiple comparisons.Conclusions: There is a possible association between the ACE I/D polymorphism genotype and the mortality risk of ALI/ARDS in Asians.
UR - http://www.scopus.com/inward/record.url?scp=84865548691&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865548691&partnerID=8YFLogxK
U2 - 10.1186/1471-2350-13-76
DO - 10.1186/1471-2350-13-76
M3 - Article
C2 - 22938636
AN - SCOPUS:84865548691
VL - 13
JO - BMC Medical Genetics
JF - BMC Medical Genetics
SN - 1471-2350
M1 - 76
ER -