TY - JOUR
T1 - Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity
AU - Hiyoshi, Mineyoshi
AU - Uemura, Hirokazu
AU - Arisawa, Kokichi
AU - Nakamoto, Mariko
AU - Hishida, Asahi
AU - Okada, Rieko
AU - Matsuo, Keitaro
AU - Kita, Yoshikuni
AU - Niimura, Hideshi
AU - Kuriyama, Nagato
AU - Nanri, Hinako
AU - Ohnaka, Keizo
AU - Suzuki, Sadao
AU - Mikami, Haruo
AU - Kubo, Michiaki
AU - Tanaka, Hideo
AU - Hamajima, Nobuyuki
N1 - Funding Information:
This study was supported in part by Grants-in-Aid for Scientific Research on Priority Areas of Cancer (No. 17015018 ) and on Innovative Areas (No. 221S0001 ) from the Japanese Ministry of Education, Culture, Sports, Science and Technology .
PY - 2012/4/1
Y1 - 2012/4/1
N2 - In our previous proteomic study in rat liver damaged by carbon tetrachloride, soluble catechol- O-methyltransferase (COMT) increased as a phosphorylated form and decreased as a dephosphorylated form. This finding raised the possibility that the COMT protein is associated with liver function. Thus, we hypothesized that (1) the COMT gene contributes to liver homeostasis and (2) a COMT polymorphism (rs4680: Val158Met) causing thermolability of enzymatic activity affects liver enzymes (e.g., aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase (γ-GT)) in serum. To investigate (2), we statistically analyzed the association between COMT genotypes and serum ALT activity in a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We conducted a multiple logistic regression analysis for males (n = 838) and females (n = 970). Those participants having missing values or a past history of liver cirrhosis or liver cancer were excluded. ALT values were divided into two; elevated (30. IU/L ≤; males n = 239, females n = 90) and normal (< 30. IU/L; males n = 599, females n = 880). In females, non-adjusted and adjusted odds ratios for ALT values in the rs4680 A/A homozygote (n = 126) compared with the wild-type G/G homozygote (n = 397) were 0.37 (95% CI 0.14-0.96) and 0.34 (95% CI 0.13-0.93), respectively. In males, an analysis of the population aged 35-69 did not reveal any significant difference, but the population aged 45-54 had a significant difference in the non-adjusted and adjusted odds ratio in the G/A heterozygote (n = 89) (0.50 (95% CI 0.27-0.92) and 0.35 (95% CI 0.18-0.71)) and in the A/A homozygote (n = 22) (0.34 (95% CI 0.11-0.99) and 0.22 (95% CI 0.07-0.72)), compared with the G/G homozygote (n = 88). These data suggest that the COMT polymorphism affects serum ALT activity to maintain liver function.
AB - In our previous proteomic study in rat liver damaged by carbon tetrachloride, soluble catechol- O-methyltransferase (COMT) increased as a phosphorylated form and decreased as a dephosphorylated form. This finding raised the possibility that the COMT protein is associated with liver function. Thus, we hypothesized that (1) the COMT gene contributes to liver homeostasis and (2) a COMT polymorphism (rs4680: Val158Met) causing thermolability of enzymatic activity affects liver enzymes (e.g., aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase (γ-GT)) in serum. To investigate (2), we statistically analyzed the association between COMT genotypes and serum ALT activity in a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We conducted a multiple logistic regression analysis for males (n = 838) and females (n = 970). Those participants having missing values or a past history of liver cirrhosis or liver cancer were excluded. ALT values were divided into two; elevated (30. IU/L ≤; males n = 239, females n = 90) and normal (< 30. IU/L; males n = 599, females n = 880). In females, non-adjusted and adjusted odds ratios for ALT values in the rs4680 A/A homozygote (n = 126) compared with the wild-type G/G homozygote (n = 397) were 0.37 (95% CI 0.14-0.96) and 0.34 (95% CI 0.13-0.93), respectively. In males, an analysis of the population aged 35-69 did not reveal any significant difference, but the population aged 45-54 had a significant difference in the non-adjusted and adjusted odds ratio in the G/A heterozygote (n = 89) (0.50 (95% CI 0.27-0.92) and 0.35 (95% CI 0.18-0.71)) and in the A/A homozygote (n = 22) (0.34 (95% CI 0.11-0.99) and 0.22 (95% CI 0.07-0.72)), compared with the G/G homozygote (n = 88). These data suggest that the COMT polymorphism affects serum ALT activity to maintain liver function.
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U2 - 10.1016/j.gene.2012.01.015
DO - 10.1016/j.gene.2012.01.015
M3 - Article
C2 - 22293393
AN - SCOPUS:84863413436
SN - 0378-1119
VL - 496
SP - 97
EP - 102
JO - Gene
JF - Gene
IS - 2
ER -
