Association of a polymorphism in the ornithine decarboxylase gene with whole blood polyamine concentrations in a non-smoking healthy population

Takaaki Kondo, Nobuyuki Hamajima, Kazuko Nishio, Yoshiko Ishida, Ryota Imai, Jun Ueyama, Shoko Torita, Yurie Kasai, Ryoko Yamamoto, Koji Suzuki, Yoshinori Ito

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ornithine decarboxylase (ODC) is the rate-limiting key enzyme in the biosynthesis of polyamines which have been confirmed to possess potent antioxidant and antiglycating properties. The aim of the present study was to examine the relationship of the ODC polymorphism and circulating whole blood polyamine concentrations. The study subjects were non-smoking, healthy men (n = 30) and women (n = 30) aged 55-69 years with equal numbers of AA, GA, and GG genotypes of the ODC gene, who were randomly recruited from 607 health checkup examinees. The whole blood polyamines (spermidine and spermine) were determined by high-performance liquid chromatography and were adjusted for hematocrit. The difference in the adjusted polyamines across the ODC gene was statistically tested using analysis of covariance. Women homozygous for the A-allele showed significantly higher spermidine levels than those with other genotypes. No such association was found among men, and spermine showed no association with the ODC genotype. In conclusion, the ODC polymorphism is significantly associated with whole blood polyamines in women. The ODC gene seems to be expressed more actively among female A-allele homozygotes than women carrying the G-allele.

Original languageEnglish
Pages (from-to)406-412
Number of pages7
JournalJournal of Health Science
Volume53
Issue number4
DOIs
Publication statusPublished - 01-07-2007

Fingerprint

Ornithine Decarboxylase
Polyamines
Polymorphism
Blood
Genes
Population
Spermidine
Spermine
Alleles
Genotype
Association reactions
Biosynthesis
Homozygote
High performance liquid chromatography
Hematocrit
Antioxidants
High Pressure Liquid Chromatography
Health
Enzymes

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Kondo, Takaaki ; Hamajima, Nobuyuki ; Nishio, Kazuko ; Ishida, Yoshiko ; Imai, Ryota ; Ueyama, Jun ; Torita, Shoko ; Kasai, Yurie ; Yamamoto, Ryoko ; Suzuki, Koji ; Ito, Yoshinori. / Association of a polymorphism in the ornithine decarboxylase gene with whole blood polyamine concentrations in a non-smoking healthy population. In: Journal of Health Science. 2007 ; Vol. 53, No. 4. pp. 406-412.
@article{8871bb2c3c864d2591a7d0bc7ae861bb,
title = "Association of a polymorphism in the ornithine decarboxylase gene with whole blood polyamine concentrations in a non-smoking healthy population",
abstract = "Ornithine decarboxylase (ODC) is the rate-limiting key enzyme in the biosynthesis of polyamines which have been confirmed to possess potent antioxidant and antiglycating properties. The aim of the present study was to examine the relationship of the ODC polymorphism and circulating whole blood polyamine concentrations. The study subjects were non-smoking, healthy men (n = 30) and women (n = 30) aged 55-69 years with equal numbers of AA, GA, and GG genotypes of the ODC gene, who were randomly recruited from 607 health checkup examinees. The whole blood polyamines (spermidine and spermine) were determined by high-performance liquid chromatography and were adjusted for hematocrit. The difference in the adjusted polyamines across the ODC gene was statistically tested using analysis of covariance. Women homozygous for the A-allele showed significantly higher spermidine levels than those with other genotypes. No such association was found among men, and spermine showed no association with the ODC genotype. In conclusion, the ODC polymorphism is significantly associated with whole blood polyamines in women. The ODC gene seems to be expressed more actively among female A-allele homozygotes than women carrying the G-allele.",
author = "Takaaki Kondo and Nobuyuki Hamajima and Kazuko Nishio and Yoshiko Ishida and Ryota Imai and Jun Ueyama and Shoko Torita and Yurie Kasai and Ryoko Yamamoto and Koji Suzuki and Yoshinori Ito",
year = "2007",
month = "7",
day = "1",
doi = "10.1248/jhs.53.406",
language = "English",
volume = "53",
pages = "406--412",
journal = "Journal of Health Science",
issn = "1344-9702",
publisher = "Pharmaceutical Society of Japan",
number = "4",

}

Kondo, T, Hamajima, N, Nishio, K, Ishida, Y, Imai, R, Ueyama, J, Torita, S, Kasai, Y, Yamamoto, R, Suzuki, K & Ito, Y 2007, 'Association of a polymorphism in the ornithine decarboxylase gene with whole blood polyamine concentrations in a non-smoking healthy population', Journal of Health Science, vol. 53, no. 4, pp. 406-412. https://doi.org/10.1248/jhs.53.406

Association of a polymorphism in the ornithine decarboxylase gene with whole blood polyamine concentrations in a non-smoking healthy population. / Kondo, Takaaki; Hamajima, Nobuyuki; Nishio, Kazuko; Ishida, Yoshiko; Imai, Ryota; Ueyama, Jun; Torita, Shoko; Kasai, Yurie; Yamamoto, Ryoko; Suzuki, Koji; Ito, Yoshinori.

In: Journal of Health Science, Vol. 53, No. 4, 01.07.2007, p. 406-412.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of a polymorphism in the ornithine decarboxylase gene with whole blood polyamine concentrations in a non-smoking healthy population

AU - Kondo, Takaaki

AU - Hamajima, Nobuyuki

AU - Nishio, Kazuko

AU - Ishida, Yoshiko

AU - Imai, Ryota

AU - Ueyama, Jun

AU - Torita, Shoko

AU - Kasai, Yurie

AU - Yamamoto, Ryoko

AU - Suzuki, Koji

AU - Ito, Yoshinori

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Ornithine decarboxylase (ODC) is the rate-limiting key enzyme in the biosynthesis of polyamines which have been confirmed to possess potent antioxidant and antiglycating properties. The aim of the present study was to examine the relationship of the ODC polymorphism and circulating whole blood polyamine concentrations. The study subjects were non-smoking, healthy men (n = 30) and women (n = 30) aged 55-69 years with equal numbers of AA, GA, and GG genotypes of the ODC gene, who were randomly recruited from 607 health checkup examinees. The whole blood polyamines (spermidine and spermine) were determined by high-performance liquid chromatography and were adjusted for hematocrit. The difference in the adjusted polyamines across the ODC gene was statistically tested using analysis of covariance. Women homozygous for the A-allele showed significantly higher spermidine levels than those with other genotypes. No such association was found among men, and spermine showed no association with the ODC genotype. In conclusion, the ODC polymorphism is significantly associated with whole blood polyamines in women. The ODC gene seems to be expressed more actively among female A-allele homozygotes than women carrying the G-allele.

AB - Ornithine decarboxylase (ODC) is the rate-limiting key enzyme in the biosynthesis of polyamines which have been confirmed to possess potent antioxidant and antiglycating properties. The aim of the present study was to examine the relationship of the ODC polymorphism and circulating whole blood polyamine concentrations. The study subjects were non-smoking, healthy men (n = 30) and women (n = 30) aged 55-69 years with equal numbers of AA, GA, and GG genotypes of the ODC gene, who were randomly recruited from 607 health checkup examinees. The whole blood polyamines (spermidine and spermine) were determined by high-performance liquid chromatography and were adjusted for hematocrit. The difference in the adjusted polyamines across the ODC gene was statistically tested using analysis of covariance. Women homozygous for the A-allele showed significantly higher spermidine levels than those with other genotypes. No such association was found among men, and spermine showed no association with the ODC genotype. In conclusion, the ODC polymorphism is significantly associated with whole blood polyamines in women. The ODC gene seems to be expressed more actively among female A-allele homozygotes than women carrying the G-allele.

UR - http://www.scopus.com/inward/record.url?scp=34547557584&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547557584&partnerID=8YFLogxK

U2 - 10.1248/jhs.53.406

DO - 10.1248/jhs.53.406

M3 - Article

AN - SCOPUS:34547557584

VL - 53

SP - 406

EP - 412

JO - Journal of Health Science

JF - Journal of Health Science

SN - 1344-9702

IS - 4

ER -