Association between interleukin-1β and tumor necrosis factor-α polymorphisms and symptoms of dyspepsia

Tomomitsu Tahara, Tomoyuki Shibata, Masaaki Okubo, Takamitsu Ishizuka, Tomohiko Kawamura, Hiromi Yamashita, Masakatsu Nakamura, Yoshihito Nakagawa, Mitsuo Nagasaka, Tomiyasu Arisawa, Naoki Omiya, Ichiro Hirata

Research output: Contribution to journalArticle

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Abstract

Interleukin (IL)-1β, and tumor necrosis factor (TNF)-α have significant roles in the mediation of inflammatory immune responses and are also potent inhibitors of gastric acid secretion in the stomach. The present study aimed to investigate the associations between polymorphisms at position -31 (T>C) of the IL-1β gene and -857 (C>T) of the TNF-α gene with dyspeptic symptoms. Polymorphisms at position -31 (T>C) of the IL-1β gene and -857 (C>T) of the TNF-α gene were genotyped in 261 subjects, including 126 subjects without symptoms and 135 subjects exhibiting symptoms of dyspepsia. The IL-1β -31 CC genotype was inversely associated with dyspeptic symptoms in all subjects, as determined by the Fisher's exact test [odds ratio (OR), 0.57; 95% confidence interval (CI), 0.34-0.96; P=0.046]; however, this association was not detected following logistic regression analysis. Within the subgroups of symptoms, the CC genotype was also inversely associated with upper abdominal pain (OR, 0.28; 95% CI, 0.12-0.67; P=0.003) and epigastric pain syndrome (EPS)-like symptoms (OR, 0.14; 95% CI, 0.07-0.28; P=0.003), according to the Rome III classifications. These associations were also found following logistic regression analysis (upper abdominal pain: OR, 0.34; 95% CI, 0.14-0.80; P=0.014; and EPS-like symptoms: OR, 0.41; 95% CI, 0.20-0.84; P=0.015). No significant associations were identified between the TNF-α -857 polymorphism and dyspeptic symptoms, including amongst the various subtypes analyzed. In conclusion, the IL-1β -31 CC genotype was inversely associated with susceptibility to dyspeptic symptoms, in particular, upper abdominal pain and EPS-like symptoms.

Original languageEnglish
Pages (from-to)3888-3893
Number of pages6
JournalMolecular Medicine Reports
Volume11
Issue number5
DOIs
Publication statusPublished - 01-05-2015

Fingerprint

Dyspepsia
Polymorphism
Interleukin-1
Tumor Necrosis Factor-alpha
Odds Ratio
Confidence Intervals
Genes
Abdominal Pain
Genotype
Pain
Regression analysis
Logistics
Logistic Models
Regression Analysis
Gastric Acid
Stomach
Acids

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Oncology
  • Cancer Research

Cite this

Tahara, Tomomitsu ; Shibata, Tomoyuki ; Okubo, Masaaki ; Ishizuka, Takamitsu ; Kawamura, Tomohiko ; Yamashita, Hiromi ; Nakamura, Masakatsu ; Nakagawa, Yoshihito ; Nagasaka, Mitsuo ; Arisawa, Tomiyasu ; Omiya, Naoki ; Hirata, Ichiro. / Association between interleukin-1β and tumor necrosis factor-α polymorphisms and symptoms of dyspepsia. In: Molecular Medicine Reports. 2015 ; Vol. 11, No. 5. pp. 3888-3893.
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abstract = "Interleukin (IL)-1β, and tumor necrosis factor (TNF)-α have significant roles in the mediation of inflammatory immune responses and are also potent inhibitors of gastric acid secretion in the stomach. The present study aimed to investigate the associations between polymorphisms at position -31 (T>C) of the IL-1β gene and -857 (C>T) of the TNF-α gene with dyspeptic symptoms. Polymorphisms at position -31 (T>C) of the IL-1β gene and -857 (C>T) of the TNF-α gene were genotyped in 261 subjects, including 126 subjects without symptoms and 135 subjects exhibiting symptoms of dyspepsia. The IL-1β -31 CC genotype was inversely associated with dyspeptic symptoms in all subjects, as determined by the Fisher's exact test [odds ratio (OR), 0.57; 95{\%} confidence interval (CI), 0.34-0.96; P=0.046]; however, this association was not detected following logistic regression analysis. Within the subgroups of symptoms, the CC genotype was also inversely associated with upper abdominal pain (OR, 0.28; 95{\%} CI, 0.12-0.67; P=0.003) and epigastric pain syndrome (EPS)-like symptoms (OR, 0.14; 95{\%} CI, 0.07-0.28; P=0.003), according to the Rome III classifications. These associations were also found following logistic regression analysis (upper abdominal pain: OR, 0.34; 95{\%} CI, 0.14-0.80; P=0.014; and EPS-like symptoms: OR, 0.41; 95{\%} CI, 0.20-0.84; P=0.015). No significant associations were identified between the TNF-α -857 polymorphism and dyspeptic symptoms, including amongst the various subtypes analyzed. In conclusion, the IL-1β -31 CC genotype was inversely associated with susceptibility to dyspeptic symptoms, in particular, upper abdominal pain and EPS-like symptoms.",
author = "Tomomitsu Tahara and Tomoyuki Shibata and Masaaki Okubo and Takamitsu Ishizuka and Tomohiko Kawamura and Hiromi Yamashita and Masakatsu Nakamura and Yoshihito Nakagawa and Mitsuo Nagasaka and Tomiyasu Arisawa and Naoki Omiya and Ichiro Hirata",
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Tahara, T, Shibata, T, Okubo, M, Ishizuka, T, Kawamura, T, Yamashita, H, Nakamura, M, Nakagawa, Y, Nagasaka, M, Arisawa, T, Omiya, N & Hirata, I 2015, 'Association between interleukin-1β and tumor necrosis factor-α polymorphisms and symptoms of dyspepsia', Molecular Medicine Reports, vol. 11, no. 5, pp. 3888-3893. https://doi.org/10.3892/mmr.2015.3163

Association between interleukin-1β and tumor necrosis factor-α polymorphisms and symptoms of dyspepsia. / Tahara, Tomomitsu; Shibata, Tomoyuki; Okubo, Masaaki; Ishizuka, Takamitsu; Kawamura, Tomohiko; Yamashita, Hiromi; Nakamura, Masakatsu; Nakagawa, Yoshihito; Nagasaka, Mitsuo; Arisawa, Tomiyasu; Omiya, Naoki; Hirata, Ichiro.

In: Molecular Medicine Reports, Vol. 11, No. 5, 01.05.2015, p. 3888-3893.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between interleukin-1β and tumor necrosis factor-α polymorphisms and symptoms of dyspepsia

AU - Tahara, Tomomitsu

AU - Shibata, Tomoyuki

AU - Okubo, Masaaki

AU - Ishizuka, Takamitsu

AU - Kawamura, Tomohiko

AU - Yamashita, Hiromi

AU - Nakamura, Masakatsu

AU - Nakagawa, Yoshihito

AU - Nagasaka, Mitsuo

AU - Arisawa, Tomiyasu

AU - Omiya, Naoki

AU - Hirata, Ichiro

PY - 2015/5/1

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N2 - Interleukin (IL)-1β, and tumor necrosis factor (TNF)-α have significant roles in the mediation of inflammatory immune responses and are also potent inhibitors of gastric acid secretion in the stomach. The present study aimed to investigate the associations between polymorphisms at position -31 (T>C) of the IL-1β gene and -857 (C>T) of the TNF-α gene with dyspeptic symptoms. Polymorphisms at position -31 (T>C) of the IL-1β gene and -857 (C>T) of the TNF-α gene were genotyped in 261 subjects, including 126 subjects without symptoms and 135 subjects exhibiting symptoms of dyspepsia. The IL-1β -31 CC genotype was inversely associated with dyspeptic symptoms in all subjects, as determined by the Fisher's exact test [odds ratio (OR), 0.57; 95% confidence interval (CI), 0.34-0.96; P=0.046]; however, this association was not detected following logistic regression analysis. Within the subgroups of symptoms, the CC genotype was also inversely associated with upper abdominal pain (OR, 0.28; 95% CI, 0.12-0.67; P=0.003) and epigastric pain syndrome (EPS)-like symptoms (OR, 0.14; 95% CI, 0.07-0.28; P=0.003), according to the Rome III classifications. These associations were also found following logistic regression analysis (upper abdominal pain: OR, 0.34; 95% CI, 0.14-0.80; P=0.014; and EPS-like symptoms: OR, 0.41; 95% CI, 0.20-0.84; P=0.015). No significant associations were identified between the TNF-α -857 polymorphism and dyspeptic symptoms, including amongst the various subtypes analyzed. In conclusion, the IL-1β -31 CC genotype was inversely associated with susceptibility to dyspeptic symptoms, in particular, upper abdominal pain and EPS-like symptoms.

AB - Interleukin (IL)-1β, and tumor necrosis factor (TNF)-α have significant roles in the mediation of inflammatory immune responses and are also potent inhibitors of gastric acid secretion in the stomach. The present study aimed to investigate the associations between polymorphisms at position -31 (T>C) of the IL-1β gene and -857 (C>T) of the TNF-α gene with dyspeptic symptoms. Polymorphisms at position -31 (T>C) of the IL-1β gene and -857 (C>T) of the TNF-α gene were genotyped in 261 subjects, including 126 subjects without symptoms and 135 subjects exhibiting symptoms of dyspepsia. The IL-1β -31 CC genotype was inversely associated with dyspeptic symptoms in all subjects, as determined by the Fisher's exact test [odds ratio (OR), 0.57; 95% confidence interval (CI), 0.34-0.96; P=0.046]; however, this association was not detected following logistic regression analysis. Within the subgroups of symptoms, the CC genotype was also inversely associated with upper abdominal pain (OR, 0.28; 95% CI, 0.12-0.67; P=0.003) and epigastric pain syndrome (EPS)-like symptoms (OR, 0.14; 95% CI, 0.07-0.28; P=0.003), according to the Rome III classifications. These associations were also found following logistic regression analysis (upper abdominal pain: OR, 0.34; 95% CI, 0.14-0.80; P=0.014; and EPS-like symptoms: OR, 0.41; 95% CI, 0.20-0.84; P=0.015). No significant associations were identified between the TNF-α -857 polymorphism and dyspeptic symptoms, including amongst the various subtypes analyzed. In conclusion, the IL-1β -31 CC genotype was inversely associated with susceptibility to dyspeptic symptoms, in particular, upper abdominal pain and EPS-like symptoms.

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