Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence

Yuko Okahisa, Hiroshi Ujike, Tatsuya Kotaka, Yukitaka Morita, Masafumi Kodama, Toshiya Inada, Mitsuhiko Yamada, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Shigetoshi Kuroda

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Neuropeptide Y (NPY) is a 36-amino acid peptide that is widely distributed in the brain, adrenal medulla, and sympathetic nervous system. Several lines of evidence suggest a possible involvement of the NPY system in the physiological effects of several classes of abused substances including alcohol, phencyclidine, cocaine, and marijuana and in endogenous psychosis. Accordingly, it was hypothesized that the NPY system may also be involved in methamphetamine dependence or psychosis. Methods: The single nucleotide polymorphisms rs16147 of the NPY gene (-485C>T) and rs7687423 of the NPY receptor Y1 (NPY1R) gene were analyzed in 222 patients with methamphetamine dependence and psychosis and 288 age- and gender-matched controls. Results: Genotypic distribution of the NPY1R gene showed a significant association with methamphetamine dependence and psychosis (P = 0.04), whereas the NPY gene had no significant association with them. Conclusion: It is possible that genetic variants of the NPY1R gene affect the NPY-NPY receptor type Y1 signaling system in the brain, which may result in susceptibility to methamphetamine dependence or the development of methamphetamine psychosis, but the present findings need to be confirmed on replication.

Original languageEnglish
Pages (from-to)417-422
Number of pages6
JournalPsychiatry and clinical neurosciences
Volume63
Issue number3
DOIs
Publication statusPublished - 01-06-2009

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Methamphetamine
Neuropeptide Y
Psychotic Disorders
Genes
Phencyclidine
Adrenal Medulla
Sympathetic Nervous System
Brain
Cannabis
Cocaine
Single Nucleotide Polymorphism
Alcohols
Amino Acids
Peptides

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Okahisa, Yuko ; Ujike, Hiroshi ; Kotaka, Tatsuya ; Morita, Yukitaka ; Kodama, Masafumi ; Inada, Toshiya ; Yamada, Mitsuhiko ; Iwata, Nakao ; Iyo, Masaomi ; Sora, Ichiro ; Ozaki, Norio ; Kuroda, Shigetoshi. / Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. In: Psychiatry and clinical neurosciences. 2009 ; Vol. 63, No. 3. pp. 417-422.
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abstract = "Neuropeptide Y (NPY) is a 36-amino acid peptide that is widely distributed in the brain, adrenal medulla, and sympathetic nervous system. Several lines of evidence suggest a possible involvement of the NPY system in the physiological effects of several classes of abused substances including alcohol, phencyclidine, cocaine, and marijuana and in endogenous psychosis. Accordingly, it was hypothesized that the NPY system may also be involved in methamphetamine dependence or psychosis. Methods: The single nucleotide polymorphisms rs16147 of the NPY gene (-485C>T) and rs7687423 of the NPY receptor Y1 (NPY1R) gene were analyzed in 222 patients with methamphetamine dependence and psychosis and 288 age- and gender-matched controls. Results: Genotypic distribution of the NPY1R gene showed a significant association with methamphetamine dependence and psychosis (P = 0.04), whereas the NPY gene had no significant association with them. Conclusion: It is possible that genetic variants of the NPY1R gene affect the NPY-NPY receptor type Y1 signaling system in the brain, which may result in susceptibility to methamphetamine dependence or the development of methamphetamine psychosis, but the present findings need to be confirmed on replication.",
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Okahisa, Y, Ujike, H, Kotaka, T, Morita, Y, Kodama, M, Inada, T, Yamada, M, Iwata, N, Iyo, M, Sora, I, Ozaki, N & Kuroda, S 2009, 'Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence', Psychiatry and clinical neurosciences, vol. 63, no. 3, pp. 417-422. https://doi.org/10.1111/j.1440-1819.2009.01961.x

Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. / Okahisa, Yuko; Ujike, Hiroshi; Kotaka, Tatsuya; Morita, Yukitaka; Kodama, Masafumi; Inada, Toshiya; Yamada, Mitsuhiko; Iwata, Nakao; Iyo, Masaomi; Sora, Ichiro; Ozaki, Norio; Kuroda, Shigetoshi.

In: Psychiatry and clinical neurosciences, Vol. 63, No. 3, 01.06.2009, p. 417-422.

Research output: Contribution to journalArticle

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T1 - Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence

AU - Okahisa, Yuko

AU - Ujike, Hiroshi

AU - Kotaka, Tatsuya

AU - Morita, Yukitaka

AU - Kodama, Masafumi

AU - Inada, Toshiya

AU - Yamada, Mitsuhiko

AU - Iwata, Nakao

AU - Iyo, Masaomi

AU - Sora, Ichiro

AU - Ozaki, Norio

AU - Kuroda, Shigetoshi

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Neuropeptide Y (NPY) is a 36-amino acid peptide that is widely distributed in the brain, adrenal medulla, and sympathetic nervous system. Several lines of evidence suggest a possible involvement of the NPY system in the physiological effects of several classes of abused substances including alcohol, phencyclidine, cocaine, and marijuana and in endogenous psychosis. Accordingly, it was hypothesized that the NPY system may also be involved in methamphetamine dependence or psychosis. Methods: The single nucleotide polymorphisms rs16147 of the NPY gene (-485C>T) and rs7687423 of the NPY receptor Y1 (NPY1R) gene were analyzed in 222 patients with methamphetamine dependence and psychosis and 288 age- and gender-matched controls. Results: Genotypic distribution of the NPY1R gene showed a significant association with methamphetamine dependence and psychosis (P = 0.04), whereas the NPY gene had no significant association with them. Conclusion: It is possible that genetic variants of the NPY1R gene affect the NPY-NPY receptor type Y1 signaling system in the brain, which may result in susceptibility to methamphetamine dependence or the development of methamphetamine psychosis, but the present findings need to be confirmed on replication.

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