Association of abdominal obesity with decreased serum levels of carotenoids in a healthy Japanese population

Koji Suzuki, Takashi Inoue, Risa Hioki, Junichi Ochiai, Yasuhiro Kusuhara, Naohiro Ichino, Keisuke Osakabe, Nobuyuki Hamajima, Yoshinori Ito

Research output: Contribution to journalArticle

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Abstract

Background & aims: Few epidemiological studies have investigated the relationship between abdominal adiposity and serum levels of carotenoids. This study investigated the relationship between total and abdominal obesity and serum levels of carotenoids. Methods: Study population consisted of healthy Japanese males (n = 192) and females (n = 398) who attended a health examination screening (age: 49-86 years). Serum carotenoids were measured by high-performance liquid chromatography. Multiple logistic regression analysis was used to provide the multivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) of obesity indices for low levels of serum carotenoids. Results: In females, High waist circumference was associated with low levels of serum canthaxanthin (OR=2.00, 95% CI=1.26-3.19) and beta-carotene (BC) (OR=2.01, 95% CI=1.23-3.28). High waist hip ratio was also associated with low levels of serum alpha- carotene and BC (OR=2.44, 95% CI=1.49-4.03, and OR =1.97, 95% CI=1.20-3.28, respectively). Similar results were obtained when body mass index was added to confounding factors. In males, however, there were no significant associations between obesity indices and serum levels of carotenoids. Conclusions: Our results suggest that abdominal fat accumulation is associated with oxidative stress as determined by low levels of serum carotenoids in females. In males, further study excluding the effect of strong confounding factors, including smoking, is needed.

Original languageEnglish
Pages (from-to)780-789
Number of pages10
JournalClinical Nutrition
Volume25
Issue number5
DOIs
Publication statusPublished - 01-10-2006

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Abdominal Obesity
Carotenoids
Serum
Odds Ratio
Population
Confidence Intervals
beta Carotene
Obesity
Canthaxanthin
Abdominal Fat
Waist-Hip Ratio
Adiposity
Waist Circumference
Epidemiologic Studies
Oxidative Stress
Body Mass Index
Logistic Models
Smoking
High Pressure Liquid Chromatography
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine

Cite this

Suzuki, Koji ; Inoue, Takashi ; Hioki, Risa ; Ochiai, Junichi ; Kusuhara, Yasuhiro ; Ichino, Naohiro ; Osakabe, Keisuke ; Hamajima, Nobuyuki ; Ito, Yoshinori. / Association of abdominal obesity with decreased serum levels of carotenoids in a healthy Japanese population. In: Clinical Nutrition. 2006 ; Vol. 25, No. 5. pp. 780-789.
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Association of abdominal obesity with decreased serum levels of carotenoids in a healthy Japanese population. / Suzuki, Koji; Inoue, Takashi; Hioki, Risa; Ochiai, Junichi; Kusuhara, Yasuhiro; Ichino, Naohiro; Osakabe, Keisuke; Hamajima, Nobuyuki; Ito, Yoshinori.

In: Clinical Nutrition, Vol. 25, No. 5, 01.10.2006, p. 780-789.

Research output: Contribution to journalArticle

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AU - Suzuki, Koji

AU - Inoue, Takashi

AU - Hioki, Risa

AU - Ochiai, Junichi

AU - Kusuhara, Yasuhiro

AU - Ichino, Naohiro

AU - Osakabe, Keisuke

AU - Hamajima, Nobuyuki

AU - Ito, Yoshinori

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N2 - Background & aims: Few epidemiological studies have investigated the relationship between abdominal adiposity and serum levels of carotenoids. This study investigated the relationship between total and abdominal obesity and serum levels of carotenoids. Methods: Study population consisted of healthy Japanese males (n = 192) and females (n = 398) who attended a health examination screening (age: 49-86 years). Serum carotenoids were measured by high-performance liquid chromatography. Multiple logistic regression analysis was used to provide the multivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) of obesity indices for low levels of serum carotenoids. Results: In females, High waist circumference was associated with low levels of serum canthaxanthin (OR=2.00, 95% CI=1.26-3.19) and beta-carotene (BC) (OR=2.01, 95% CI=1.23-3.28). High waist hip ratio was also associated with low levels of serum alpha- carotene and BC (OR=2.44, 95% CI=1.49-4.03, and OR =1.97, 95% CI=1.20-3.28, respectively). Similar results were obtained when body mass index was added to confounding factors. In males, however, there were no significant associations between obesity indices and serum levels of carotenoids. Conclusions: Our results suggest that abdominal fat accumulation is associated with oxidative stress as determined by low levels of serum carotenoids in females. In males, further study excluding the effect of strong confounding factors, including smoking, is needed.

AB - Background & aims: Few epidemiological studies have investigated the relationship between abdominal adiposity and serum levels of carotenoids. This study investigated the relationship between total and abdominal obesity and serum levels of carotenoids. Methods: Study population consisted of healthy Japanese males (n = 192) and females (n = 398) who attended a health examination screening (age: 49-86 years). Serum carotenoids were measured by high-performance liquid chromatography. Multiple logistic regression analysis was used to provide the multivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) of obesity indices for low levels of serum carotenoids. Results: In females, High waist circumference was associated with low levels of serum canthaxanthin (OR=2.00, 95% CI=1.26-3.19) and beta-carotene (BC) (OR=2.01, 95% CI=1.23-3.28). High waist hip ratio was also associated with low levels of serum alpha- carotene and BC (OR=2.44, 95% CI=1.49-4.03, and OR =1.97, 95% CI=1.20-3.28, respectively). Similar results were obtained when body mass index was added to confounding factors. In males, however, there were no significant associations between obesity indices and serum levels of carotenoids. Conclusions: Our results suggest that abdominal fat accumulation is associated with oxidative stress as determined by low levels of serum carotenoids in females. In males, further study excluding the effect of strong confounding factors, including smoking, is needed.

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