TY - JOUR
T1 - Association between low birth weight and elevated white blood cell count in adulthood within a Japanese population
AU - Wada, Keiko
AU - Tamakoshi, Koji
AU - Ouyang, Pei
AU - Otsuka, Rei
AU - Mitsuhashi, Hirotsugu
AU - Takefuji, Seiko
AU - Matsushita, Kunihiro
AU - Sugiura, Kaichiro
AU - Hotta, Yo
AU - Toyoshima, Hideaki
AU - Yatsuya, Hiroshi
PY - 2008
Y1 - 2008
N2 - Background: Epidemiological studies have demonstrated the association between low birth weight and increased adulthood risk for cardiovascular and metabolic diseases. However, the precise mechanism underlying the association remains poorly understood. We investigated the association between birth weight and adult white blood cell (WBC) count in a Japanese population. Methods and Results: The subjects were 779 men and 209 women aged 35-64 years. The mean WBC count was 5,283 /μl (SD: 1,326). Birth weight was divided to 6 categories: <2,500, 2,500-<2,800, 2,800-<3,000, 3,000-<3,200, 3,200-<3,500, and >3,500 g. Estimated WBC counts were 5,729, 5,341, 5,301, 5,212, 5,013 and 5,372 for the subjects with birth weights of the above respective categories (p=0.015, trend p=0.016) by one-way analysis of covariance after adjustments for sex, age, height, body mass index (BMI), lifestyles, and chronic diseases. This association was pronounced among the subjects with a BMI <25.0 kg/m 2 rather than those with a higher BMI. Conclusions: These findings support the idea that part of the association of low birth weight with elevated risk for vascular and metabolic diseases in later life could be mediated by an inflammatory pathway.
AB - Background: Epidemiological studies have demonstrated the association between low birth weight and increased adulthood risk for cardiovascular and metabolic diseases. However, the precise mechanism underlying the association remains poorly understood. We investigated the association between birth weight and adult white blood cell (WBC) count in a Japanese population. Methods and Results: The subjects were 779 men and 209 women aged 35-64 years. The mean WBC count was 5,283 /μl (SD: 1,326). Birth weight was divided to 6 categories: <2,500, 2,500-<2,800, 2,800-<3,000, 3,000-<3,200, 3,200-<3,500, and >3,500 g. Estimated WBC counts were 5,729, 5,341, 5,301, 5,212, 5,013 and 5,372 for the subjects with birth weights of the above respective categories (p=0.015, trend p=0.016) by one-way analysis of covariance after adjustments for sex, age, height, body mass index (BMI), lifestyles, and chronic diseases. This association was pronounced among the subjects with a BMI <25.0 kg/m 2 rather than those with a higher BMI. Conclusions: These findings support the idea that part of the association of low birth weight with elevated risk for vascular and metabolic diseases in later life could be mediated by an inflammatory pathway.
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U2 - 10.1253/circj.72.757
DO - 10.1253/circj.72.757
M3 - Article
C2 - 18441456
AN - SCOPUS:44149098828
SN - 1346-9843
VL - 72
SP - 757
EP - 763
JO - Circulation Journal
JF - Circulation Journal
IS - 5
ER -