Association between weight fluctuation and fasting insulin concentration in Japanese men

Hiroshi Yatsuya, K. Tamakoshi, T. Yoshida, Y. Hori, H. Zhang, M. Ishikawa, S. Zhu, T. Kondo, H. Toyoshima

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

OBJECTIVE: To investigate whether long-term weight fluctuation is associated with the fasting serum insulin concentration. DESIGN AND SUBJECTS: Weight histories of 1932 male Japanese workers aged 40-59y were analyzed in relation to their current fasting serum insulin concentration. MEASUREMENTS: Individual weight fluctuation was calculated by root mean square error (RMSF) along the linear regression line of weight measured at five to six different ages. RESULTS: The mean RMSF and fasting insulin concentration were 1.22 kg and 4.5 μU/ml, respectively. The multivariate adjusted insulin level became higher with the increase in weight fluctuation. Subanalysis stratified by current body mass index (BMI) showed that the multivariate adjusted insulin level in individuals in the top quartile of fluctuation was 4.3 μU/ml, against 3.9 μU/ml in those in the bottom quartile (P = 0.018, analysis of covariance (ANCOVA)) in the normal weight subgroup with current BMI below 25 kg/m2. In the overweight subgroup with BMI 25 kg/m2 or above, the level was 6.9 μU/ml in individuals in the top quartile and 6.2 μU/ml in those in the bottom quartile (P = 0.054, ANCOVA). CONCLUSION: The results suggest that weight fluctuation increases the risk of developing hyperinsulinemia. Prospective observations together with measurement of changes in adiposity are needed for confirmation.

Original languageEnglish
Pages (from-to)478-483
Number of pages6
JournalInternational Journal of Obesity
Volume27
Issue number4
DOIs
Publication statusPublished - 01-04-2003
Externally publishedYes

Fingerprint

fasting
Fasting
insulin
Insulin
Weights and Measures
body mass index
Body Mass Index
hyperinsulinemia
Adiposity
Hyperinsulinism
adiposity
Serum
Linear Models

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Yatsuya, Hiroshi ; Tamakoshi, K. ; Yoshida, T. ; Hori, Y. ; Zhang, H. ; Ishikawa, M. ; Zhu, S. ; Kondo, T. ; Toyoshima, H. / Association between weight fluctuation and fasting insulin concentration in Japanese men. In: International Journal of Obesity. 2003 ; Vol. 27, No. 4. pp. 478-483.
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Yatsuya, H, Tamakoshi, K, Yoshida, T, Hori, Y, Zhang, H, Ishikawa, M, Zhu, S, Kondo, T & Toyoshima, H 2003, 'Association between weight fluctuation and fasting insulin concentration in Japanese men', International Journal of Obesity, vol. 27, no. 4, pp. 478-483. https://doi.org/10.1038/sj.ijo.0802221

Association between weight fluctuation and fasting insulin concentration in Japanese men. / Yatsuya, Hiroshi; Tamakoshi, K.; Yoshida, T.; Hori, Y.; Zhang, H.; Ishikawa, M.; Zhu, S.; Kondo, T.; Toyoshima, H.

In: International Journal of Obesity, Vol. 27, No. 4, 01.04.2003, p. 478-483.

Research output: Contribution to journalArticle

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AU - Yatsuya, Hiroshi

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AU - Yoshida, T.

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