Association of AKT1 with schizophrenia confirmed in a Japanese population

Masashi Ikeda, Nakao Iwata, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Toshiya Inada, Norio Ozaki

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Abnormality of the V-akt murine thymoma viral oncogene homologue 1 (AKT1) may be a predisposing factor in schizophrenia. Recent evidence supporting this hypothesis showed decreased AKT1 protein levels in patients with schizophrenia and significant association of AKT1 haplotypes according to the transmission disequilibrium test. We provide the first replication of this evidence using a relatively large case-control sample (507 Japanese schizophrenia and 437 control subjects). We genotyped five single nucleotide polymorphisms (SNPs) from the original study and one additional SNP. We found a positive association with an SNP (SNP5) different from the original study's findings (SNP3) and also significance in the haplotypes constructed from the combination of SNP5. Linkage disequilibrium around SNP5 was complex and may produce this positive association. Our study provides support for the theory that AKT1 is a susceptibility gene for Japanese schizophrenia. Fine linkage disequilibrium mapping is required for a conclusive result.

Original languageEnglish
Pages (from-to)698-700
Number of pages3
JournalBiological Psychiatry
Volume56
Issue number9
DOIs
Publication statusPublished - 01-11-2004

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

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