TY - JOUR
T1 - Association between interleukin-1β and tumor necrosis factor-α polymorphisms and symptoms of dyspepsia
AU - Tahara, Tomomitsu
AU - Shibata, Tomoyuki
AU - Okubo, Masaaki
AU - Ishizuka, Takamitsu
AU - Kawamura, Tomohiko
AU - Yamashita, Hiromi
AU - Nakamura, Masakatsu
AU - Nakagawa, Yoshihito
AU - Nagasaka, Mitsuo
AU - Arisawa, Tomiyasu
AU - Ohmiya, Naoki
AU - Hirata, Ichiro
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Interleukin (IL)-1β, and tumor necrosis factor (TNF)-α have significant roles in the mediation of inflammatory immune responses and are also potent inhibitors of gastric acid secretion in the stomach. The present study aimed to investigate the associations between polymorphisms at position -31 (T>C) of the IL-1β gene and -857 (C>T) of the TNF-α gene with dyspeptic symptoms. Polymorphisms at position -31 (T>C) of the IL-1β gene and -857 (C>T) of the TNF-α gene were genotyped in 261 subjects, including 126 subjects without symptoms and 135 subjects exhibiting symptoms of dyspepsia. The IL-1β -31 CC genotype was inversely associated with dyspeptic symptoms in all subjects, as determined by the Fisher's exact test [odds ratio (OR), 0.57; 95% confidence interval (CI), 0.34-0.96; P=0.046]; however, this association was not detected following logistic regression analysis. Within the subgroups of symptoms, the CC genotype was also inversely associated with upper abdominal pain (OR, 0.28; 95% CI, 0.12-0.67; P=0.003) and epigastric pain syndrome (EPS)-like symptoms (OR, 0.14; 95% CI, 0.07-0.28; P=0.003), according to the Rome III classifications. These associations were also found following logistic regression analysis (upper abdominal pain: OR, 0.34; 95% CI, 0.14-0.80; P=0.014; and EPS-like symptoms: OR, 0.41; 95% CI, 0.20-0.84; P=0.015). No significant associations were identified between the TNF-α -857 polymorphism and dyspeptic symptoms, including amongst the various subtypes analyzed. In conclusion, the IL-1β -31 CC genotype was inversely associated with susceptibility to dyspeptic symptoms, in particular, upper abdominal pain and EPS-like symptoms.
AB - Interleukin (IL)-1β, and tumor necrosis factor (TNF)-α have significant roles in the mediation of inflammatory immune responses and are also potent inhibitors of gastric acid secretion in the stomach. The present study aimed to investigate the associations between polymorphisms at position -31 (T>C) of the IL-1β gene and -857 (C>T) of the TNF-α gene with dyspeptic symptoms. Polymorphisms at position -31 (T>C) of the IL-1β gene and -857 (C>T) of the TNF-α gene were genotyped in 261 subjects, including 126 subjects without symptoms and 135 subjects exhibiting symptoms of dyspepsia. The IL-1β -31 CC genotype was inversely associated with dyspeptic symptoms in all subjects, as determined by the Fisher's exact test [odds ratio (OR), 0.57; 95% confidence interval (CI), 0.34-0.96; P=0.046]; however, this association was not detected following logistic regression analysis. Within the subgroups of symptoms, the CC genotype was also inversely associated with upper abdominal pain (OR, 0.28; 95% CI, 0.12-0.67; P=0.003) and epigastric pain syndrome (EPS)-like symptoms (OR, 0.14; 95% CI, 0.07-0.28; P=0.003), according to the Rome III classifications. These associations were also found following logistic regression analysis (upper abdominal pain: OR, 0.34; 95% CI, 0.14-0.80; P=0.014; and EPS-like symptoms: OR, 0.41; 95% CI, 0.20-0.84; P=0.015). No significant associations were identified between the TNF-α -857 polymorphism and dyspeptic symptoms, including amongst the various subtypes analyzed. In conclusion, the IL-1β -31 CC genotype was inversely associated with susceptibility to dyspeptic symptoms, in particular, upper abdominal pain and EPS-like symptoms.
KW - Dyspepsia
KW - Functional dyspepsia
KW - Interleukin-1β
KW - Polymorphism
KW - Tumor necrosis factor-α
UR - http://www.scopus.com/inward/record.url?scp=84922294243&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922294243&partnerID=8YFLogxK
U2 - 10.3892/mmr.2015.3163
DO - 10.3892/mmr.2015.3163
M3 - Article
C2 - 25571868
AN - SCOPUS:84922294243
SN - 1791-2997
VL - 11
SP - 3888
EP - 3893
JO - Molecular Medicine Reports
JF - Molecular Medicine Reports
IS - 5
ER -