Association between parental history of diabetes and the incidence of type 2 diabetes mellitus differs according to the sex of the parent and offspring's body weight: A finding from a Japanese worksite-based cohort study

Chaochen Wang, Hiroshi Yatsuya, Koji Tamakoshi, Hideaki Toyoshima, Keiko Wada, Enei Ri, Esayas Haregot Hilawe, Mayu Uemura, Chifa Chiang, Yan Zhang, Rei Otsuka, Atsuhiko Ota, Yoshihisa Hirakawa, Atsuko Aoyama

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To investigate differences in the association of parental history of diabetes with the risk of type 2 diabetes mellitus (T2DM) in the offspring according to the sex of the parent and the offspring's body weight. Methods: A prospective cohort study of 4446 middle-aged non-diabetic Japanese men and women were followed in Aichi Prefecture, central Japan, from 2002 to 2011. Subjects were categorized by their self-reported parental history of diabetes ("no parental history," "father only," "mother only," and "both"). The association of parental history of diabetes and incidence in the offspring was examined according to overweight status adjusted for age, sex, birth weight, smoking, alcohol consumption, physical activity, total energy intake, body mass index, and number of metabolic syndrome components. Results: During follow-up (median 8.9. years), 277 subjects developed T2DM. Parental history of diabetes was positively associated with T2DM incidence. However, stratified analysis by overweight status revealed that only maternal history was associated with increased T2DM incidence in non-overweight subjects (hazard ratio. =. 2.35, 95% confidence interval: 1.41-3.91). While in overweight subjects, paternal history was significantly associated with higher T2DM incidence (hazard ratio. =. 1.98, 95% confidence interval: 1.19-3.28). Conclusions: Our results suggest that parental history of diabetes mellitus is associated with the incidence of T2DM in offspring differently according to the sex of the affected parent and the offspring's body weight.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalPreventive Medicine
Volume81
DOIs
Publication statusPublished - 01-12-2015

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Workplace
Type 2 Diabetes Mellitus
Cohort Studies
Body Weight
Incidence
Mothers
Confidence Intervals
Energy Intake
Birth Weight
Fathers
Alcohol Drinking
Diabetes Mellitus
Japan
Body Mass Index
Smoking
History
Prospective Studies
Exercise

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Wang, Chaochen ; Yatsuya, Hiroshi ; Tamakoshi, Koji ; Toyoshima, Hideaki ; Wada, Keiko ; Ri, Enei ; Hilawe, Esayas Haregot ; Uemura, Mayu ; Chiang, Chifa ; Zhang, Yan ; Otsuka, Rei ; Ota, Atsuhiko ; Hirakawa, Yoshihisa ; Aoyama, Atsuko. / Association between parental history of diabetes and the incidence of type 2 diabetes mellitus differs according to the sex of the parent and offspring's body weight : A finding from a Japanese worksite-based cohort study. In: Preventive Medicine. 2015 ; Vol. 81. pp. 49-53.
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abstract = "Objective: To investigate differences in the association of parental history of diabetes with the risk of type 2 diabetes mellitus (T2DM) in the offspring according to the sex of the parent and the offspring's body weight. Methods: A prospective cohort study of 4446 middle-aged non-diabetic Japanese men and women were followed in Aichi Prefecture, central Japan, from 2002 to 2011. Subjects were categorized by their self-reported parental history of diabetes ({"}no parental history,{"} {"}father only,{"} {"}mother only,{"} and {"}both{"}). The association of parental history of diabetes and incidence in the offspring was examined according to overweight status adjusted for age, sex, birth weight, smoking, alcohol consumption, physical activity, total energy intake, body mass index, and number of metabolic syndrome components. Results: During follow-up (median 8.9. years), 277 subjects developed T2DM. Parental history of diabetes was positively associated with T2DM incidence. However, stratified analysis by overweight status revealed that only maternal history was associated with increased T2DM incidence in non-overweight subjects (hazard ratio. =. 2.35, 95{\%} confidence interval: 1.41-3.91). While in overweight subjects, paternal history was significantly associated with higher T2DM incidence (hazard ratio. =. 1.98, 95{\%} confidence interval: 1.19-3.28). Conclusions: Our results suggest that parental history of diabetes mellitus is associated with the incidence of T2DM in offspring differently according to the sex of the affected parent and the offspring's body weight.",
author = "Chaochen Wang and Hiroshi Yatsuya and Koji Tamakoshi and Hideaki Toyoshima and Keiko Wada and Enei Ri and Hilawe, {Esayas Haregot} and Mayu Uemura and Chifa Chiang and Yan Zhang and Rei Otsuka and Atsuhiko Ota and Yoshihisa Hirakawa and Atsuko Aoyama",
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Association between parental history of diabetes and the incidence of type 2 diabetes mellitus differs according to the sex of the parent and offspring's body weight : A finding from a Japanese worksite-based cohort study. / Wang, Chaochen; Yatsuya, Hiroshi; Tamakoshi, Koji; Toyoshima, Hideaki; Wada, Keiko; Ri, Enei; Hilawe, Esayas Haregot; Uemura, Mayu; Chiang, Chifa; Zhang, Yan; Otsuka, Rei; Ota, Atsuhiko; Hirakawa, Yoshihisa; Aoyama, Atsuko.

In: Preventive Medicine, Vol. 81, 01.12.2015, p. 49-53.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between parental history of diabetes and the incidence of type 2 diabetes mellitus differs according to the sex of the parent and offspring's body weight

T2 - A finding from a Japanese worksite-based cohort study

AU - Wang, Chaochen

AU - Yatsuya, Hiroshi

AU - Tamakoshi, Koji

AU - Toyoshima, Hideaki

AU - Wada, Keiko

AU - Ri, Enei

AU - Hilawe, Esayas Haregot

AU - Uemura, Mayu

AU - Chiang, Chifa

AU - Zhang, Yan

AU - Otsuka, Rei

AU - Ota, Atsuhiko

AU - Hirakawa, Yoshihisa

AU - Aoyama, Atsuko

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Objective: To investigate differences in the association of parental history of diabetes with the risk of type 2 diabetes mellitus (T2DM) in the offspring according to the sex of the parent and the offspring's body weight. Methods: A prospective cohort study of 4446 middle-aged non-diabetic Japanese men and women were followed in Aichi Prefecture, central Japan, from 2002 to 2011. Subjects were categorized by their self-reported parental history of diabetes ("no parental history," "father only," "mother only," and "both"). The association of parental history of diabetes and incidence in the offspring was examined according to overweight status adjusted for age, sex, birth weight, smoking, alcohol consumption, physical activity, total energy intake, body mass index, and number of metabolic syndrome components. Results: During follow-up (median 8.9. years), 277 subjects developed T2DM. Parental history of diabetes was positively associated with T2DM incidence. However, stratified analysis by overweight status revealed that only maternal history was associated with increased T2DM incidence in non-overweight subjects (hazard ratio. =. 2.35, 95% confidence interval: 1.41-3.91). While in overweight subjects, paternal history was significantly associated with higher T2DM incidence (hazard ratio. =. 1.98, 95% confidence interval: 1.19-3.28). Conclusions: Our results suggest that parental history of diabetes mellitus is associated with the incidence of T2DM in offspring differently according to the sex of the affected parent and the offspring's body weight.

AB - Objective: To investigate differences in the association of parental history of diabetes with the risk of type 2 diabetes mellitus (T2DM) in the offspring according to the sex of the parent and the offspring's body weight. Methods: A prospective cohort study of 4446 middle-aged non-diabetic Japanese men and women were followed in Aichi Prefecture, central Japan, from 2002 to 2011. Subjects were categorized by their self-reported parental history of diabetes ("no parental history," "father only," "mother only," and "both"). The association of parental history of diabetes and incidence in the offspring was examined according to overweight status adjusted for age, sex, birth weight, smoking, alcohol consumption, physical activity, total energy intake, body mass index, and number of metabolic syndrome components. Results: During follow-up (median 8.9. years), 277 subjects developed T2DM. Parental history of diabetes was positively associated with T2DM incidence. However, stratified analysis by overweight status revealed that only maternal history was associated with increased T2DM incidence in non-overweight subjects (hazard ratio. =. 2.35, 95% confidence interval: 1.41-3.91). While in overweight subjects, paternal history was significantly associated with higher T2DM incidence (hazard ratio. =. 1.98, 95% confidence interval: 1.19-3.28). Conclusions: Our results suggest that parental history of diabetes mellitus is associated with the incidence of T2DM in offspring differently according to the sex of the affected parent and the offspring's body weight.

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