Association between multiscale entropy characteristics of heart rate variability and ischemic stroke risk in patients with permanent atrial fibrillation

Ryo Matsuoka, Kohzoh Yoshino, Eiichi Watanabe, Ken Kiyono

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Multiscale entropy (MSE) profiles of heart rate variability (HRV) in patients with atrial fibrillation (AFib) provides clinically useful information for ischemic stroke risk assessment, suggesting that the complex properties characterized by MSE profiles are associated with ischemic stroke risk. However, the meaning of HRV complexity in patients with AFib has not been clearly interpreted, and the physical and mathematical understanding of the relation between HRV dynamics and the ischemic stroke risk is not well established. To gain a deeper insight into HRV dynamics in patients with AFib, and to improve ischemic stroke risk assessment using HRV analysis, we study the HRV characteristics related to MSE profiles, such as the long-range correlation and probability density function. In this study, we analyze the HRV time series of 173 patients with permanent AFib. Our results show that, although HRV time series in patients with AFib exhibit long-range correlation (1/f fluctuations)-as observed in healthy subjects-in a range longer than 90 s, these autocorrelation properties have no significant predictive power for ischemic stroke occurrence. Further, the probability density function structure of the coarse-grained times series at scales greater than 2 s is dominantly associated with ischemic stroke risk. This observation could provide valuable information for improving ischemic stroke risk assessment using HRV analysis.

Original languageEnglish
Article number672
JournalEntropy
Volume19
Issue number12
DOIs
Publication statusPublished - 01-12-2017

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fibrillation
heart rate
strokes
entropy
risk assessment
probability density functions
profiles
autocorrelation
occurrences

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Cite this

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title = "Association between multiscale entropy characteristics of heart rate variability and ischemic stroke risk in patients with permanent atrial fibrillation",
abstract = "Multiscale entropy (MSE) profiles of heart rate variability (HRV) in patients with atrial fibrillation (AFib) provides clinically useful information for ischemic stroke risk assessment, suggesting that the complex properties characterized by MSE profiles are associated with ischemic stroke risk. However, the meaning of HRV complexity in patients with AFib has not been clearly interpreted, and the physical and mathematical understanding of the relation between HRV dynamics and the ischemic stroke risk is not well established. To gain a deeper insight into HRV dynamics in patients with AFib, and to improve ischemic stroke risk assessment using HRV analysis, we study the HRV characteristics related to MSE profiles, such as the long-range correlation and probability density function. In this study, we analyze the HRV time series of 173 patients with permanent AFib. Our results show that, although HRV time series in patients with AFib exhibit long-range correlation (1/f fluctuations)-as observed in healthy subjects-in a range longer than 90 s, these autocorrelation properties have no significant predictive power for ischemic stroke occurrence. Further, the probability density function structure of the coarse-grained times series at scales greater than 2 s is dominantly associated with ischemic stroke risk. This observation could provide valuable information for improving ischemic stroke risk assessment using HRV analysis.",
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Association between multiscale entropy characteristics of heart rate variability and ischemic stroke risk in patients with permanent atrial fibrillation. / Matsuoka, Ryo; Yoshino, Kohzoh; Watanabe, Eiichi; Kiyono, Ken.

In: Entropy, Vol. 19, No. 12, 672, 01.12.2017.

Research output: Contribution to journalArticle

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