Association Between Oxidized LDL and Folate During Pregnancy

Mie Shiraishi, Megumi Haruna, Masayo Matsuzaki, Erika Ota, Ryoko Murayama, Etsuko Watanabe, Satoshi Sasaki, Seon Ae Yeo, Sachiyo Murashima

Research output: Contribution to journalArticlepeer-review


High levels of oxidized low-density lipoprotein (ox-LDL) during pregnancy are a risk factor for preeclampsia. Ox-LDL levels might be affected by folate and total homocysteine (tHcy) levels because of their effects on oxygen free radicals. The relationships between ox-LDL and folate and tHcy during pregnancy, however, remain unclear. The present study investigated whether serum folate levels and plasma tHcy levels were associated with plasma ox-LDL levels in pregnant women. A sample of 137 healthy subjects with singleton pregnancies (age 30.3 ± 4.5 years) was recruited from a prenatal clinic in metropolitan Tokyo between June and October 2008. Their levels of plasma ox-LDL, plasma tHcy, and serum folate were measured, and lifestyle variables were obtained using a questionnaire. Dietary intake was assessed by means of a validated self-administered diet history questionnaire. A negative correlation between plasma ox-LDL levels and serum folate levels was found (rs = -.218, p =.011). However, there was no association between plasma ox-LDL levels and plasma tHcy levels (rs =.055, p =.525). The mean of the logarithmic ox-LDL levels was significantly lower among the participants taking folic acid-containing supplements regularly than among those who were not, after adjusting for confounding factors (p =.024). Serum folate levels and folic acid supplementation might be associated with plasma ox-LDL levels, independent of tHcy levels. The association observed between ox-LDL and folate can be used as evidence for dietary instruction by prenatal care providers.

Original languageEnglish
Pages (from-to)213-218
Number of pages6
JournalBiological Research for Nursing
Issue number2
Publication statusPublished - 04-2013

All Science Journal Classification (ASJC) codes

  • Research and Theory


Dive into the research topics of 'Association Between Oxidized LDL and Folate During Pregnancy'. Together they form a unique fingerprint.

Cite this