Association of ANK3 with bipolar disorder confirmed in East Asia

Atsushi Takata, Se Hyun Kim, Norio Ozaki, Nakao Iwata, Hiroshi Kunugi, Toshiya Inada, Hiroshi Ujike, Kazuhiko Nakamura, Norio Mori, Yong Min Ahn, Eun Jeong Joo, Joo Yun Song, Shigenobu Kanba, Takeo Yoshikawa, Yong Sik Kim, Tadafumi Kato

Research output: Contribution to journalArticle

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Abstract

Results of genome-wide association studies (GWASs) for bipolar disorder (BD) have indicated ANK3 as one of the most promising candidates for a susceptibility gene. In this study, we performed genetic association analysis of two single-nucleotide polymorphisms (SNPs) in ANK3 (rs1938526 and rs10994336), whose genome-wide significant associations were reported in a previous meta-analysis of GWASs, using genotyping data of Korean and Japanese case-control samples and a part of data from a GWAS in Han-Chinese from Taiwan. The total number of participants was 2,212 cases (352 from Korea, 860 from Japan, and 1,000 from Taiwan) and 2,244 controls (349 from Korea, 895 from Japan, and 1,000 from Taiwan). We could not detect any significant difference of allele frequency in individual analyses using each of the three populations. However, when we combined the three data sets and performed a meta-analysis, rs1938526 showed nominally significant association (P = 0.048, odds ratio = 1.09). The over-represented allele in BD was same as that reported in Caucasian GWASs. On the other hand, any significant association was not detected in rs10994336. This discrepancy between two SNPs may be explained by the different degree of linkage disequilibrium between Asian and Caucasian. These findings further supported the association between ANK3 and BD, and also suggested the genomic region around rs1938526 as a common risk locus across ethnicities.

Original languageEnglish
Pages (from-to)312-315
Number of pages4
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume156
Issue number3
DOIs
Publication statusPublished - 01-04-2011

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Far East
Genome-Wide Association Study
Bipolar Disorder
Taiwan
Korea
Single Nucleotide Polymorphism
Meta-Analysis
Japan
Linkage Disequilibrium
Gene Frequency
Alleles
Odds Ratio
Genome
Population
Genes

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Takata, Atsushi ; Kim, Se Hyun ; Ozaki, Norio ; Iwata, Nakao ; Kunugi, Hiroshi ; Inada, Toshiya ; Ujike, Hiroshi ; Nakamura, Kazuhiko ; Mori, Norio ; Ahn, Yong Min ; Joo, Eun Jeong ; Song, Joo Yun ; Kanba, Shigenobu ; Yoshikawa, Takeo ; Kim, Yong Sik ; Kato, Tadafumi. / Association of ANK3 with bipolar disorder confirmed in East Asia. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2011 ; Vol. 156, No. 3. pp. 312-315.
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abstract = "Results of genome-wide association studies (GWASs) for bipolar disorder (BD) have indicated ANK3 as one of the most promising candidates for a susceptibility gene. In this study, we performed genetic association analysis of two single-nucleotide polymorphisms (SNPs) in ANK3 (rs1938526 and rs10994336), whose genome-wide significant associations were reported in a previous meta-analysis of GWASs, using genotyping data of Korean and Japanese case-control samples and a part of data from a GWAS in Han-Chinese from Taiwan. The total number of participants was 2,212 cases (352 from Korea, 860 from Japan, and 1,000 from Taiwan) and 2,244 controls (349 from Korea, 895 from Japan, and 1,000 from Taiwan). We could not detect any significant difference of allele frequency in individual analyses using each of the three populations. However, when we combined the three data sets and performed a meta-analysis, rs1938526 showed nominally significant association (P = 0.048, odds ratio = 1.09). The over-represented allele in BD was same as that reported in Caucasian GWASs. On the other hand, any significant association was not detected in rs10994336. This discrepancy between two SNPs may be explained by the different degree of linkage disequilibrium between Asian and Caucasian. These findings further supported the association between ANK3 and BD, and also suggested the genomic region around rs1938526 as a common risk locus across ethnicities.",
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Takata, A, Kim, SH, Ozaki, N, Iwata, N, Kunugi, H, Inada, T, Ujike, H, Nakamura, K, Mori, N, Ahn, YM, Joo, EJ, Song, JY, Kanba, S, Yoshikawa, T, Kim, YS & Kato, T 2011, 'Association of ANK3 with bipolar disorder confirmed in East Asia', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 156, no. 3, pp. 312-315. https://doi.org/10.1002/ajmg.b.31164

Association of ANK3 with bipolar disorder confirmed in East Asia. / Takata, Atsushi; Kim, Se Hyun; Ozaki, Norio; Iwata, Nakao; Kunugi, Hiroshi; Inada, Toshiya; Ujike, Hiroshi; Nakamura, Kazuhiko; Mori, Norio; Ahn, Yong Min; Joo, Eun Jeong; Song, Joo Yun; Kanba, Shigenobu; Yoshikawa, Takeo; Kim, Yong Sik; Kato, Tadafumi.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 156, No. 3, 01.04.2011, p. 312-315.

Research output: Contribution to journalArticle

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T1 - Association of ANK3 with bipolar disorder confirmed in East Asia

AU - Takata, Atsushi

AU - Kim, Se Hyun

AU - Ozaki, Norio

AU - Iwata, Nakao

AU - Kunugi, Hiroshi

AU - Inada, Toshiya

AU - Ujike, Hiroshi

AU - Nakamura, Kazuhiko

AU - Mori, Norio

AU - Ahn, Yong Min

AU - Joo, Eun Jeong

AU - Song, Joo Yun

AU - Kanba, Shigenobu

AU - Yoshikawa, Takeo

AU - Kim, Yong Sik

AU - Kato, Tadafumi

PY - 2011/4/1

Y1 - 2011/4/1

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