Association between stroke lesions and videofluoroscopic findings in acute stroke patients

Masahiro Nakamori, Naohisa Hosomi, Eiji Imamura, Hayato Matsushima, Yuta Maetani, Mitsuyoshi Yoshida, Mineka Yoshikawa, Chiho Takeda, Toshikazu Nagasaki, Shin Masuda, Jun Kayashita, Kazuhiro Tsuga, Keiji Tanimoto, Shinichi Wakabayashi, Hirofumi Maruyama

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background and purpose: We aimed to assess stroke lesions, which play a key role in determining swallowing dysfunction, and findings of videofluoroscopy (VF), which provides the most accurate instrumental assessment for evaluating swallowing function, in patients with acute stroke. Methods: We enrolled 342 patients with first-time acute stroke (age 70.4 ± 12.6 years, 142 female). Patients with dementia and altered mental status due to severe stroke were excluded. All patients underwent cranial magnetic resonance imaging to identify the location of stroke lesion, VF, and tongue pressure measurement. Results: Aspiration was detected in 45 (13.2%) patients. Multivariate analysis identified parietal lobe lesion and the National Institutes of Health Stroke Scale (NIHSS) score as independent significant factors for aspiration (odds ratio 6.33, 95% confidence interval [CI] 2.25–17.84, p < 0.001; odds ratio 1.12, 95% CI 1.03–1.20, p = 0.004, respectively). Swallowing reflex delay was detected in 58 (17.0%) patients. Multivariate analysis identified habitual drinking, basal ganglia lesion, and the NIHSS score as independent significant factors for swallowing reflex delay (odds ratio 0.51, 95% CI 0.26–0.99, p = 0.047; odds ratio 1.91, 95% CI 1.09–3.67, p = 0.041; odds ratio 1.12, 95% CI 1.05–1.20, p < 0.001, respectively). Additionally, oral cavity and pharyngeal residues were independently associated with tongue pressure. Conclusion: Parietal lobe lesions are associated with aspiration and basal ganglia lesions with swallowing reflex delay.

Original languageEnglish
Pages (from-to)1025-1035
Number of pages11
JournalJournal of Neurology
Volume268
Issue number3
DOIs
Publication statusPublished - 03-2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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