Association of body mass index and risk of death from pancreas cancer in Asians

Findings from the Asia Cohort Consortium

Yingsong Lin, Rong Fu, Eric Grant, Yu Chen, Jung Eun Lee, Prakash C. Gupta, Kunnambath Ramadas, Manami Inoue, Shoichiro Tsugane, Yu Tang Gao, Akiko Tamakoshi, Xiao Ou Shu, Kotaro Ozasa, Ichiro Tsuji, Masako Kakizaki, Hideo Tanaka, Chien Jen Chen, Keun Young Yoo, Yoon Ok Ahn, Habibul Ahsan & 22 others Mangesh S. Pednekar, Catherine Sauvaget, Shizuka Sasazuki, Gong Yang, Yong Bing Xiang, Waka Ohishi, Takashi Watanabe, Yoshikazu Nishino, Keitaro Matsuo, San Lin You, Sue K. Park, Dong Hyun Kim, Faruque Parvez, Betsy Rolland, Dale McLerran, Rashmi Sinha, Paolo Boffetta, Wei Zheng, Mark Thornquist, Ziding Feng, Daehee Kang, John D. Potter

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We aimed to examine the association between BMI and the risk of death from pancreas cancer in a pooled analysis of data from the Asia Cohort Consortium. The data for this pooled analysis included 883 529 men and women from 16 cohort studies in Asian countries. Cox proportional-hazards models were used to estimate the hazard ratios and 95% confidence intervals for pancreas cancer mortality in relation to BMI. Seven predefined BMI categories (<18.5, 18.5-19.9, 20.0-22.4, 22.5-24.9, 25.0-27.4, 27.5-29.9, ≥30) were used in the analysis, with BMI of 22.5-24.9 serving as the reference group. The multivariable analyses were adjusted for known risk factors, including age, smoking, and a history of diabetes. We found no statistically significant overall association between each BMI category and the risk of death from pancreas cancer in all Asians, and obesity was unrelated to the risk of mortality in both East Asians and South Asians. Age, smoking, and a history of diabetes did not modify the association between BMI and the risk of death from pancreas cancer. In planned subgroup analyses among East Asians, an increased risk of death from pancreas cancer among those with a BMI less than 18.5 was observed for individuals with a history of diabetes; hazard ratio=2.01 (95% confidence interval: 1.01-4.00) (P for interaction=0.07). The data do not support an association between BMI and the risk of death from pancreas cancer in these Asian populations.

Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalEuropean Journal of Cancer Prevention
Volume22
Issue number3
DOIs
Publication statusPublished - 01-05-2013

Fingerprint

Pancreatic Neoplasms
Body Mass Index
Smoking
Confidence Intervals
Mortality
Proportional Hazards Models
Cohort Studies
Obesity
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Lin, Yingsong ; Fu, Rong ; Grant, Eric ; Chen, Yu ; Lee, Jung Eun ; Gupta, Prakash C. ; Ramadas, Kunnambath ; Inoue, Manami ; Tsugane, Shoichiro ; Gao, Yu Tang ; Tamakoshi, Akiko ; Shu, Xiao Ou ; Ozasa, Kotaro ; Tsuji, Ichiro ; Kakizaki, Masako ; Tanaka, Hideo ; Chen, Chien Jen ; Yoo, Keun Young ; Ahn, Yoon Ok ; Ahsan, Habibul ; Pednekar, Mangesh S. ; Sauvaget, Catherine ; Sasazuki, Shizuka ; Yang, Gong ; Xiang, Yong Bing ; Ohishi, Waka ; Watanabe, Takashi ; Nishino, Yoshikazu ; Matsuo, Keitaro ; You, San Lin ; Park, Sue K. ; Kim, Dong Hyun ; Parvez, Faruque ; Rolland, Betsy ; McLerran, Dale ; Sinha, Rashmi ; Boffetta, Paolo ; Zheng, Wei ; Thornquist, Mark ; Feng, Ziding ; Kang, Daehee ; Potter, John D. / Association of body mass index and risk of death from pancreas cancer in Asians : Findings from the Asia Cohort Consortium. In: European Journal of Cancer Prevention. 2013 ; Vol. 22, No. 3. pp. 244-250.
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abstract = "We aimed to examine the association between BMI and the risk of death from pancreas cancer in a pooled analysis of data from the Asia Cohort Consortium. The data for this pooled analysis included 883 529 men and women from 16 cohort studies in Asian countries. Cox proportional-hazards models were used to estimate the hazard ratios and 95{\%} confidence intervals for pancreas cancer mortality in relation to BMI. Seven predefined BMI categories (<18.5, 18.5-19.9, 20.0-22.4, 22.5-24.9, 25.0-27.4, 27.5-29.9, ≥30) were used in the analysis, with BMI of 22.5-24.9 serving as the reference group. The multivariable analyses were adjusted for known risk factors, including age, smoking, and a history of diabetes. We found no statistically significant overall association between each BMI category and the risk of death from pancreas cancer in all Asians, and obesity was unrelated to the risk of mortality in both East Asians and South Asians. Age, smoking, and a history of diabetes did not modify the association between BMI and the risk of death from pancreas cancer. In planned subgroup analyses among East Asians, an increased risk of death from pancreas cancer among those with a BMI less than 18.5 was observed for individuals with a history of diabetes; hazard ratio=2.01 (95{\%} confidence interval: 1.01-4.00) (P for interaction=0.07). The data do not support an association between BMI and the risk of death from pancreas cancer in these Asian populations.",
author = "Yingsong Lin and Rong Fu and Eric Grant and Yu Chen and Lee, {Jung Eun} and Gupta, {Prakash C.} and Kunnambath Ramadas and Manami Inoue and Shoichiro Tsugane and Gao, {Yu Tang} and Akiko Tamakoshi and Shu, {Xiao Ou} and Kotaro Ozasa and Ichiro Tsuji and Masako Kakizaki and Hideo Tanaka and Chen, {Chien Jen} and Yoo, {Keun Young} and Ahn, {Yoon Ok} and Habibul Ahsan and Pednekar, {Mangesh S.} and Catherine Sauvaget and Shizuka Sasazuki and Gong Yang and Xiang, {Yong Bing} and Waka Ohishi and Takashi Watanabe and Yoshikazu Nishino and Keitaro Matsuo and You, {San Lin} and Park, {Sue K.} and Kim, {Dong Hyun} and Faruque Parvez and Betsy Rolland and Dale McLerran and Rashmi Sinha and Paolo Boffetta and Wei Zheng and Mark Thornquist and Ziding Feng and Daehee Kang and Potter, {John D.}",
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Lin, Y, Fu, R, Grant, E, Chen, Y, Lee, JE, Gupta, PC, Ramadas, K, Inoue, M, Tsugane, S, Gao, YT, Tamakoshi, A, Shu, XO, Ozasa, K, Tsuji, I, Kakizaki, M, Tanaka, H, Chen, CJ, Yoo, KY, Ahn, YO, Ahsan, H, Pednekar, MS, Sauvaget, C, Sasazuki, S, Yang, G, Xiang, YB, Ohishi, W, Watanabe, T, Nishino, Y, Matsuo, K, You, SL, Park, SK, Kim, DH, Parvez, F, Rolland, B, McLerran, D, Sinha, R, Boffetta, P, Zheng, W, Thornquist, M, Feng, Z, Kang, D & Potter, JD 2013, 'Association of body mass index and risk of death from pancreas cancer in Asians: Findings from the Asia Cohort Consortium', European Journal of Cancer Prevention, vol. 22, no. 3, pp. 244-250. https://doi.org/10.1097/CEJ.0b013e3283592cef

Association of body mass index and risk of death from pancreas cancer in Asians : Findings from the Asia Cohort Consortium. / Lin, Yingsong; Fu, Rong; Grant, Eric; Chen, Yu; Lee, Jung Eun; Gupta, Prakash C.; Ramadas, Kunnambath; Inoue, Manami; Tsugane, Shoichiro; Gao, Yu Tang; Tamakoshi, Akiko; Shu, Xiao Ou; Ozasa, Kotaro; Tsuji, Ichiro; Kakizaki, Masako; Tanaka, Hideo; Chen, Chien Jen; Yoo, Keun Young; Ahn, Yoon Ok; Ahsan, Habibul; Pednekar, Mangesh S.; Sauvaget, Catherine; Sasazuki, Shizuka; Yang, Gong; Xiang, Yong Bing; Ohishi, Waka; Watanabe, Takashi; Nishino, Yoshikazu; Matsuo, Keitaro; You, San Lin; Park, Sue K.; Kim, Dong Hyun; Parvez, Faruque; Rolland, Betsy; McLerran, Dale; Sinha, Rashmi; Boffetta, Paolo; Zheng, Wei; Thornquist, Mark; Feng, Ziding; Kang, Daehee; Potter, John D.

In: European Journal of Cancer Prevention, Vol. 22, No. 3, 01.05.2013, p. 244-250.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of body mass index and risk of death from pancreas cancer in Asians

T2 - Findings from the Asia Cohort Consortium

AU - Lin, Yingsong

AU - Fu, Rong

AU - Grant, Eric

AU - Chen, Yu

AU - Lee, Jung Eun

AU - Gupta, Prakash C.

AU - Ramadas, Kunnambath

AU - Inoue, Manami

AU - Tsugane, Shoichiro

AU - Gao, Yu Tang

AU - Tamakoshi, Akiko

AU - Shu, Xiao Ou

AU - Ozasa, Kotaro

AU - Tsuji, Ichiro

AU - Kakizaki, Masako

AU - Tanaka, Hideo

AU - Chen, Chien Jen

AU - Yoo, Keun Young

AU - Ahn, Yoon Ok

AU - Ahsan, Habibul

AU - Pednekar, Mangesh S.

AU - Sauvaget, Catherine

AU - Sasazuki, Shizuka

AU - Yang, Gong

AU - Xiang, Yong Bing

AU - Ohishi, Waka

AU - Watanabe, Takashi

AU - Nishino, Yoshikazu

AU - Matsuo, Keitaro

AU - You, San Lin

AU - Park, Sue K.

AU - Kim, Dong Hyun

AU - Parvez, Faruque

AU - Rolland, Betsy

AU - McLerran, Dale

AU - Sinha, Rashmi

AU - Boffetta, Paolo

AU - Zheng, Wei

AU - Thornquist, Mark

AU - Feng, Ziding

AU - Kang, Daehee

AU - Potter, John D.

PY - 2013/5/1

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