TY - JOUR
T1 - Association Between Oxidized LDL and Folate During Pregnancy
AU - Shiraishi, Mie
AU - Haruna, Megumi
AU - Matsuzaki, Masayo
AU - Ota, Erika
AU - Murayama, Ryoko
AU - Watanabe, Etsuko
AU - Sasaki, Satoshi
AU - Yeo, Seon Ae
AU - Murashima, Sachiyo
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article from the Kao Research Council for the Study of Healthcare Science 2008 and a Grant-in-Aid for Scientific Research, Exploratory Research 2006-2008 (No. 19659578) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
PY - 2013/4
Y1 - 2013/4
N2 - High levels of oxidized low-density lipoprotein (ox-LDL) during pregnancy are a risk factor for preeclampsia. Ox-LDL levels might be affected by folate and total homocysteine (tHcy) levels because of their effects on oxygen free radicals. The relationships between ox-LDL and folate and tHcy during pregnancy, however, remain unclear. The present study investigated whether serum folate levels and plasma tHcy levels were associated with plasma ox-LDL levels in pregnant women. A sample of 137 healthy subjects with singleton pregnancies (age 30.3 ± 4.5 years) was recruited from a prenatal clinic in metropolitan Tokyo between June and October 2008. Their levels of plasma ox-LDL, plasma tHcy, and serum folate were measured, and lifestyle variables were obtained using a questionnaire. Dietary intake was assessed by means of a validated self-administered diet history questionnaire. A negative correlation between plasma ox-LDL levels and serum folate levels was found (rs = -.218, p =.011). However, there was no association between plasma ox-LDL levels and plasma tHcy levels (rs =.055, p =.525). The mean of the logarithmic ox-LDL levels was significantly lower among the participants taking folic acid-containing supplements regularly than among those who were not, after adjusting for confounding factors (p =.024). Serum folate levels and folic acid supplementation might be associated with plasma ox-LDL levels, independent of tHcy levels. The association observed between ox-LDL and folate can be used as evidence for dietary instruction by prenatal care providers.
AB - High levels of oxidized low-density lipoprotein (ox-LDL) during pregnancy are a risk factor for preeclampsia. Ox-LDL levels might be affected by folate and total homocysteine (tHcy) levels because of their effects on oxygen free radicals. The relationships between ox-LDL and folate and tHcy during pregnancy, however, remain unclear. The present study investigated whether serum folate levels and plasma tHcy levels were associated with plasma ox-LDL levels in pregnant women. A sample of 137 healthy subjects with singleton pregnancies (age 30.3 ± 4.5 years) was recruited from a prenatal clinic in metropolitan Tokyo between June and October 2008. Their levels of plasma ox-LDL, plasma tHcy, and serum folate were measured, and lifestyle variables were obtained using a questionnaire. Dietary intake was assessed by means of a validated self-administered diet history questionnaire. A negative correlation between plasma ox-LDL levels and serum folate levels was found (rs = -.218, p =.011). However, there was no association between plasma ox-LDL levels and plasma tHcy levels (rs =.055, p =.525). The mean of the logarithmic ox-LDL levels was significantly lower among the participants taking folic acid-containing supplements regularly than among those who were not, after adjusting for confounding factors (p =.024). Serum folate levels and folic acid supplementation might be associated with plasma ox-LDL levels, independent of tHcy levels. The association observed between ox-LDL and folate can be used as evidence for dietary instruction by prenatal care providers.
UR - https://www.scopus.com/pages/publications/84873457162
UR - https://www.scopus.com/inward/citedby.url?scp=84873457162&partnerID=8YFLogxK
U2 - 10.1177/1099800411427581
DO - 10.1177/1099800411427581
M3 - Article
AN - SCOPUS:84873457162
SN - 1099-8004
VL - 15
SP - 213
EP - 218
JO - Biological Research for Nursing
JF - Biological Research for Nursing
IS - 2
ER -