Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study

Genki Mizuno; Hiroya Yamada; Eiji Munetsuna; Mirai Yamazaki; Yoshitaka Ando; Ryosuke Fujii; Yoshiki Tsuboi; Atsushi Teshigawara; Itsuki Kageyama; Keisuke Osakabe; Keiko Sugimoto; Hiroaki Ishikawa; Naohiro Ichino; Yoshiji Ohta; Koji Ohashi; Shuji Hashimoto; Koji Suzuki

doi:10.1080/07435800.2022.2121967

Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study

Genki Mizuno
, Hiroya Yamada
, Eiji Munetsuna
, Mirai Yamazaki
, Yoshitaka Ando
, Ryosuke Fujii
, Yoshiki Tsuboi
, Atsushi Teshigawara
, Itsuki Kageyama
, Keisuke Osakabe
, Keiko Sugimoto
, Hiroaki Ishikawa
, Naohiro Ichino
, Yoshiji Ohta
, Koji Ohashi
, Shuji Hashimoto
, Koji Suzuki

visiting faculty

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Introduction: DNA methylation in the CpG sites of intron 1 of HIF3A is associated with body mass index (BMI). This cross-sectional study investigated correlations between DNA methylation of HIF3A and BMI or adiposity parameters in the Japanese population. Method: DNA methylation of HIF3A was quantified via pyrosequencing. Result: DNA methylation of HIF3A differed only in women; DNA methylation level at cg27146050 was associated with visceral adipose tissue thickness and correlated with BMI and percent (%) body fat after excluding smokers. Conclusion: Peripheral blood DNA methylation at the CpG site (cg27146050) of HIF3A correlated with VAT thickness in Japanese women.

Original language	English
Pages (from-to)	130-137
Number of pages	8
Journal	Endocrine Research
Volume	47
Issue number	3-4
DOIs	https://doi.org/10.1080/07435800.2022.2121967
Publication status	Published - 2022

All Science Journal Classification (ASJC) codes

Endocrinology

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10.1080/07435800.2022.2121967

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Mizuno, G., Yamada, H., Munetsuna, E., Yamazaki, M., Ando, Y., Fujii, R., Tsuboi, Y., Teshigawara, A., Kageyama, I., Osakabe, K., Sugimoto, K., Ishikawa, H., Ichino, N., Ohta, Y., Ohashi, K., Hashimoto, S., & Suzuki, K. (2022). Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study. Endocrine Research, 47(3-4), 130-137. https://doi.org/10.1080/07435800.2022.2121967

@article{07ee9d4ec03341328f9354437b383972,

title = "Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study",

abstract = "Introduction: DNA methylation in the CpG sites of intron 1 of HIF3A is associated with body mass index (BMI). This cross-sectional study investigated correlations between DNA methylation of HIF3A and BMI or adiposity parameters in the Japanese population. Method: DNA methylation of HIF3A was quantified via pyrosequencing. Result: DNA methylation of HIF3A differed only in women; DNA methylation level at cg27146050 was associated with visceral adipose tissue thickness and correlated with BMI and percent (\%) body fat after excluding smokers. Conclusion: Peripheral blood DNA methylation at the CpG site (cg27146050) of HIF3A correlated with VAT thickness in Japanese women.",

keywords = "DNA methylation, general population, hypoxia-inducible factor 3A, obesity, visceral adipose tissue",

author = "Genki Mizuno and Hiroya Yamada and Eiji Munetsuna and Mirai Yamazaki and Yoshitaka Ando and Ryosuke Fujii and Yoshiki Tsuboi and Atsushi Teshigawara and Itsuki Kageyama and Keisuke Osakabe and Keiko Sugimoto and Hiroaki Ishikawa and Naohiro Ichino and Yoshiji Ohta and Koji Ohashi and Shuji Hashimoto and Koji Suzuki",

note = "Publisher Copyright: {\textcopyright} 2022 Taylor \& Francis Group, LLC.",

year = "2022",

doi = "10.1080/07435800.2022.2121967",

language = "English",

volume = "47",

pages = "130--137",

journal = "Endocrine Research",

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number = "3-4",

}

Mizuno, G, Yamada, H, Munetsuna, E, Yamazaki, M , Ando, Y , Fujii, R , Tsuboi, Y, Teshigawara, A, Kageyama, I, Osakabe, K , Sugimoto, K , Ishikawa, H , Ichino, N, Ohta, Y, Ohashi, K, Hashimoto, S & Suzuki, K 2022, 'Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study', Endocrine Research, vol. 47, no. 3-4, pp. 130-137. https://doi.org/10.1080/07435800.2022.2121967

TY - JOUR

T1 - Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women

T2 - The Yakumo Study

AU - Mizuno, Genki

AU - Yamada, Hiroya

AU - Munetsuna, Eiji

AU - Yamazaki, Mirai

AU - Ando, Yoshitaka

AU - Fujii, Ryosuke

AU - Tsuboi, Yoshiki

AU - Teshigawara, Atsushi

AU - Kageyama, Itsuki

AU - Osakabe, Keisuke

AU - Sugimoto, Keiko

AU - Ishikawa, Hiroaki

AU - Ichino, Naohiro

AU - Ohta, Yoshiji

AU - Ohashi, Koji

AU - Hashimoto, Shuji

AU - Suzuki, Koji

PY - 2022

Y1 - 2022

N2 - Introduction: DNA methylation in the CpG sites of intron 1 of HIF3A is associated with body mass index (BMI). This cross-sectional study investigated correlations between DNA methylation of HIF3A and BMI or adiposity parameters in the Japanese population. Method: DNA methylation of HIF3A was quantified via pyrosequencing. Result: DNA methylation of HIF3A differed only in women; DNA methylation level at cg27146050 was associated with visceral adipose tissue thickness and correlated with BMI and percent (%) body fat after excluding smokers. Conclusion: Peripheral blood DNA methylation at the CpG site (cg27146050) of HIF3A correlated with VAT thickness in Japanese women.

AB - Introduction: DNA methylation in the CpG sites of intron 1 of HIF3A is associated with body mass index (BMI). This cross-sectional study investigated correlations between DNA methylation of HIF3A and BMI or adiposity parameters in the Japanese population. Method: DNA methylation of HIF3A was quantified via pyrosequencing. Result: DNA methylation of HIF3A differed only in women; DNA methylation level at cg27146050 was associated with visceral adipose tissue thickness and correlated with BMI and percent (%) body fat after excluding smokers. Conclusion: Peripheral blood DNA methylation at the CpG site (cg27146050) of HIF3A correlated with VAT thickness in Japanese women.

KW - DNA methylation

KW - general population

KW - hypoxia-inducible factor 3A

KW - obesity

KW - visceral adipose tissue

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UR - https://www.scopus.com/pages/publications/85138424876#tab=citedBy

U2 - 10.1080/07435800.2022.2121967

DO - 10.1080/07435800.2022.2121967

M3 - Article

C2 - 36104828

AN - SCOPUS:85138424876

SN - 0743-5800

VL - 47

SP - 130

EP - 137

JO - Endocrine Research

JF - Endocrine Research

IS - 3-4

ER -

Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study

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