Association of abdominal circumference with serum nitric oxide concentration in healthy population

Takaaki Kondo, Jun Ueyama, Ryota Imai, Koji Suzuki, Yoshinori Ito

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: We determined the relationship between abdominal circumference and the concentration of nitric oxide (NO), an endothelial cell product known to play an important role in the regulation of vascular tone and thrombocyte activations. Methods: Subjects were 177 men and 339 women aged 40 or over who were free from a history of diabetes or malignancy. Analysis of covariance was applied to examine the gender-specific and smoking-status-specific associations of abdominal fat volume measured as waist circumference, waist-hip ratio, and waist-to-stature ratio, with serum NO level represented by the concentration of NO metabolites (NOx; nitrate plus nitrite). Results: Although men showed no statistical association between abdominal fat accumulation and NOx concentration, abdominal adiposity seemed to inversely affect the serum NOx concentration of never- and current-smoking women. Conclusion: Our results suggest that a reduction in NO bioactivity occurs with abdominal fat accumulation in women. The underlying biological mechanism might involve adipocytokines secreted from visceral fat, but is yet to be elucidated.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalEnvironmental Health and Preventive Medicine
Volume11
Issue number6
DOIs
Publication statusPublished - 07-12-2006

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Abdominal Fat
Nitric Oxide
Serum
Population
Smoking
Adipokines
Waist-Hip Ratio
Intra-Abdominal Fat
Adiposity
Waist Circumference
Nitrites
Nitrates
Blood Vessels
Blood Platelets
Endothelial Cells
Neoplasms

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Kondo, Takaaki ; Ueyama, Jun ; Imai, Ryota ; Suzuki, Koji ; Ito, Yoshinori. / Association of abdominal circumference with serum nitric oxide concentration in healthy population. In: Environmental Health and Preventive Medicine. 2006 ; Vol. 11, No. 6. pp. 321-325.
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Association of abdominal circumference with serum nitric oxide concentration in healthy population. / Kondo, Takaaki; Ueyama, Jun; Imai, Ryota; Suzuki, Koji; Ito, Yoshinori.

In: Environmental Health and Preventive Medicine, Vol. 11, No. 6, 07.12.2006, p. 321-325.

Research output: Contribution to journalArticle

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AU - Imai, Ryota

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