Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women

Tomoko Mabuchi, Hiroshi Yatsuya, Koji Tamakoshi, Rei Otsuka, Nobue Nagasawa, Huiming Zhang, Chiyoe Murata, Keiko Wada, Miyuki Ishikawa, Yoko Hori, Takaaki Kondo, Shuji Hashimoto, Hideaki Toyoshima

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans. Methods: Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were analyzed in relation to their WBC count. Serum leptin concentrations and WBC counts were measured by radioimmunoassay and automated particle counter respectively, using samples obtained at the time of the participants' annual health checkups. Results: The geometric mean (±geometric standard deviation) leptin concentrations were 3.25 ± 1.82 ng/mL and 6.25 ± 3.99 ng/mL, and the geometric mean WBC counts, 5770 ± 1269/mm 3 and 5107 ± 1228/mm 3 , in men and women respectively. The WBC count adjusted for age, body mass index (BMI), physical activity, and drinking and smoking habits increased together with the increase in leptin concentration. Multiple linear regression against WBC count by the leptin concentration and those covariates revealed a significant and independent association with serum leptin concentration especially in women (standardized β = 0.31, p < 0.001), and also in men (standardized β = 0.17, p < 0.001). BMI was not significantly associated with WBC counts in the multivariate model adjusting for leptin levels in both sexes. Conclusions: Our results are in line with leptin's hematopoietic or proinflammatory functions. The increased WBC counts often observed in obese people would be mediated by the increased leptin concentration.

Original languageEnglish
Pages (from-to)441-447
Number of pages7
JournalDiabetes/Metabolism Research and Reviews
Volume21
Issue number5
DOIs
Publication statusPublished - 01-09-2005

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Leptin
Leukocyte Count
Serum
Body Mass Index
Drinking
Habits
Radioimmunoassay
Linear Models
Smoking
Exercise

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Mabuchi, Tomoko ; Yatsuya, Hiroshi ; Tamakoshi, Koji ; Otsuka, Rei ; Nagasawa, Nobue ; Zhang, Huiming ; Murata, Chiyoe ; Wada, Keiko ; Ishikawa, Miyuki ; Hori, Yoko ; Kondo, Takaaki ; Hashimoto, Shuji ; Toyoshima, Hideaki. / Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women. In: Diabetes/Metabolism Research and Reviews. 2005 ; Vol. 21, No. 5. pp. 441-447.
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abstract = "Background: Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans. Methods: Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were analyzed in relation to their WBC count. Serum leptin concentrations and WBC counts were measured by radioimmunoassay and automated particle counter respectively, using samples obtained at the time of the participants' annual health checkups. Results: The geometric mean (±geometric standard deviation) leptin concentrations were 3.25 ± 1.82 ng/mL and 6.25 ± 3.99 ng/mL, and the geometric mean WBC counts, 5770 ± 1269/mm 3 and 5107 ± 1228/mm 3 , in men and women respectively. The WBC count adjusted for age, body mass index (BMI), physical activity, and drinking and smoking habits increased together with the increase in leptin concentration. Multiple linear regression against WBC count by the leptin concentration and those covariates revealed a significant and independent association with serum leptin concentration especially in women (standardized β = 0.31, p < 0.001), and also in men (standardized β = 0.17, p < 0.001). BMI was not significantly associated with WBC counts in the multivariate model adjusting for leptin levels in both sexes. Conclusions: Our results are in line with leptin's hematopoietic or proinflammatory functions. The increased WBC counts often observed in obese people would be mediated by the increased leptin concentration.",
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Mabuchi, T, Yatsuya, H, Tamakoshi, K, Otsuka, R, Nagasawa, N, Zhang, H, Murata, C, Wada, K, Ishikawa, M, Hori, Y, Kondo, T, Hashimoto, S & Toyoshima, H 2005, 'Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women', Diabetes/Metabolism Research and Reviews, vol. 21, no. 5, pp. 441-447. https://doi.org/10.1002/dmrr.540

Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women. / Mabuchi, Tomoko; Yatsuya, Hiroshi; Tamakoshi, Koji; Otsuka, Rei; Nagasawa, Nobue; Zhang, Huiming; Murata, Chiyoe; Wada, Keiko; Ishikawa, Miyuki; Hori, Yoko; Kondo, Takaaki; Hashimoto, Shuji; Toyoshima, Hideaki.

In: Diabetes/Metabolism Research and Reviews, Vol. 21, No. 5, 01.09.2005, p. 441-447.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women

AU - Mabuchi, Tomoko

AU - Yatsuya, Hiroshi

AU - Tamakoshi, Koji

AU - Otsuka, Rei

AU - Nagasawa, Nobue

AU - Zhang, Huiming

AU - Murata, Chiyoe

AU - Wada, Keiko

AU - Ishikawa, Miyuki

AU - Hori, Yoko

AU - Kondo, Takaaki

AU - Hashimoto, Shuji

AU - Toyoshima, Hideaki

PY - 2005/9/1

Y1 - 2005/9/1

N2 - Background: Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans. Methods: Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were analyzed in relation to their WBC count. Serum leptin concentrations and WBC counts were measured by radioimmunoassay and automated particle counter respectively, using samples obtained at the time of the participants' annual health checkups. Results: The geometric mean (±geometric standard deviation) leptin concentrations were 3.25 ± 1.82 ng/mL and 6.25 ± 3.99 ng/mL, and the geometric mean WBC counts, 5770 ± 1269/mm 3 and 5107 ± 1228/mm 3 , in men and women respectively. The WBC count adjusted for age, body mass index (BMI), physical activity, and drinking and smoking habits increased together with the increase in leptin concentration. Multiple linear regression against WBC count by the leptin concentration and those covariates revealed a significant and independent association with serum leptin concentration especially in women (standardized β = 0.31, p < 0.001), and also in men (standardized β = 0.17, p < 0.001). BMI was not significantly associated with WBC counts in the multivariate model adjusting for leptin levels in both sexes. Conclusions: Our results are in line with leptin's hematopoietic or proinflammatory functions. The increased WBC counts often observed in obese people would be mediated by the increased leptin concentration.

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