Association between interleukin-1B C-31T polymorphism and obesity in Japanese

Koji Suzuki, Takashi Inoue, Atsumi Yanagisawa, Asami Kimura, Yoshinori Ito, Nobuyuki Hamajima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Recent studies have revealed a close relationship between obesity and polymorphism in the inflammation gene. However, the association between interleukin-1beta (IL-1β) and obesity remains controversial. We therefore investigated the association between IL-1B C-31T polymorphism and obesity in Japanese. Methods: The participants were 802 inhabitants (281 men and 521 women) of Japan, aged 39 to 88 years, who attended a health examination in 2003. Body height, weight, waist and hip circumferences, and body fat percentage were measured. The IL-1B C-31T polymorphism was genotyped by polymerase chain reaction with confronting 2-pair primers. The association between IL-1B C-31T genotypes and various indices of obesity was then investigated. The confounding factor-adjusted odds ratios (OR) and 95% confidence intervals (CI) for obesity were calculated for each IL-1B C-31T genotype by using unconditional logistic regression analysis. Results: Among male carriers of the CT and TT genotypes, the ORs for high body fat percentage were 2.58 (95% CI, 1.17-6.34) and 2.81 (1.17-7.33), respectively, as compared to carriers of the CC genotype (P for trend = 0.037). Among women, carriers of the TT genotype had significantly higher ORs for high BMI (OR, 2.13; 95% CI, 1.25-3.67) and large waist circumference (2.49; 1.37-4.66), as compared to women with the CC genotype (P for trend = 0.005 and 0.004, respectively). Conclusions: The IL-1B C-31T polymorphism is associated with obesity in Japanese. Men and women with the TT genotype of IL-1B C-31T had a higher risk for obesity than those with the CC genotype.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalJournal of epidemiology
Volume19
Issue number3
DOIs
Publication statusPublished - 31-08-2009

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Interleukins
Obesity
Genotype
Waist Circumference
Confidence Intervals
Adipose Tissue
Odds Ratio
Body Height
Interleukin-1beta
Hip
Japan
Logistic Models
Body Weight
Regression Analysis
Inflammation
Polymerase Chain Reaction
Health
Genes

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Suzuki, Koji ; Inoue, Takashi ; Yanagisawa, Atsumi ; Kimura, Asami ; Ito, Yoshinori ; Hamajima, Nobuyuki. / Association between interleukin-1B C-31T polymorphism and obesity in Japanese. In: Journal of epidemiology. 2009 ; Vol. 19, No. 3. pp. 131-135.
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abstract = "Background: Recent studies have revealed a close relationship between obesity and polymorphism in the inflammation gene. However, the association between interleukin-1beta (IL-1β) and obesity remains controversial. We therefore investigated the association between IL-1B C-31T polymorphism and obesity in Japanese. Methods: The participants were 802 inhabitants (281 men and 521 women) of Japan, aged 39 to 88 years, who attended a health examination in 2003. Body height, weight, waist and hip circumferences, and body fat percentage were measured. The IL-1B C-31T polymorphism was genotyped by polymerase chain reaction with confronting 2-pair primers. The association between IL-1B C-31T genotypes and various indices of obesity was then investigated. The confounding factor-adjusted odds ratios (OR) and 95{\%} confidence intervals (CI) for obesity were calculated for each IL-1B C-31T genotype by using unconditional logistic regression analysis. Results: Among male carriers of the CT and TT genotypes, the ORs for high body fat percentage were 2.58 (95{\%} CI, 1.17-6.34) and 2.81 (1.17-7.33), respectively, as compared to carriers of the CC genotype (P for trend = 0.037). Among women, carriers of the TT genotype had significantly higher ORs for high BMI (OR, 2.13; 95{\%} CI, 1.25-3.67) and large waist circumference (2.49; 1.37-4.66), as compared to women with the CC genotype (P for trend = 0.005 and 0.004, respectively). Conclusions: The IL-1B C-31T polymorphism is associated with obesity in Japanese. Men and women with the TT genotype of IL-1B C-31T had a higher risk for obesity than those with the CC genotype.",
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Suzuki, K, Inoue, T, Yanagisawa, A, Kimura, A, Ito, Y & Hamajima, N 2009, 'Association between interleukin-1B C-31T polymorphism and obesity in Japanese', Journal of epidemiology, vol. 19, no. 3, pp. 131-135. https://doi.org/10.2188/jea.JE20081015

Association between interleukin-1B C-31T polymorphism and obesity in Japanese. / Suzuki, Koji; Inoue, Takashi; Yanagisawa, Atsumi; Kimura, Asami; Ito, Yoshinori; Hamajima, Nobuyuki.

In: Journal of epidemiology, Vol. 19, No. 3, 31.08.2009, p. 131-135.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between interleukin-1B C-31T polymorphism and obesity in Japanese

AU - Suzuki, Koji

AU - Inoue, Takashi

AU - Yanagisawa, Atsumi

AU - Kimura, Asami

AU - Ito, Yoshinori

AU - Hamajima, Nobuyuki

PY - 2009/8/31

Y1 - 2009/8/31

N2 - Background: Recent studies have revealed a close relationship between obesity and polymorphism in the inflammation gene. However, the association between interleukin-1beta (IL-1β) and obesity remains controversial. We therefore investigated the association between IL-1B C-31T polymorphism and obesity in Japanese. Methods: The participants were 802 inhabitants (281 men and 521 women) of Japan, aged 39 to 88 years, who attended a health examination in 2003. Body height, weight, waist and hip circumferences, and body fat percentage were measured. The IL-1B C-31T polymorphism was genotyped by polymerase chain reaction with confronting 2-pair primers. The association between IL-1B C-31T genotypes and various indices of obesity was then investigated. The confounding factor-adjusted odds ratios (OR) and 95% confidence intervals (CI) for obesity were calculated for each IL-1B C-31T genotype by using unconditional logistic regression analysis. Results: Among male carriers of the CT and TT genotypes, the ORs for high body fat percentage were 2.58 (95% CI, 1.17-6.34) and 2.81 (1.17-7.33), respectively, as compared to carriers of the CC genotype (P for trend = 0.037). Among women, carriers of the TT genotype had significantly higher ORs for high BMI (OR, 2.13; 95% CI, 1.25-3.67) and large waist circumference (2.49; 1.37-4.66), as compared to women with the CC genotype (P for trend = 0.005 and 0.004, respectively). Conclusions: The IL-1B C-31T polymorphism is associated with obesity in Japanese. Men and women with the TT genotype of IL-1B C-31T had a higher risk for obesity than those with the CC genotype.

AB - Background: Recent studies have revealed a close relationship between obesity and polymorphism in the inflammation gene. However, the association between interleukin-1beta (IL-1β) and obesity remains controversial. We therefore investigated the association between IL-1B C-31T polymorphism and obesity in Japanese. Methods: The participants were 802 inhabitants (281 men and 521 women) of Japan, aged 39 to 88 years, who attended a health examination in 2003. Body height, weight, waist and hip circumferences, and body fat percentage were measured. The IL-1B C-31T polymorphism was genotyped by polymerase chain reaction with confronting 2-pair primers. The association between IL-1B C-31T genotypes and various indices of obesity was then investigated. The confounding factor-adjusted odds ratios (OR) and 95% confidence intervals (CI) for obesity were calculated for each IL-1B C-31T genotype by using unconditional logistic regression analysis. Results: Among male carriers of the CT and TT genotypes, the ORs for high body fat percentage were 2.58 (95% CI, 1.17-6.34) and 2.81 (1.17-7.33), respectively, as compared to carriers of the CC genotype (P for trend = 0.037). Among women, carriers of the TT genotype had significantly higher ORs for high BMI (OR, 2.13; 95% CI, 1.25-3.67) and large waist circumference (2.49; 1.37-4.66), as compared to women with the CC genotype (P for trend = 0.005 and 0.004, respectively). Conclusions: The IL-1B C-31T polymorphism is associated with obesity in Japanese. Men and women with the TT genotype of IL-1B C-31T had a higher risk for obesity than those with the CC genotype.

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